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Antigenic diversity in pathogenic microbes can be a result of at least three different processes: diversifying selection by acquired immunity, host–pathogen coevolution and/or host specialization. Here, we investigate whether host specialization drives diversity at ospC (which encodes an immunodominant surface protein) in the tick-transmitted bacterium Borrelia afzelii. We determined prevalence an
Accident prediction models are often used to predict the number of accidents on segments and at intersections in the road network. Most often the models are developed for a total number of crashes for the facility, or crashes by severity. However, the frequency and severity of crashes of different types can be expected to vary with regards to the underlying phenomena that cause them to occur. To b
This thesis demonstrates the usefulness of sedimentary pigments as biomarkers of environmental change in estuarine systems and as biomarkers in lakes in relation to climate change. These are two fields where sediment pigment records as measured by high-performance liquid chromatography (HPLC) are emerging areas of study. A detailed study was undertaken to examine the effects of different storage o
Accident prediction models are often used to predict the number of accidents on segments and at intersections in the road network. Most often the models are developed for a total number of crashes for the facility, or crashes by severity. However, the frequency and severity of crashes of different types can be expected to vary with regards to the underlying phenomena that cause them to occur. To b
Natural products have until recently provided the only remedy for treatment of diseases. The development of modern chemistry in the last centuries has opened the door for tapping into the chemical diversity found in nature. Synthetic natural products, together with analogues, are an important piece in the puzzle towards curing many ailments. In this thesis, synthetic endeavors towards different bi
The interaction of blood coagulation factor X and its Gla-containing fragments with negatively charged phospholipid membranes composed of 25 mol% phosphatidylserine (PtdSer) and 75 mol% phosphatidylcholine (PtdCho) was studied by surface plasmon resonance. The binding to 100 mol% PtdCho membranes was negligible. The calcium dependence in the membrane binding was evaluated for intact bovine factor
Stability is a fundamental property affecting function, activity, and regulation of biomolecules. Stability changes are often found for mutated proteins involved in diseases. Stability predictors computationally predict protein-stability changes caused by mutations. We performed a systematic analysis of 11 online stability predictors' performances. These predictors are CUPSAT, Dmutant, FoldX, I-Mu
Den svenska jurisdiktionen begränsas av ett krav på dubbel straffbarhet. Detta generella krav infördes år 1972 och hade samband med 1970 års Europeiska brottmålskonvention. I brottsbalken(BrB) 2 kap 2 § 2 stycket står det explicit att en gärnings som begåtts utomlands inte kan dömas enligt svensk rätt om gärningen är fri från ansvar enligt lagen på gärningsorten eller om den begåtts inom ett områdThe Swedish jurisdiction is limited by a requirement of double criminality. This general requirement was introduced in 1972 and was associated with the 1970 European Criminal Convention. The Swedish Criminal Code, chapter 2 2§ second paragraph, it states explicitly that a criminal action committed abroad can not be convicted under Swedish law if the act is free from liability under the law on the
Cykling är en viktig del av ett hållbart transportsystem. Det bidrar bl.a. till en bättre miljö och förbättrad folkhälsa. Syftet med arbetet är att undersöka vilka faktorer som kännetecknar en bra cykelstad, ur en infrastruktursynpunkt och vilka faktorer som kan leda till ökad cykling. I arbetet intervjuas representanter för kommunerna Lund, Malmö och Helsingborg om vilka infrastrukturella åtgärdeCycling is an important part of a sustainable transport system. It contributes among other things to a better environment and improved public health. The aim of this thesis is to investigate which factors characterize a good cycling city, from an infrastructural point of view, and which factors may lead to increased cycling. In the thesis, representatives of the municipalities of Lund, Malmö and H
