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Popular Abstract in Swedish Denna avhandling beskriver den centrala metabolismen och produktionen av exopolysackarider (EPS) hos två olika mjölksyrabakterier: Lactobacillus reuteri och Pediococcus parvulus. Mjölksyrabakterier används inom livsmedelsindustrin som startkulturer i olika mjölkbaserade produkter. Generellt utnyttjas en specifik metabol väg för nerbrytningen av sockerkällan till mjölksyThis thesis deals with the central carbohydrate metabolism and exopolysaccharide (EPS) formation in two different lactic acid bacteria (LAB): Lactobacillus reuteri and Pediococcus parvulus. LAB are traditionally used as starter cultures in the food industry. In general, LAB harbours one glycolytic pathway converting carbohydrates into lactic acid. However, L. reuteri ATCC 55730 was proven to use t

Popular Abstract in Swedish Det är sedan länge känt att för samma bildkvalitet kan patientstråldosen variera kraftigt mellan två olika sjukhus för en och samma röntgenundersökning. Det finns ett stort utrymme för sänkning av patientstråldosen utan att undersökningens kvalitet påverkas. Vid optimering inom röntgendiagnostik balanseras patientstråldos mot bildkvalitet. Optimeringen kräver att man haOptimisation in diagnostic radiology requires accurate methods for determination of patient absorbed dose and clinical image quality. Simple methods for evaluation of clinical image quality are at present scarce and this project aims at developing such methods. Two methods are used and further developed; fulfilment of image criteria (IC) and visual grading analysis (VGA). Clinical image quality de

From an engineering point of view, uncertainty is present in all areas of design (products, processes and organizations). Computer-based design analysis, here confined to quantitative computer-based structural design analysis within mechanical engineering, serves as an important source of information in decisions taken during the design activity; importantly, it aims at giving confidence in critic

It is known that human errors are the cause of most structural failures. Extreme loads or material deficiencies are normally of secondary importance. This Project has studied the human factor in the design phase; how subjective decisions, individual knowledge and the use of advance tools and codes affect structural safety and structural design. 17 Swedish structural engineers from the house-buildi

Models of moisture flow processes in wood are normally based on a Fickian approach. In many instances, there are considerable discrepancies between modelling and experimental results. It is shown in this thesis that a major cause for these discrepancies is a so-called retarded sorption which is not accounted for in conventional theories. This retarded sorption occurs in the wood cell wall. A spec

Popular Abstract in Swedish Begreppet systemförvaltning började användas i början på 1970-talet. Ämnet har betydelse ur flera perspektiv. Systemförvaltningskostnaderna är som regel betydligt större än systemutvecklingskostnaderna, vilket kan veri¬fieras med flera undersökningar gjorda i olika länder och under en tidsperiod omfattande ett par decennier. Det vetenskapliga intresset för systemförvaltThe term Software Maintenance was coined in the early 1970s. The subject has significance from several points of view. The costs associated with software maintenance are as a rule considerably higher than what the system cost to develop, which is borne out by many studies conducted in different countries over a period of twenty years. Scientific interest in software maintenance, on the other hand,

Aim A key component of library management is meeting the needs of our users. This requires continuous analysis of user experience followed by library development. The aim of this study was to better understand the use and effect of general user surveys (GUS) and other methods of gathering user input for quality assessment and improvement of library activities. Methods Data collection was done via

BACKGROUND: Climate change is set to exacerbate occupational heat strain, the combined effect of environmental and internal heat stress on the body, threatening human health and wellbeing. Therefore, identifying effective, affordable, feasible and sustainable solutions to mitigate the negative effects on worker health and productivity, is an increasingly urgent need. OBJECTIVES: To systematically

Follow-on pharmaceutical innovation occurring after the initial discovery of a drug active ingredient plays an important, but at times underappreciated, role in providing innovative solutions to compelling medical needs. Examples of follow-on innovation include new forms of a drug with improved safety-efficacy profiles, new formulations and dosages providing improved patient outcomes, and new meth

Background: Genome-wide association studies (GWAS) have proven successful in predicting genetic risk of disease using single-locus models; however, identifying single nucleotide polymorphism (SNP) interactions at the genome-wide scale is limited due to computational and statistical challenges. We addressed the computational burden encountered when detecting SNP interactions for survival analysis,

Objective: To estimate the diagnostic performance of sonographic cervical length for the prediction of preterm birth (PTB). Design: Prospective observational multicentre study. Setting: Seven Swedish ultrasound centres. Sample: A cohort of 11 456 asymptomatic women with a singleton pregnancy. Methods: Cervical length was measured with transvaginal ultrasound at 18–20 weeks of gestation (C×1) and a

Background: Health professions education programs are tasked with designing curricula to effectively andefficiently equip their graduates with the required competences and life-long learning skills needed fortoday’s fast-paced, knowledge intensive society. Continuous monitoring and improving of educationalquality is essential to attain these goals. Quality assurance is multi-faceted and requires t

INTRODUCTION: The Alzheimer's Association Global Biomarker Standardization Consortium conducted a blinded case–control study to learn which phosphorylated tau (p-tau) assays provide the largest fold-changes in Alzheimer's disease (AD) versus non-AD and show commutability in measuring patient samples and candidate certified reference materials (CRMs). METHODS: Thirty-three different p-tau assays me

Tool-based code review has been an established software engineering practice for at least a decade. However, while software development environments have improved significantly during this time with advanced features for code comprehension, refactoring, and AI support, code review tools have remained more static and are still centered around a two-way textual diff view with features similar to whe