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Objectives: There are several breast cancer (BC) risk factors—many related to body composition, hormonal status, and fertility patterns. However, it is not known if risk factors in healthy women are associated with specific mammographic features at the time of BC diagnosis. Our aim was to assess the potential association between pre-diagnostic body composition and mammographic features in the diag
BackgroundIn 2015, a selective decrease in the glomerular filtration of middle-sized molecules such as cystatin C compared to small molecules such as creatinine was first described and tentatively termed “Shrunken pore syndrome.” Numerous studies have thereafter found an association between this syndrome (defined by a low eGFRcystatin C to eGFRcreatinine ratio) and mortality and morbidity. In 2023
Size-controlled monodisperse droplets are indispensable in food, cosmetics, and healthcare industries. Although emulsion formation from bulk phases is well-explored, a robust in situ method to continuously reform existing emulsions is unavailable. Remarkably, we introduce a continuous flow acousto-microfluidics technique which enables simultaneous trapping-coalescence-splitting of droplets to refo
BACKGROUND: Systemic lupus erythematosus (SLE) patients, with or without neuropsychiatric SLE (NPSLE), exhibit greater neuronal impairment compared to healthy individuals in terms of neuronal damage, magnet resonance imaging (MRI) changes and cognitive dysfunction. Interferon (IFN)-α is a key immunopathogenic driver of SLE, being persistently overexpressed in the majority of patients. This longitu
The leadership literature has been faulted for framing leaders (and followers) as rational and disembodied information processers. This chapter presents a review of studies that go against this tendency by focusing on how materiality, embodiment, and aesthetics are involved in leadership communication. A number of different perspectives are highlighted in relation to the three focal themes, as wel
BACKGROUND: Lung transplantation is hindered by low donor lung utilization rates. Infectious complications are reasons to decline donor grafts due to fear of post-transplant primary graft dysfunction. Mesenchymal stem cells are a promising therapy currently investigated in treating lung injury. Full-term amniotic fluid-derived lung-specific mesenchymal stem cell treatment may regenerate damaged lu
There is a pressing need, particularly in the field of drug discovery, for general methods that will enable direct coupling of tertiary alkyl fragments to (hetero)aryl halides. Herein a uniquely powerful and simple set of conditions for achieving this transformation with unparalleled generality and chemoselectivity is disclosed. This new protocol is placed in context with other recently report
BACKGROUND: Numerous studies report that education and exercise interventions can shift people's willingness to undergo joint replacement surgery for osteoarthritis. We aimed to investigate whether becoming unwilling to undergo surgery following an education and exercise intervention for hip and knee osteoarthritis is associated with lower probability of receiving actual surgery.METHODS AND FINDIN
On-chip light broadcasting can reduce spatial footprint and enhance energy efficiency in photonic neuromorphic systems. We demonstrate on-chip light transmission between InP nanowire photodiodes on silicon, addressing the gap towards complete nanoscale photonic integrated circuits.
Background: Acute kidney injury (AKI) is a serious complication after lung transplantation, but the reported incidence varies in the literature. No data on AKI have been published from the Swedish lung transplantation program. Methods: The aim of our study was to investigate the incidence, perioperative risk factors, and effects of early postoperative acute kidney injury (Kidney Disease Improving
Statistical Jump Models are a class of regime identification models,similar to Hidden Markov Models, with the added advantage of facilitatinglarge-scale integration of exogenous variables that influence thelatent regime-switching process. Recent advancements in SJMs includethe introduction of automatic feature selection techniques, which eliminateirrelevant exogenous information and enhance the mo
Pancreatic ductal adenocarcinoma (PDAC) is a lethal cancer lacking effective drugs and therefore new treatment targets are needed. In this study, we define the role of homeobox protein B6 (HOXB6) and HOXB8 in controlling pancreatic cancer tumorigenesis and immune response. Transcriptomic analysis comparing human embryonic and PDAC tissue identified a large overlap of expression profiles suggesting
Around one-fourth of the global population lacks access to clean fuels and technologies for cooking, most of them living in low- and middle-income countries. Reliance on rudimentary and inefficient biomass cookstoves results in high pollutant concentrations that adversely affect the health of those exposed to indoor air pollution, the environment, and the climate. In this study, we systematically
This thesis aimed to explore the binding pocket of galectin-8N and galectin-3C. Both structure-based drug design and fragment-based drug discovery were utilized in this project, exemplifying the benefits of the different approaches. Structural determination of the proteins in complex with both high affinity ligands, and small fragments was achieved through x-ray crystallography. The structures of
Med utgångspunkt i en rättsdogmatisk metod har denna framställning syftat till att utreda gällande rättsläge beträffande otjänliga försök inom dansk och svensk straffrätt. Mer specifikt är det straffansvarets omfattning vid otjänliga försök som undersökts genom en kritisk komparation mellan svensk och dansk rätt. Som en konsekvens av en vag lagtext i 23 kap. 1 § BrB är otjänliga försök inom svenBy a legal dogmatic method, this thesis has intended to investigate the legislation in force regarding harmless attempted crimes within Danish and Swedish criminal law. More specifically, the scope of criminal liability in the case of harmless attempts has been examined through a critical comparison between Swedish and Danish law. Harmless attempted crimes are because of an indistinct text of la
Domstolarnas uppgift att verka för förlikningar har fått allt större prioritet sedan Rättegångsbalkens införande. När parterna lyckas nå en förlikning i en tvist som är anhängiggjord i domstol kan de välja att begära stadfästelse. Om avtalet reglerar den sak som talan rör ska rätten stadfästa avtalet i en dom. Denna dom får sedan rättskraft och frågan i målet kan därmed inte prövas igen. För att nThe courts’ task of trying to reach a conciliation between parts in a dispute has gained increasing priority since the Swedish Civil procedure law came into force. When parties successfully reach an agreement in a dispute pending in court, they can request ratification. If the agreement addresses the subject matter of the claim, the court will ratify the agreement through a judgment. Through the r
This study aims to explore the experiences women face due to the criminalisation of abortions in the United States. It presents a thematic analysis of the criminalisation of abortion through a feminist framework, examining its profound implications on women's lives. Utilizing secondary data from social media platforms and news outlets, this research will also employ netnography and ethnography
Bakgrund Muskelaktivering och muskelkraft i quadriceps påverkas av bland annat knävinkeln. Sambandet mellan dessa är inte fastställt. Elektromyografi (EMG) används för att undersöka muskelaktivering och ge information om muskelaktivering och muskeltrötthet. Vridmomentet beräknas genom kraft multiplicerat med hävarm. Syfte Syftet med denna studie var att undersöka aktivering av de ytliga quadriceps
