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Retinitis pigmentosa (RP), an inherited blinding disease, is caused by a variety of different mutations that affect retinal photoreceptor function and survival. So far there is neither effective treatment nor cure. We have previously shown that poly(ADP-ribose)polymerase (PARP) acts as a common and critical denominator of cell death in photoreceptors, qualifying it as a potential target for future

Phosphorus (P) eutrophication of lakes and streams, coming from drained farmlands, is a serious problem in areas with intensive agriculture. Installation of P sorbing filters at drain outlets may be a solution. Efficient sorbents to be used for such filters must possess high P bonding affinity to retain ortho-phosphate (Pi) at low concentrations. In addition high P sorption capacity, fast bonding

Heavy combined lung weight at autopsy is a non-specific autopsy finding associated with certain causes of death such as intoxication. There is however no clear definition of what constitutes "heavy" lung weight. Different reference values have been suggested but previous studies have been limited by small select populations and only univariate regression has been attempted. The aim of this study w

OBJECTIVE: Huntington disease (HD) is a fatal autosomal dominant, neurodegenerative condition characterized by progressively worsening motor and nonmotor problems including cognitive and neuropsychiatric disturbances, along with sleep abnormalities and weight loss. However, it is not known whether sleep disturbances and metabolic abnormalities underlying the weight loss are present at a premanifes

AimsCan drug abuse (DA) be transmitted psychologically between adult siblings consistent with a social contagion model?MethodsWe followed Swedish sibling pairs born in 1932-1990 until one of them, sibling1 (S1), had a first DA registration. We then examined, using Cox regression, the hazard rate for a first registration for DA in sibling2 (S2) within 3 years of a first DA registration in S1 as a f

BackgroundOlder patients are often vulnerable and highly dependent on healthcare professionals’ assessment in the event of acute illness. In the context of ambulance services, this poses challenges as the assessment is normally conducted with a focus on identifying life-threatening conditions. Such assessment is not fully satisfactory in a patient relationship that also aims to promote and protect

Study region: In the Yangtze River basin of China. Study focus: We applied a recently popular deep learning (DL) algorithm, Transformer (TSF), and two commonly used DL methods, Long-Short-Term Memory (LSTM) and Gated Recurrent Unit (GRU), to evaluate the performance of TSF in predicting runoff in the Yangtze River basin. We also add the main structure of TSF, Self-Attention (SA), to the LSTM and G

Purpose: This study aimed to quantify the relationship between objective and subjective measures of functional ability and determine if measures in the deficient (ACLd) state were correlated to, and capable of predicting a patient's objective and subjective measures in the reconstructed (ACLr) state. Methods: Twenty ACL-injured participants completed hop and side cut movements prior to and 10 mont

The device or the formulation? Which one governs drug dispersibility from the inhaler? To address this question, three budesonide-containing reservoir DPIs: Novopulmon Novolizer®, Giona Easyhaler® and DuoResp Spiromax®, were analyzed using the Next Generation Impactor, NGI. Thereafter, the devices were carefully opened, emptied, and formulations were switched between devices. Finally, three ‘proto

Drought monitoring and prediction have important roles in various aspects of hydrological studies. In the current research, the standardized precipitation index (SPI) was monitored and predicted in Peru between 1990 and 2015. The current study proposed a hybrid model, called ANN-FA, for SPI prediction in various time scales (SPI3, SPI6, SPI18, and SPI24). A state-of-the-art firefly algorithm (FA)

In banana cultivation, a considerable amount of the production is wasted every year because of various constraints present in the post-harvest management chain. Converting green banana pulp and peels into flour could help to reduce losses and enable the food sector to keep the product for an entire year or more. In order to use green banana fruit and peel flour in the food industry as a raw ingred

Characterising the stop/start walking process of individuals in a crowded and congested space is an important consideration in modelling pedestrian movement. However, the reaction of pedestrians to speed changes, especially to the person in front, has not been fully characterised nor quantified for full adoption in computer models. This study, therefore, explored the different phases of the stop/s

Introduction eHealth, defined by WHO as: “the transfer of health resources and healthcare by electronic means” are expected to increase communication between healthcare providers and patients and increase accessibility and patient participation in healthcare. The aim of this research programme is to: 1) develop a sustainable multidisciplinary environment for advancing, evaluating, and implementing

Chronic lung diseases result from alteration and/or destruction of lung tissue, inevitably causing decreased breathing capacity and quality of life for patients. While animal models have paved the way for our understanding of pathobiology and the development of therapeutic strategies for disease management, their translational capacity is limited. There is, therefore, a well-recognised need for in

Objective: The episode patterns of paroxysmal atrial fibrillation (AF) may carry important information on disease progression and complication risk. However, existing studies offer very little insight into to what extent a quantitative characterization of AF patterns can be trusted given the errors in AF detection and various types of shutdown, i.e., poor signal quality and non-we

Data clustering is considered an important component of data mining which aims to split a given dataset into disjoint groups having the same similarities. The developed techniques for clustering have some challenges to cluster entities in complex search space and most of them aim to maximize the sum of inter-cluster distances and minimize the sum of intra-cluster distances. This objective function

Background: Low health literacy is associated with worse pain and poorer self-management. This study (1) examined the level of health literacy and associations with lifestyle habits, health status, chronic pain, and radiographic knee osteoarthritis; and (2) explored experiences illuminating health literacy among individuals with knee pain. Methods: A convergent parallel mixed-methods design was us

Purpose: To investigate the surgical and pharmacological management and outcomes of patients with cataract and concurrent uveitis. Methods: Data from the Swedish National Cataract Register, 2018–2019, were collected and analysed. Uveitic eyes were identified and eyes without uveitis were used as controls. Generalized estimating equations were used to adjust for intra-individual correlation. Result

In Europe, individualist societies, in which people more highly value independence, have fewer people who are lonely. Yet these societies also have more people who live alone, a strong determinant of loneliness. Evidence suggests that some unrecognized societal-level resources or characteristics can explain this.We uncover multiple pathways toward a lower degree of loneliness among European societ