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Control of haemorrhage is vital in all operative settings. As complement to traditional surgical haemostatic techniques, a heterogeneous collection of absorbable substances with haemostatic capacity have been developed; topical haemostatic agents. The widespread variety of the products and the study-populations (clinical or experimental) make interpretation of previously performed studies difficul
We have estimated the hydration free energy for 20 neutral drug-like molecules, as well as for three series of 6-11 inhibitors to avidin, factor Xa, and galectin-3 with four different continuum solvent approaches (the polarised continuum method the Langevin dipole method, the finite-difference solution of the Poisson equation, and the generalised Born method), and several variants of each, giving
Popular Abstract in Swedish Patienter, som på grund av lungsjukdom eller annan skada på lungorna inte kan andas tillfredsställande, kan behandlas med hjälp av en respirator som ventilerar lungorna. Respiratorbehandling kan tyvärr tillfoga redan sjuka eller skadade lungor ytterligare skador. Sådana skador kan uppkomma vid ventilation av lungorna vid alltför stora volymer och höga tryck som leder tiThe elastic pressure-volume (Pel-V) curve of the respiratory system can be used as a guide for improved ventilator management. It may indicate risks of lung damage associated with collapse or overdistension of lung units. The work described in this thesis was aimed at developing methods for the determination and characterisation of the Pel-V curve under static and dynamic conditions and at a bette
This thesis discusses new results on the design and the existence of cryptographically strong Boolean functions used in the design of stream and block ciphers. By interlinking theoretical results and computer search some open problems have been solved, that is, we have shown the existence of previously unknown classes of functions. Furthermore, several general construction methods are exhibited an
Popular Abstract in Swedish Cancer i tjock- och ändtarmen är idag den tredje vanligaste formen av till döden ledande cancer i världen. Den är vanligast i de högindustrialise-rade delarna av världen: Europa, Nord-Amerika och Australien. Prognosen för den enskilde patienten är helt beroende på cancerns utbredning vid diagnostillfället. Cancerns utbredning bedöms idag enligt olika indelningsprincipeAim of the study Today´s methods for the staging of rectal carcinoma: ultrasonography with transrectal probe, CT, MRI or MRI with a rectal coil, all have limitations. The aim was therefore to develop a new, double-contrast MRI method for evaluation of rectal carcinoma. The idea was that a rectally applied contrast medium causing distension and signal void of the rectal lumen and an intravenous inj
The transformation from analogue to digital recording techniques has not only changed the ways of working for the studiotechnician, but affects the musician in the way he thinks about performance and sound, and therefore also his actual performance. The signal processing and the staging of the singing voice in the studio is both influenced by, and influences the estethics of popular song performa
Background Finite mixture models posit the existence of a latent categorical variable and can be used for probabilistic classification. The authors illustrate the use of mixture models for dietary pattern analysis. An advantage of this approach is taking classification uncertainty into account. Methods Participants were a random sample of women from the European Prospective Investigation into Canc
Background: The Lundby Study is a prospective, longitudinal study on a total population consisting of 3563 subjects during 50 years. This study compares first incidence rates of depression and cumulative probabilities for developing a depression over the two time periods 1947-1972 and 1972-1997. Method: The Lundby Study started in 1947. Follow-ups were carried out in 1957 and in 1972. In 1997 the
Hollow fibre (HF) membrane modules were applied in continuous mode for equilibrium sampling through membranes (ESTM) of polar organic pollutants. Phenolic compounds (chlorophenols, cresols and phenol) served as model substances and ESTM was tuned towards the measurement of freely dissolved concentrations (C(free)). HF membrane modules were constructed using thin-walled membrane, 1-m module length
Basic neurotransplantation research evoked clinical trials of restorative brain surgery. Parkinson's disease was the first and primary test bed for this putative new therapeutic method. Various centers performed the grafting surgery and the behavioral evaluations in different ways, and observed a varying degree of symptomatic relief. This led to a plea for double blind placebo-controlled clinical
Subcutaneous continuous infusion of apomorphine has been shown to effectively reduce off-time and dyskinesias in Parkinson's disease (PD). In this multicentre observational cohort study we investigated motor effectivity, tolerability and patient satisfaction with subcutaneous apomorphine infusion therapy over a follow-up period of 2 years. 62 PD patients were included (34 women, 28 men; median age
Objective. Increased fibrinolysis with the risk of bleeding is a consequence of thrombolytic therapy and can also be seen in clinical situations such as acute trauma. Thrombelastography and thrombelastometry are viscoelastic coagulation instruments that can detect higher degrees of fibrinolysis; hyperfibrinolysis. A newer viscoelastic instrument is the ReoRox, which uses free oscillation rheometry
AimTo explore inter-country variation of factors associated with institutionalization of people with dementia. BackgroundThere is an urgent need for evidence on whether factors associated with admission to institutional dementia care are applicable across healthcare systems, as increasing evidence suggests that these factors could be country-specific. DesignA prospective cohort study. MethodPrimar
Age-determinations on a complex array of mafic dykes across the eastern Kaapvaal craton (Olsson et al.. 2010) are complemented herein by field evidence, dyke trend analysis, and petrological characterization of 58 dyke samples. similar to 2.95 Ga SE-trending, a similar to 2.65 Ga E- to SE-radiating, and similar to 1.90 Ga NE-trending swarms can be distinguished. Prominent Archean (similar to 2.95
There are over 100 different types of cancer, and each is classified based on the type of cell that is initially affected. If left untreated, cancer can result in serious health problems and eventually death. Recently the paradigm of cancer chemotherapy has evolved to use a combination approach, which involves the use of multiple drugs each of which targets an individual protein. Inhibition of hea
In breast tomosynthesis1 (BT) a number of 2D projection images are acquired from different angles along a limited arc. The imaged breast volume is reconstructed from the projection images, providing 3D information. The purpose of the study was to investigate and optimize different reconstruction methods for BT in terms of image quality using human observers viewing clinical cases. Sixty-six cases
Here we evaluated the performance of a large set of serum biomarkers for the prediction of rapid progression of chronic kidney disease (CKD) in patients with type 2 diabetes. We used a case-control design nested within a prospective cohort of patients with baseline eGFR 30-60 ml/min per 1.73 m(2). Within a 3.5-year period of Go-DARTS study patients, 154 had over a 40% eGFR decline and 153 controls
Background: In this study data of three national surveys conducted among female sex workers (FSW), prison inmates and people who inject drugs (PWID) were presented and compared in relation to knowledge, attitude, and practises. Methods: The surveys were conducted in 2009 and 2010 and included 2546 PWID, 872 FSW and 5530 prison inmates. Knowledge, attitude and practises towards HIV were measured th
Abstract A fracture of the proximal interphalangeal (PIP) joint at the base of the middle phalanx is rare, but is a challenge to treat. Posttraumatic osteoarthritis is a known complication causing impaired hand function and disability. The aim of the present retrospective study was to evaluate characteristics and outcome of complex PIP joint fractures treated by the pins and rubbers traction syste
