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Evacuation planning is an important activity in disaster management to reduce the effects of disasters on urban communities. It is regarded as a multi-objective optimization problem that involves conflicting spatial objectives and constraints in a decision-making process. Such problems are difficult to solve by traditional methods. However, metaheuristics methods have been shown to be proper solut

Abnormal patterns of proliferation characterize the behavior of many tumors. Proliferating cell nuclear antigen (PCNA) and Ki‐67 are two cell cycle antigens which are expressed in proliferative states. Our study examines the prognostic value of these cell‐cycle antigens in soft tissue sarcoma (STS). Paraffin‐embedded primary tumor tissues from 185 patients (1980–92) were stained with the anti‐PCNA

Although intimate partner violence is far from a new problem in society, it has lately gained increased attention both by governments and by the research community. In 2007, the Swedish government issued an action plan for “combating men’s violence against women, violence and oppression in the name of honour and violence in same-sex relationships” (2007/08:39), which included a call for increased

Follicular lymphoma (FL) is a heterogeneous disease with varying prognosis owing to differences in clinical, laboratory, and disease parameters. Although generally considered incurable, prognosis for early- and advanced-stage disease has improved because of therapeutic advances, several of which have resulted from elucidation of the biologic and molecular basis of the disease. The choice of treatm

Objective: The aim of this study is to assess the impact of age at onset on the prognostic value of Alzheimer’s biomarkers in a large sample of patients with mild cognitive impairment (MCI). Methods: We measured Aβ42, t-tau, hippocampal volume on magnetic resonance imaging (MRI) and cortical metabolism on fluorodeoxyglucose–positron emission tomography (FDG-PET) in 188 MCI patients followed for at

In order to meet the requirements in the stringent emission regulations, more and more research work has been focused on homogeneous charge compression ignition (HCCI) and partially premixed combustion (PPC) or partially premixed compression ignition (PCCI) as they have the potential to produce low NOx and soot emissions without adverse effects on engine efficiency. The mixture formation and charg

Pressure on consumer goods manufacturers to develop new products with significantly less environmental impact is growing, through increased consumer awareness of environmental issues and governments setting ambitious emissions reductions targets. A strategic response to this pressure is to prepare a portfolio of innovative product ideas to meet a range of future emissions reductions targets. Howev

AIMS : The non-invasive assessment of left ventricular (LV) diastolic function and filling pressure in hypertrophic cardiomyopathy (HCM) is still an open issue. Pulmonary blood volume index (PBVI) by cardiovascular magnetic resonance (CMR) has been proposed as a quantitative biomarker of haemodynamic congestion. We aimed to assess the diagnostic accuracy of PBVI for left atrial pressure (LAP) esti

Precipitation is often the most important input data in hydrological models when simulating streamflow. The Soil and Water Assessment Tool (SWAT), a widely used hydrological model, only makes use of data from one precipitation gauge station that is nearest to the centroid of each subbasin, which is eventually corrected using the elevation band method. This leads in general to inaccurate representa

Importance: Associations between putative risk factors and psychiatric and substance use disorders are widespread in the literature. Basing prevention efforts on such findings is hazardous. Applying causal inference methods, while challenging, is central to developing realistic and potentially actionable etiologic models for psychopathology. Observations: Causal methods can be divided into randomi

In recent years, the flash flood occurs frequently and intensively. It has become a world-wide focus in the field of disaster prevention and mitigation. The flash flood critical rainfall determination method, flash floods forecasting model and experience forecasting method are the most commonly used methods. This study focused on the application of hydrological models for flash floods simulation.T

Background: Softwood is a promising feedstock for lignocellulosic biorefineries, but as it contains galactoglucomannan efficient mannan-degrading enzymes are required to unlock its full potential. Results: Boosting of the saccharification of pretreated softwood (Canadian lodgepole pine) was investigated for 10 fungal endo-β(1→4)-mannanases (endomannanases) from GH5 and GH26, including 6 novel GH26

Purpose:To assess the intraocular pressure (IOP)-reducing effect of latanoprost in treatment-naïve patients with newly detected open-angle glaucoma with no restriction of the level of untreated IOP.Methods:Eighty-six patients (105 eyes) with a diagnosis of open-angle glaucoma received IOP-lowering therapy with latanoprost. The IOP reduction 1 and 3 months after initiation of treatment was recorded

Background: The changing health care environment promotes the adoption of new information technologies to connect patients and health care providers. However, individuals greatly vary in their ability to use new digital systems, and in their feelings regarding integrity and validation. Caregivers in southern Sweden plan to implement a new digital primary health care (DPHC) service, and patients’ e

In beer, the main amphiphilic components are protein and iso-humulone. Two major populations of protein are identified as lipid transfer protein (LTP) (9.7 kDa) and protein Z (43 kDa). In this paper, protein and iso-humulone are extracted from barley malt and hop, respectively, based on the brewing process. Mixtures of protein and iso-humulone are mixed at different concentrations and centrifuged.

Assessment of amyloid deposits is a critical step for the identification of Alzheimer disease (AD) signature in asymptomatic elders. Whether the different amyloid processing methods impacts on the quality of clinico-radiological correlations is still unclear. We directly compared in 155 elderly controls with extensive neuropsychological testing at baseline and 4.5 years follow-up three approaches:

The paper aims to identify and analyse potential legal avenues for phasing out fossil fuels in the European Union using EU State aid rules. Our analysis of the EU’s legal framework reveals that the EU State aid rules would allow the European Commission to effectively target and monitor fossil fuel subsidies. In particular, the requirements for notification, examination, transparency, reporting, an