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Chronic respiratory diseases are among the leading causes of death worldwide, but only symptomatic therapies are available for terminal illness. This in part reflects a lack of biomimetic in vitro models that can imitate the complex environment and physiology of the lung. Here, a copolymeric membrane consisting of poly(ε-)caprolactone and gelatin with tunable properties, resembling the main charac
The X-ray scanning microscope PtyNAMi at beamline P06 of PETRA III at DESY in Hamburg, Germany, is designed for high-spatial-resolution 3D imaging with high sensitivity. Besides optimizing the coherent ux density on the sample and the precision mechanics of the scanner, special care has been taken to reduce background signals on the detector. The optical path behind the sample is evacuated up unti
Herein, the potential of reformed GaN nanowires (NWs) fabricated by metalorganic chemical vapor deposition (MOCVD) for device-quality low-defect density templates and low-cost alternative to bulk GaN substrates is demonstrated. The effects of epilayer thickness and NW reformation conditions on the crystalline quality and thermal conductivity of the subsequent GaN epilayers are investigated. Smooth
Inhaled antibiotic treatment of cystic fibrosis-related bacterial biofilm infections is challenging because of the pathological environment of the lungs. Here, we present an "environment-adaptive" nanoparticle composed of a solid poly lactic-co-glycolic acid (PLGA) core and a mucus-inert, enzymatically cleavable shell of d-α-tocopheryl polyethylene glycol 1000 succinate (TPGS) for the site-specifi
Aims: Selective participation may hamper the validity of population-based cohort studies. The resulting bias can be alleviated by linking auxiliary register data to both the participants and the non-participants of the study, estimating propensity scores for participation and correcting for participation based on these. However, registry holders may not be allowed to disclose sensitive data on (in
Evacuation planning is an important activity in disaster management to reduce the effects of disasters on urban communities. It is regarded as a multi-objective optimization problem that involves conflicting spatial objectives and constraints in a decision-making process. Such problems are difficult to solve by traditional methods. However, metaheuristics methods have been shown to be proper solut
During the 25 years before the First World War in 1914 two different kinds of peace movements, one bourgeois-liberal and one socialist, were organised to fight militarism and war. The two movements – represented by the International Peace Bureau and the Second International, respectively – grew in size between 1889 and 1914. At the beginning of 1914, IPB organized over 200 peace associations, repr
Potassium and chlorine chemistry at high temperature is of great importance in biomass utilization through thermal conversion. In well-defined hot environments, we performed quantitative measurements of main potassium species, i.e., potassium hydroxide (KOH), potassium chloride (KCl) and K atoms, and the important radical OH. The concentrations of KOH, KCl and OH radicals were measured through a n
Background: The emergence of highly active novel agents has led some to question the role of autologous haematopoietic stem-cell transplantation (HSCT) and subsequent consolidation therapy in newly diagnosed multiple myeloma. We therefore compared autologous HSCT with bortezomib–melphalan–prednisone (VMP) as intensification therapy, and bortezomib–lenalidomide–dexamethasone (VRD) consolidation the
Background: As tumors maintain an inflammatory microenvironment, anti-inflammatory medication can be useful in cancer therapy. We have previously shown an association with improved survival in melanoma for use of the H1-antihistamines desloratadine and loratadine, and here we examine use of H1-antihistamines and breast cancer mortality.Material and methods: We investigated use of the six major H1-
Background The Chronic Kidney Disease Epidemiology Collaboration (CKD-EPI) creatinine equation is routinely used to assess renal function but exhibits varying accuracy depending on patient characteristics and clinical presentation. The overall aim of the present study was to assess if and to what extent glomerular filtration rate (GFR) estimation based on creatinine can be improved.MethodsIn a cro
In this present work, different supports (CeO2/ZrO2) and different Ni contents based catalysts were prepared by incipient wetness impregnation method and tested in the methane steam reforming (MSR) reaction. The prepared catalysts were characterized by X-ray diffraction (XRD) and scanning electron microscope (SEM). The XRD analysis confirmed the prepared Ni/CeO2 samples have a pure crystal structu
Syftet med denna uppsats är att undersöka hur EU:s reglering av mellanhand-sansvar och de nya processuella skyldigheter som åläggs medieplattformar förhåller sig till det yttrandefrihetsrättsliga skydd som finns i Europakonvent-ionen (EKMR) och EU-stadgan. Uppsatsen innehåller en analys av det grund-läggande skyddet för yttrande- och informationsfriheten som stadgas i artikel 10 EKMR och artikel 1The aim of this study is to examine how the European Union’s regulation of intermediary liability and the new procedural obligations imposed on media platforms relate to the protection of freedom of expression contained in the European Convention on Human Rights (ECHR) and the European Union Charter. The present paper embarks on an analysis of the foundational protection of freedom of expression a
Det har visat sig att fysisk aktivitet minskar risken för en rad olika sjukdomar. Studien syftade till att undersöka fysisk aktivitet i olika kontexter och på olika nivåer för att bidra med ny kunskap om eventuella hälsofördelar med fysisk aktivitet. Då det är betydelsefullt för organisationens effektivitet och produktivitet att de anställda mår bra är det också viktigt att organisationen arbetar Physical activity has been shown to reduce the risk of several illnesses. The study aimed to investigate physical activity in different contexts and on different levels to contribute with new knowledge about possible health benefits linked to physical activity. Since the health of the employees is crucial for the organization’s efficiency and productivity it is important that organizations promote
When it comes to absorbing and emitting radiation, molecules show similar properties as atoms do. A signicant dierence though, is that a molecular spectrum consists of notably more absorption lines compared to an atomic spectrum. The additional lines appear due to the fact that molecules can not only exist in electronic, but also in vibrational and rotational energy states. Each gas has uniquely d
The Swedish forest is subject to significant pressure from the forestry industry. As a consequence, biodiversity is negatively affected. Sustainability reporting serves as a means for consumers and stakeholders to gain insight into companies' sustainability ef- forts. Reporting on biodiversity is relatively new compared to climate reporting and poses greater challenges in terms of quantificati
For Those About to Rock... – A study of views of the ensemble repertoire in the aesthetic programme in Swedish high schools In my paper I will present the result of an inquiry made in the aesthetic program in Swedish high schools. The survey covers nine different groups in three different schools in Skåne. As background to my study I have used experiences I have had during my practical workplace t
SammanfattningRapporten är en del av slututvärderingen av Landsbygdsprogram för Sverige 2007-2013 och har tagits fram på uppdrag av Jordbruksverket. Den redovisar resultat och effekter som uppnåddes genom miljö- och klimatåtgärderna inom landsbygdsprogrammet, vilket omfattar samtliga insatser och ersättningar i axel 2, samt miljö- och klimatrelaterade utvärderingsfrågor för en del åtgärder i axel
Streptococcus pneumoniae (pneumococcus) resides asymptomatically in the nasopharynx but can progress from benign colonizer to lethal pulmonary or systemic pathogen. Both viral infection and aging are risk factors for serious pneumococcal infections. Previous work established a murine model that featured the movement of pneumococcus from the nasopharynx to the lung upon nasopharyngeal inoculation w
