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Pancreatic ductal adenocarcinoma (PDAC) is among the deadliest malignancies and potentially curable only with radical surgical resection at early stages. The tumor microenvironment has been shown to be central to the development and progression of PDAC.A better understanding of how early human PDAC metabolically communicates with its environment and differs from healthy pancreas could help improve

BACKGROUND: KRAS mutation can alter the treatment plan after resection of colorectal cancer. Despite its importance, the KRAS status of several patients remains unchecked because of the high cost and limited resources. This study developed a deep neural network (DNN) to predict the KRAS genotype using hematoxylin and eosin (H&E)-stained histopathological images. STUDY DESIGN: Three DNNs were c

To explore if the brain biomarker neuron-specific enolase (NSE) in combination with a biomarker for stress; CT-proAVP (copeptin), oxidation; peroxiredoxin 4 (Prx4), inflammation; procalcitonin (PCT), or with biomarkers from the heart; midregional proatrial natriuretic peptide (MR-proANP), or troponin T (TnT) can improve the prognostic accuracy of long-term outcome after out-of-hospital cardiac arr

The articles included in this thesis centre on what can be called the normative basis of risk analysis. Since risk analyses are decision procedures, they should adhere to norms of rational decision-making, and this they do. Most risk analysis schemes are built on a notion of the decision theoretic maxim that the goal of every decision is to maximize expected utility. However, for some thirty years

Popular Abstract in Swedish En ny typ av vattenlösliga fosfin ligander har utvecklats. Dessa fosfiner har använts som ligander i rhodium katalyserade tvåfasreaktioner.Komplexbildningen mellan de nya liganderna och olika metalcentra har studerats och de nya komplexen har använts i hydroformylerings- och hydreringsreaktioner. Polymerbundna kirala fosfiner har använts i enantioselektiv hydrering.Four new water-soluble phosphines have been prepared by utilising water-soluble polymers as charge carrying units. Coupling of methyl-4-(diphenylphosphino)-benzyl-amine or 4-diphenylphosphino benzaldehyde to poly-acrylic acid and poly-ethylene imine, respectively, afford the ligands PAA-PNH and PEI-PNH. Coupling of (2S,4S)-4-diphenylphosphino-2-di-phenylphosphino-methylpyrrolidine (PPM) or (R,R)-3

An algorithm specific digital signal processor is a powerful alternative to a general purpose signal processor for demanding specifications such as high throughput, low power, small size, etc. These properties are achieved as the processor architecture is tailored to the algorithm as opposed to the general purpose architecture which must suit a wide range of algorithms. The increased performance i

The main goal of SASPENCE is to develop and evaluate an innovative system able to perform the Safe Speed and Safe Distance concept, that means to help the driver in avoiding accident situations related to excessive speed or too small headway. So, the system should co-operate seamlessly with the driver, suggesting the proper velocity for the given condition (road structure, traffic situation, etc.)

This study investigates the public reading of New Testament writings in early Christian communities during the first two centuries C.E. from the perspective of the lectors who prepared and performed the readings. A survey of literary and pictorial sources from the Greek and Roman world indicates that only oratory and drama were delivered from memory, whereas most literary writings were read aloud

In the discipline of archaeology death has always been a common subject. Graves and dead bodies in different states of decay are important sources of information. This dissertation investigates how our relation to death can be mirrored through some of the better-known individuals from prehistory in Scandinavia. Because of the character of the question at issue I start with three chapters in which

The widespread deployment of digital technologies has made the globe an interconnected world. Among other necessities of the digitalized world, cybersecurity is a crucial component. Therefore, education and proper training of the cybersecurity workforce are essential for building a strong national and global community. However, a significant shortage of proficient cybersecurity experts is reported

Most often, the laminar burning velocity (SL) of ammonia was measured in mixtures diluted by nitrogen bearing in mind its potential use as an alternative carbon-free fuel. Replacing the diluent with argon can increase the flame temperature and thus provide additional targets for validating pertinent detailed kinetic models. The SL data for ammonia + oxygen + argon mixtures are scarce; therefore, i

PAM50 gene expression subtypes represent a cornerstone in the molecular classification of breast cancer and are included in risk prediction models to guide therapy. We aimed to illustrate the impact of included genes and biological processes on subtyping while considering a tumor’s underlying clinical subgroup defined by ER, PR, and HER2 status. To do this we used a populationrepresentative and cl

Kan allergiker lita på att chokladen är rätt märkt i butikerna i Ängelholm? För allergiker kan det bokstavligt talat vara livsavgörande att märkningen och informationen på produkter som choklad och kakor är korrekt i våra livsmedelsbutiker. Saknas tydlig information om allergener eller om informationen inte går att förstå p.g.a. att märkningen inte är på svenska kan en allergisk konsument i värstIn December 2014 the requirement increased on pre-packed food labelling when the regulation (EU) No 1169/2011 entered into force. Two important changes were that allergen information must be emphasised in the ingredients list and a minimum font size must be used for the obligatory information on food labels. It´s crucial that grocery stores follow the food legislation, so that consumers and especi

Background This study was conducted at a business unit at the Company, a leading global consumer goods company based in Europe, working in an increasingly hostile environment due to market deregulation and international competition. The business unit was recently separated from previously being integrated in other units and now have high targets to meet. To reach these targets, the rate of innovat

Internetanvändandet har under de senaste decennierna ökat explosionsartat. Det är något som har lett till att allt fler har valt att göra kommers på att olovligen sprida material som är skyddat av upphovsrätten. När olovligt material sprids via internet kan det vara svårt för rättighetsinnehavaren att nå fram till och få den egentlige intrångsgöraren att sluta med intrånget. Många gånger är det de

Objective: Today, stress monitoring on wearable devices is challenged by the tension between high-detection accuracy and battery lifetime driven by multimodal data acquisition and processing. Limited research has addressed the classification cost on multimodal wearable sensors, particularly when the features are cost-dependent. Thus, we design a Cost-Aware Feature Selection (CAFS) methodology that

The infringement of intellectual property rights has devastating effects on trade, the free circulation of goods, employment, development and public health. Rights holders and the companies legitimately exploiting them are the main parties injured by this and in the last few years, infringement has increased by more than 1000%. The Commission has fought against such infringement since the eighties

Popular Abstract in Swedish Till processindustrin räknar man bland annat fabriker som tillverkar papper, plast och livsmedel. I en enda fabrik kan det finnas tusentals PID-regulatorer som har till uppgift att styra storheter som tryck, flöden och temperaturer till önskade värden. PID-regulatorns roll i processindustrin har därför jämförts med den arbetsmyran har i myrstacken. Huruvida en enskild mA large process industry can have somewhere between five hundred and five thousand control loops, and PID controllers are used in 90–97% of the cases. It is well-known that only 20–30% of the controllers in the process industry are tuned satisfactorily, but with the methods available today it is considered too time-consuming to optimize each single controller. This thesis presents tools for analys