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Ectopic expression of transcription factors has been used to reprogram differentiated somatic cells toward pluripotency or to directly reprogram them to other somatic cell lineages. This concept has been explored in the context of regenerative medicine. Here, we set out to generate dendritic cells (DCs) capable of presenting antigens from mouse and human fibroblasts. By screening combinations of 1
What is the significance of regulations of job contracts and wages when it comes to young people’s access to labour market? This is an issue that has attracted and continues to attract a great deal of interest in both research and politics. Proposals for deregulated employment protection and reduced entry-level pay recur regularly in public debate. In our view it is incomprehensiblehow sectors of
OBJECTIVE: To investigate the relationship between 3 markers of apoptosis, that is, FADD (Fas-associated death domain-containing protein), caspase-3, and caspase-8, and incidence of coronary events (CEs) in a population-based cohort study.APPROACH AND RESULTS: In vitro experiments were performed to assess the response of the apoptotic biomarkers after Fas stimulation of peripheral blood mononuclea
Type 1 (T1D) and type 2 (T2D) diabetes are triggered by a combination of environmental and/or genetic factors. Maf transcription factors regulate pancreatic beta (β)-cell function, and have also been implicated in the regulation of immunomodulatory cytokines like interferon-β (IFNβ1). In this study, we assessed MAFA and MAFB co-expression with pro-inflammatory cytokine signaling genes in RNA-seq d
Background: Right ventricular (RV) systolic function is an important determinant of outcome in patients with pulmonary hypertension (PH). Conventional echocardiographic measures of RV are mainly based on longitudinal contractility. Recently, measurement of RV global longitudinal strain derived from multiple windows (RVGLS) has emerged as an option but has not been well evaluated. The aim of the pr
Hip fractures in elderly carry a high mortality. Our objective was to test the hypothesis that plasma lactate concentration at hospital admission can be used to identify patients with a high risk for poor outcome. Hip fracture patients admitted to a university hospital in Sweden from January 2011 to August 2014 in whom a venous lactate was obtained at admission were included in this prospective ob
BACKGROUND: Numerous studies report that education and exercise interventions can shift people's willingness to undergo joint replacement surgery for osteoarthritis. We aimed to investigate whether becoming unwilling to undergo surgery following an education and exercise intervention for hip and knee osteoarthritis is associated with lower probability of receiving actual surgery.METHODS AND FINDIN
On-chip light broadcasting can reduce spatial footprint and enhance energy efficiency in photonic neuromorphic systems. We demonstrate on-chip light transmission between InP nanowire photodiodes on silicon, addressing the gap towards complete nanoscale photonic integrated circuits.
Background: Acute kidney injury (AKI) is a serious complication after lung transplantation, but the reported incidence varies in the literature. No data on AKI have been published from the Swedish lung transplantation program. Methods: The aim of our study was to investigate the incidence, perioperative risk factors, and effects of early postoperative acute kidney injury (Kidney Disease Improving
Pancreatic ductal adenocarcinoma (PDAC) is a lethal cancer lacking effective drugs and therefore new treatment targets are needed. In this study, we define the role of homeobox protein B6 (HOXB6) and HOXB8 in controlling pancreatic cancer tumorigenesis and immune response. Transcriptomic analysis comparing human embryonic and PDAC tissue identified a large overlap of expression profiles suggesting
Around one-fourth of the global population lacks access to clean fuels and technologies for cooking, most of them living in low- and middle-income countries. Reliance on rudimentary and inefficient biomass cookstoves results in high pollutant concentrations that adversely affect the health of those exposed to indoor air pollution, the environment, and the climate. In this study, we systematically
