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Somatic variations are frequent and important drivers in cancers. Amino acid substitutions can yield neoantigens that are detected by the immune system. Neoantigens can lead to immune response and tumor rejection. Although neoantigen load and occurrence have been widely studied, a detailed pan-cancer analysis of the occurrence and characterization of neoepitopes is missing. We investigated the pro
Child perspective on being summoned to, visiting and exiting Barnahus Aim This study forms an essential part in informing effective prevention and interventions with children exposed to or at risk of domestic violence and sexual abuse, focusing on children becoming summoned, visiting and exiting Barnahus with a child perspective. Background In Sweden when custodians are under suspicion, the child
This paper examines the response of five prominent Swedish economists, David Davidson, Gustav Cassel, Eli Heckscher, Knut Wicksell and Bertil Ohlin, to John Maynard Keynes’s "The Economic Consequences of the Peace" and to the German reparations in the 1920s. When Keynes’s book appeared, Davidson and Cassel strongly endorsed it. Heckscher also agreed with Keynes – “a bright spot in a time of darkne
Background: The optimal criteria to diagnose gestational diabetes mellitus (GDM) remain contested. The Swedish National Board of Health introduced the 2013 WHO criteria in 2015 as a recommendation for initiation of treatment for hyperglycaemia during pregnancy. With variation in GDM screening and diagnostic practice across the country, it was agreed that the shift to new guidelines should be in a
Evacuation planning is an important activity in disaster management to reduce the effects of disasters on urban communities. It is regarded as a multi-objective optimization problem that involves conflicting spatial objectives and constraints in a decision-making process. Such problems are difficult to solve by traditional methods. However, metaheuristics methods have been shown to be proper solut
Abnormal patterns of proliferation characterize the behavior of many tumors. Proliferating cell nuclear antigen (PCNA) and Ki‐67 are two cell cycle antigens which are expressed in proliferative states. Our study examines the prognostic value of these cell‐cycle antigens in soft tissue sarcoma (STS). Paraffin‐embedded primary tumor tissues from 185 patients (1980–92) were stained with the anti‐PCNA
Although intimate partner violence is far from a new problem in society, it has lately gained increased attention both by governments and by the research community. In 2007, the Swedish government issued an action plan for “combating men’s violence against women, violence and oppression in the name of honour and violence in same-sex relationships” (2007/08:39), which included a call for increased
Follicular lymphoma (FL) is a heterogeneous disease with varying prognosis owing to differences in clinical, laboratory, and disease parameters. Although generally considered incurable, prognosis for early- and advanced-stage disease has improved because of therapeutic advances, several of which have resulted from elucidation of the biologic and molecular basis of the disease. The choice of treatm
Objective: The aim of this study is to assess the impact of age at onset on the prognostic value of Alzheimer’s biomarkers in a large sample of patients with mild cognitive impairment (MCI). Methods: We measured Aβ42, t-tau, hippocampal volume on magnetic resonance imaging (MRI) and cortical metabolism on fluorodeoxyglucose–positron emission tomography (FDG-PET) in 188 MCI patients followed for at
Background. Recent studies have associated the transcription factors, Oct4, Sox2 and Nanog as parts of a self-regulating network which is responsible for maintaining embryonic stem cell properties -- self renewal and pluripotency. In addition, mutual antagonism between two of these and other master regulators have been shown to regulate lineage determination. In particular, an excess of Cdx2 over
This study is about how the 'global' becomes localized and how the 'local' is articulated through the 'global'. It deals with the Van (forest) Gujjars, a people of nomadic forest pastoralists who inhabit the Central Himalayas of India. The study has two main foci: One is the everyday life-world of the Van Gujjars in the forest - a Van Gujjar ethnography - and the other is the conflict over 'conser
Popular Abstract in Swedish När ett barn föds före graviditetsvecka 30 är andningsinsufficiens eller på engelska kallad respiratory distress syndrome (RDS) ett av de stora kliniska problemen som barnläkaren står inför. Redan på 1920-talet förstod man att det måste finnas ett ytspänningsnedsättande ämne i lungorna och på 1950-talet fann man att för tidigt födda (prematura) barn med RDS hade brist p
The need for new renewable products has enhanced the interest in cellulose and hemicellulose as raw material. The wood plant cell wall is a complex mixture of cellulose, hemicellulose, lignin and minor amounts of pectin, proteins and extractives. Several interactions between the compounds make them difficult to separate without modification. O-acetyl-galactoglucomannan (O-acetyl-GGM), the major he
Popular Abstract in Swedish Populärvetenskaplig sammanfattning Vilka är egentligen ”de äldre”? Vad innebär det att vara pensionär? Hur ska man åldras på rätt sätt? Frågor som dessa har under det nyss avslutade århundradet ställts och besvarats på många oliks sätt, beroende av sammanhang och tidsperiod. I vissa situationer har de äldres olikhet lyfts fram, i andra deras likhet. Ibland har åldrandetThe aim of the dissertation is to describe images of old age in the magazines of Sweden’s two largest pensioner organizations, and explain the character of those images in relation to the temporal contexts of the organizations and their aim to act as the representatives of pensioners. The study is based on the 329 and 330 magazines (1941–1995) that the organizations have submitted to attract membe
A green house experiment was designed to test the idea that competition for inorganic nitrogen (N) between plants and heterotrophic microorganisms occurs in soils with high C:N ratios, qualifying for N limited microbial activity, but not at low C:N ratios. The short- term (24 h) N-15 uptake by the grass Festuca gigantea and microorganisms in planted and unplanted soils was determined, and the bact
The aim of this study was to evaluate the validity and reliability of homeostasis model assessment-insulin resistance (HOMA-IR) index, its reciprocal (1/HOMA-IR), quantitative insulin sensitivity check index (QUICKI) and McAuley's index in hypertensive diabetic patients. In 78 patients with hypertension and type II diabetes glucose, insulin and triglyceride levels were determined after a 12-h fast
A list of 1719 chemical compounds identified from headspace samples of floral scent is presented. The list has been compiled from some 270 published papers, including analyses of 991 species of flowering plants and a few gymnosperms, a sample including seed plants from 90 families and 38 orders. The compounds belong to seven major compound classes, of which the aliphatics, the benzenoids and pheny
We present two new methods for finding a lowest common ancestor (LCA) for each pair of vertices of a directed acyclic graph (dag) on n vertices and m edges. The first method is surprisingly natural and solves the all-pairs LCA problem for the input dag on n vertices and m edges in time 0 (n m). The second method relies on a novel reduction of the all-pairs LCA problem to the problem of finding max
Time domain reflectometry (TDR) is a widely used method for measuring the dielectric constant (K-a) and bulk electrical conductivity (sigma(a)) in soils. The TDR measured sigma(a) and K-a can be used to calculate the soil solution electrical conductivity, sigma(w.) The sigma(w), in turn, can be related to the concentration of an ionic tracer. Several models of the sigma(w)-sigma(a)-K-a relationshi
