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Objective: To estimate the 12-year risk of radiographic and/or symptomatic knee osteoarthritis following different MRI-confirmed soft-tissue knee injuries. Design: Prospective cohort study including 814 (70 ​%) of 1129 consecutive patients after acute knee trauma with hemarthrosis in a single hospital. Injuries were classified by sub-acute knee MRI. Follow-up comprised bilateral knee radiography a

Aerosol surface composition plays a critical role in atmospheric chemistry but remains poorly characterized, especially for inorganic systems lacking organic surfactants. While bulk composition is typically measured, key interfacial processes, including heterogeneous reactions, water uptake, and cloud activation, occur at the surface. Here, we present the first depth-resolved, in-flight X-ray phot

Objectives We aimed to describe clinical and diagnostic characteristics of primary care patients with heart failure and physicians’ adherence to guideline-directed medical therapy (GDMT) for treating chronic heart failure. Design Cross-sectional study based on baseline data from the prospective primary care-based study Heart failure in Southern Sweden (HISS). Setting Patients with heart failure we

Antibodies are important for protection against malaria. For optimal protective activity, it is thought that antibodies need to have high affinity. A longitudinal study conducted in Uganda followed newborn infants and their mothers for nine months. The study found that antibody affinity (here measured as dissociation rate constant, kd) against the merozoite antigens AMA1 and MSP2 decreased from bi

The Australian Bogong moth (Agrotis infusa) is a small noctuid moth that undertakes annual, nocturnal migrations of up to 1000 km to escape the summer heat of its breeding grounds. The moths travel to cool alpine caves, where they enter a dormant state (aestivation) before returning to reproduce and die. During migration, their brains integrate magnetic and visual cues to guide their flight direct

Neurodegenerative disorders, such as Alzheimer's and Parkinson's diseases, are associated with the formation of amyloid fibrils. The DNAJB6b (JB6) chaperone greatly inhibits the disease-related self-assembly of amyloid peptides in an ATP-independent manner. The molecular basis of this process is, however, not understood. Here, we studied the low complexity linker between the N- and C-terminal doma

Artificial intelligence (AI) methods are powerful tools for biological image analysis and processing. High-quality annotated images are key to training and developing new algorithms, but access to such data is often hindered by the lack of standards for sharing datasets. We discuss the barriers to sharing annotated image datasets and suggest specific guidelines to improve the reuse of bioimages an

Most scientific instruments currently discard rich streams of commands, data and metadata from which AI systems could learn to conduct experiments with expert-level decision-making and troubleshooting skills. Recording and using this data at scale requires rethinking what data to store, incentivizing large-scale cooperation, and determining how to quantify the reliability of such autonomous system

Organic pollutants in aquatic environments pose a threat to ecosystems and human health, a challenge that requires urgent resolution. This urgent threat highlights the need for the development of efficient technologies for pollutant detection and degradation in environmental protection. This study presents the successful fabrication of a composite nanomaterial consisting of Ag nanoparticle-decorat

The striped p × √3 reconstruction of Au(111) is a textbook example of how electrode surfaces reorganise in response to an applied potential. Using in situ high-energy surface X-ray diffraction, we track the surface reconstruction in 0.1 M HClO4electrolyte while the potential is cycled at both 5 mV s−1and 2 mV s−1between 0.06 V and 0.86 V versus RHE. Reciprocal-space maps, collected every ∼10 s, sh

Photo-induced dynamics of electronic processes are driven by the coupling between electronic and nuclear degrees of freedom. Here, we construct one- and two-dimensional organic-inorganic tin halides to investigate how dimensionality controls exciton-phonon coupling and exciton self-trapping. The results show that a one-dimensional system has strong exciton-phonon coupling leading to excitation-ind

The Aβ42 peptide (APP(672–713)), associated with Alzheimer disease, is highly prone to form amyloid fibrils and has been extensively studied through in vitro experiments. Such experiments represent a basis for understanding the biophysical chemistry of amyloid-related diseases. In this communication, we show that homogeneous primary nucleation in vitro of Aβ42 fibrils is a very rare event, implyin

Intracellular deposits of neurofibrillary tau tangles and extracellular Aβ plaques are closely associated with Alzheimer’s disease. The mapping of thermodynamic parameters, including solubility limits, indicates when a protein forms amyloid fibrils or remains in solution. This reveals the direction of change of the system and may help in understanding drift and steady states in living systems. Her

Action-detected two-dimensional electronic spectroscopy (A-2DES) provides valuable insights into ultrafast dynamics within functional materials and devices by measuring incoherent signals like photocurrent. This work details the implementation and optimization of a pulse-shaper-based A-2DES setup, focusing on methodological strategies crucial for acquiring high-fidelity data. We present a comprehe

In this work, we derive the relationship between the states of strain and stress in pseudomorphic epitaxial layers on a substrate with differing equilibrium lattice parameters under symmetry-conserving conditions for the case of monoclinic crystal symmetry. We compare surface vectors across the template-epitaxial layer interface and impose conditions of a stress-free epitaxial layer. As a result,

Interfacial structures on the nanoscale are crucial for a wide field of applications ranging from biological membranes in life sciences through organic solar cells and industrial coatings in soft matter to hard matter structures. The latter include thin film coatings and materials such as magnetic nanoparticles and topological structures like magnetic skyrmions. Advancing such application rests on

A major challenge hampering the industrial and biological exploitation of lipases is the self-limiting effect of the lipolytic reaction. Defying sustained attention throughout history, the influence of lipase catalysed lipolysis on the internal structure of thin triglyceride films has proved elusive. An in-depth understanding of the lipolysis process at the triglycerides/aqueous interface will ass

Inverted perovskite solar cells (IPSCs) have emerged as promising photovoltaic technologies due to excellent photoelectric properties and solution processing advantages. However, the traditional preparation process based on inert atmosphere annealing of perovskite films faces key challenges, including high energy consumption, strict crystallization control, and the presence of stresses. The study

Background Sweden’s National Strategy for Sexual and Reproductive Health and Rights (SRHR) emphasises equitable access to contraception and abortion services. Despite this, immigrant women in Sweden experience lower contraceptive use and higher rates of unintended pregnancies and abortions compared with native-born women. Midwives, as primary providers of contraceptive counselling and prescribing,