AbstractThis research aims to investigate and compare how computers work on five different workstation setups of multiple or large screens and viewing distances (27-inch and 49-inch at 70 or 90 cm viewing distance) affect muscular load in neck/shoulders, working postures, and perceived exertions of non-presbyopic participants. The electrical activity in the trapezius shoulder and trapezius neck muThis research aims to investigate and compare how computers work on five different workstation setups of multiple or large screens and viewing distances (27-inch and 49-inch at 70 or 90 cm viewing distance) affect muscular load in neck/shoulders, working postures, and perceived exertions of non-presbyopic participants. The electrical activity in the trapezius shoulder and trapezius neck muscles, a
Diabetes är ett samlingsnamn för sjukdomar där kroppen inte längre kan reglera blodsockret på ett normalt sätt. Sjukdomen ökar snabbt globalt och i Sverige lever i dag hundratusentals människor med någon form av diabetes. Typ 1-diabetes är en autoimmun sjukdom som ofta debuterar i barndomen, medan typ 2-diabetes utvecklas genom ett samspel mellan ärftlighet, ogynnsam fostermiljö, och livsstilsfakt
https://www.medicin.lu.se/bidratillforskning/stod-var-forskning/diabetes - 2026-07-10
Redan som doktorand visste Maria Swanberg en hel del om neurodegenerativa sjukdomar. Men när hennes pappa insjuknade i Parkinsons sjukdom ställdes hon inför nya frågeställningar, bortom forskarrollen. Maria Swanberg, docent numera, fokuserar i sin forskning på olika riskfaktorer bakom Parkinsons sjukdom. Både genetiska faktorer, miljö och livsstil påverkar sjukdomsrisken. – Jag är särskilt intress
BackgroundDespite the fact that eldercare services are organizationally part of social work in Sweden, the social work practice is disappearing and older people are expected to take the responsibility for their own well-being. In this context, they have to create their own sense of meaningfulness in their everyday life, despite being subject to social care services.Methods As part of a research prBackgroundDespite the fact that eldercare services are organizationally part of social work in Sweden, the social work practice is disappearing and older people are expected to take the responsibility for their own well-being. In this context, they have to create their own sense of meaningfulness in their everyday life, despite being subject to social care services.Methods As part of a research pr
Purpose Complex organizations increasingly rely on middle managers as strategic linking-pins between the top and bottom levels of the organization. Using social identity theory and commitment theory as the foundation, this study evaluates a management and leadership development program (MLDP) intended to engage middle managers as strategy creators and implementers. We also evaluate the cascading ePurpose Complex organizations increasingly rely on middle managers as strategic linking-pins between the top and bottom levels of the organization. Using social identity theory and commitment theory as the foundation, this study evaluates a management and leadership development program (MLDP) intended to engage middle managers as strategy creators and implementers. We also evaluate the cascading e
Photomultiplier tube (PMT) nonlinearities relevant for single shot high-speed lifetime phosphor thermometry were investigated by simulating decay curves with a light emitting diode (LED) at repetition rates between 1 Hz and 10 kHz. The PMT gain, LED decay time, and background radiant flux were also varied to investigate their impact on the measured decay time error. Errors in the measured decay tiPhotomultiplier tube (PMT) nonlinearities relevant for single shot high-speed lifetime phosphor thermometry were investigated by simulating decay curves with a light emitting diode (LED) at repetition rates between 1 Hz and 10 kHz. The PMT gain, LED decay time, and background radiant flux were also varied to investigate their impact on the measured decay time error. Errors in the measured decay ti
Sofia läste valbara kurser vid Institutionen för tjänstevetenskap eftersom det dels passade hennes liv och dels för att det stärkte hennes profil för ett arbete inom HR. Vad tyckte du om den valfria terminen?Jag tycker det är skönt att man får välja, även om man väljer att inte åka på utbyte eller praktisera. Du kan gå efter ditt intresse mer och välja inriktning. Det är bra att det också finns mö
Examensarbetet behandlar upphörande av tvångsvård för barn. Lag (1990:52) med särskilda bestämmelser om vård av unga är en skyddslagstiftning som garanterar att utsatta barn ska få sina behov av vård tillgodosedda. Enligt 1 § LVU ska alla beslut som rör barn vara avgörande till vad som är det bästa för det individuella barnet. Samhället har befogenhet att bereda barnet tvångsvård om barnet lever i
