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Severe chronic rhinosinusitis with nasal polyposis (CRSwNP) is a disabling airway disease that significantly impacts patients’ lives through the severity of symptoms, the need for long-term medical treatment and the high risk of recurrence post-surgery. Biological agents targeting type 2 immune responses underlying the pathogenesis of CRSwNP have shown effectiveness in reducing polyp size and eosi

Valid measurement instruments are needed to investigate the impact of parental bonding on child health development. The aim was to develop and validate a self-report questionnaire, the Parent-to-Infant Bonding Scale (PIBS) to measure bonding in both mothers and fathers. Internal consistency and construct validity were analysed using data from Swedish parents from both clinical (N = 182), and commu

We explore the potential of nanocrystals (a term used equivalently to nanoparticles) as building blocks for nanomaterials, and the current advances and open challenges for fundamental science developments and applications. Nanocrystal assemblies are inherently multiscale, and the generation of revolutionary material properties requires a precise understanding of the relationship between structure

We show that weakly entangled states can improve communication over a qubit channel using only separate, interference-free, measurements of individual photons. We introduce a communication task corresponding to the cryptographic primitive known as secret sharing and show that all steerable two-qubit isotropic states provide a quantum advantage in the success rate using only product measurements. F

Quantum thermal machines can generate steady-state entanglement by harvesting spontaneous interactions with local environments. However, using minimal resources and control, the entanglement is typically weak. Here, we study entanglement generation in a two-qubit quantum thermal machine in the presence of a continuous feedback protocol. Each qubit is measured continuously and the outcomes are used

Background: Telomere length (TL) and mitochondrial function expressed as mitochondrial DNA copy number (mtDNAcn) are biomarkers of aging and oxidative stress and inflammation, respectively. Methylmercury (MeHg), a common pollutant in fish, induces oxidative stress. We hypothesized that elevated oxidative stress from exposure to MeHg decreases mtDNAcn and shortens TL. Methods: Study participants ar

BACKGROUND: Beneficial effects from practising a Paleolithic diet as compared to a diabetes diet on weight, waist circumference, satiety, leptin, HbA1c and glucose control in randomised controlled trial participants with type 2 diabetes could be due to lower leptin resistance. Support for this hypothesis comes from an in vitro experiment that showed that digested wheat gluten, which is excluded fr

A recent workshop brought together global leaders in diabetes to assess existing approaches to disease heterogeneity and to identify research gaps, with a goal of achieving precision diabetology for all patients globally.

The tunneling dynamics of a magnetic Dy164 quantum gas in an elongated or pancake skewed double-well trap is investigated with a time-dependent extended Gross-Pitaevskii approach. Upon lifting the energy offset, different tunneling regimes can be identified. In the elongated trap and for sufficiently large offset, the different configurations exhibit collective macroscopic tunneling. For smaller o

Objective: To describe the use of non-steroidal anti-inflammatory drugs (NSAID), opioids, and physiotherapy (PT) among persons with newly diagnosed knee or hip osteoarthritis (OA) with and without NSAID contraindications or precautions. Design: We used population-based register data to identify adults aged ≥35 as of January 1, 2014, residing in Skåne region (Sweden) between 2004 and 2013, without

Simultaneous digital breast tomosynthesis and mechanical imaging (DBTMI), a novel screening approach, combines anatomic DBT with functional analysis of the stress distribution on the compressed breast by mechanical imaging (MI). Preliminary studies suggest potential to reduce false positive findings. DBTMI requires to align DBT and MI images. In this study, we have analyzed robustness to alignment

Background. Whether disease burden in patients with metastatic castration-sensitive prostate cancer (mCSPC) predicts treatment outcomes is unknown. We assessed apalutamide treatment effect in TITAN patients with mCSPC by disease volume, metastasis number and timing of metastasis presentation. Methods. These protocol-defined and post hoc analyses of the phase III randomised TITAN study evaluated cl

OBJECTIVE: This systematic scoping review aimed to map the literature on the use of various nudging strategies to influence prescriber behavior toward reducing opioid prescriptions across diverse healthcare settings.METHODS: A systematic database search was conducted using seven electronic databases. Only articles published in English were included. A total of 2234 articles were identified, 35 of

We show that resonant absorption of smooth laser fields can yield Mollow-like triplet patterns. General conditions for such triplets are derived and illustrated with a super-Gaussian pulse sequence. Gaussian pulses cannot exhibit triplets, super-Gaussian pulses can form triplets depending on the pulse area, and flattop pulses can produce absorption triplets after one Rabi cycle. Our results are co

Nanoparticles have become versatile assets in the medical field, providing notable benefits across diverse medical arenas including controlled drug delivery, imaging, and immunological assays. Among these, non-lamellar lipid nanoparticles, notably cubosomes and hexosomes, showcase remarkable biocompatibility and stability, rendering them as optimal choices for theranostic applications. Particularl

Background: In experimental studies, several polycyclic aromatic hydrocarbons (PAHs) have shown endocrine disrupting properties, but very few epidemiological studies have examined their impact on pubertal development and results have been heterogenous. Objective: To explore if maternal PAH exposure during pregnancy was associated with the offspring's timing of pubertal onset. Methods: We studied 5

Planetary health is being or should be added to medical training curricula in accordance with association consensus. Several articles published in recent years have addressed concern on the implementation, and the challenges that can occur if not addressed properly. This scoping narrative literature review focuses on planetary health as a concept, as well as challenges and suggested solutions to a

Obesity is a major risk factor for metabolic and cardiovascular disease in adults. The Framingham Heart Study was established to follow the development of cardiovascular disease (CVD) over a long period of time and to identify major risk factors for premature death. 1 The study was one of the first to show that obesity is a major risk factor for CVD in adults.

Chiral state transfer along closed loops in the vicinity of an exceptional point is one of the many counterintuitive observations in non-Hermitian physics. The application of this property beyond proof-of-principle in quantum physics, is an open question. In this work, we demonstrate chiral state conversion between singlet and triplet Bell states through fully quantum Liouvillian dynamics. Crucial

A Python package to evaluate Wannier, Wannier–Stark, and EZ (both energy and location Z resolved) levels for quantum cascade lasers is presented. We provide the underlying theory in detail with a focus on the orthonormality and periodicity of the generated states.