The human influence on Earth's ecosystems is omnipresent. Artificial light at night (ALAN), anthropogenic noise, and air pollution are inherent features of human activities and infrastructure and pose novel environmental challenges to urban-dwelling wildlife. So far, most of the studies investigating the impacts of exposure to urban pollutants on animals have either investigated the effects of urb
Syftet med denna uppsats är att undersöka hur EU:s reglering av mellanhand-sansvar och de nya processuella skyldigheter som åläggs medieplattformar förhåller sig till det yttrandefrihetsrättsliga skydd som finns i Europakonvent-ionen (EKMR) och EU-stadgan. Uppsatsen innehåller en analys av det grund-läggande skyddet för yttrande- och informationsfriheten som stadgas i artikel 10 EKMR och artikel 1The aim of this study is to examine how the European Union’s regulation of intermediary liability and the new procedural obligations imposed on media platforms relate to the protection of freedom of expression contained in the European Convention on Human Rights (ECHR) and the European Union Charter. The present paper embarks on an analysis of the foundational protection of freedom of expression a
I denna uppsats riktas det in på ett viktigt samt snabbt framväxande område som kan påverka upphovsrättslagen. Den nya kopplingen mellan artificiell intelligens (AI) och upphovsrätten, öppnar upp för nya tolkning av konstnär-liga verk skapade med AI. Det senaste decenniet har det skett en accelererande utveckling när det kommer till AI och denna situation för fram ett flertal både komplexa och svåIn this thesis, attention is directed to an important and rapidly emerging area that can affect copyright law. The new connection between artificial intelli-gence (AI) and copyright law, which opens up for the interpretation of artistic works created with AI. Over the last decade, there has been an accelerating development in AI, and this situation brings forward numerous complex and challenging l
Plankorsningar, där väg och järnväg möts i en punkt, utgör en riskfylld del av transportsystemet. Olyckorna vid plankorsningar har lett till allvarliga konsekvenser i Sverige. Där Sveriges långsiktiga mål (Nollvisionen) syftar på att ingen ska dö eller skadas allvarligt i trafiken, vilket omfattar att öka säkerheten vid plankorsningar för att. Syftet med examensarbete har varit att undersöka säkerLevel crossings, where road and railway intersect at the same point, represent a high-risk part of the transport system. Accidents at level crossings have led to serious consequences in Sweden. Sweden's long-term goal (the Vision Zero) aims for no one to be killed or seriously injured in traffic, which includes increasing safety at level crossings. The purpose of this thesis has been to examin
SÄRSKILT TILLSTÅND att delta i kurser inom forskarutbildning – Ansökan och beslut. SPECIAL PERMISSION to participate in PhD Courses – Application and Decision. 1/1Diarienummer / Reg. No. SÄRSKILT TILLSTÅND att delta i kurser inom forskarutbildning – Ansökan och beslut SPECIAL PERMISSION to participate in PhD Courses – Application and Decision Ansökan / Application Personnummer / Personal identity
https://www.medarbetarwebben.lu.se/sites/medarbetarwebben.lu.se/files/2023-03/Sarskilt-tillstand-sv-eng-2303.pdf - 2026-05-11
ETIKPRÖVNINGSMYNDIGHETEN Främjande av barns delaktighet vid konventionella röntgenundersökningar 1 Information till forskningspersoner, barn 3–12 år Vi vill fråga dig om du vill vara med i en undersökning om hur barn tycker att det är när de ska göra en röntgenundersökning och ta en bild på kroppen. Här får du veta hur det går till om du vill vara med. Vad är det för ett projekt och varför vill ni
https://www.medicin.lu.se/sites/medicin.lu.se/files/2024-03/FPI%20barn%203-12%20%C3%A5r%20rtg%20studie%201.pdf - 2026-05-11
LL_KSME22_161221 Litteraturlista för Hospitality Management: Värdskap och personal, 15 hp (KSME22) Litteraturlistan är fastställd av styrelsen för institutionen för service management och tjänstevetenskap 2016-12-21. Kompletterad med litteratur om arbetsrätt 170102. Litteraturlistan gäller fr o m 2017-01-16. Eksell, Jörgen. (2013). Värdeskapande gästfrihet: hur gästfrihet som värde ramas in, etabl
https://www.ses.lu.se/sites/ses.lu.se/files/ll_ksme22_161221_0.pdf - 2026-05-11
