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Background: nonacog beta pegol (N9-GP) is a glycoPEGylated recombinant factor IX (rFIX) molecule with a prolonged half-life. Objectives: To provide information on potential dose regimens for N9-GP for phase 3 pivotal and surgery trials. Methods: A population pharmacokinetic model was developed from single-dose data derived from the first human dose trial with N9-GP in hemophilia B patients, and wa

The effect of changing climatic conditions on wild populations has been the subject of much recent research. Most attention has been on the direct effects of climate changes on species of lower trophic levels and on the negative consequences of climate change. However, a deeper understanding of how climate change affects apex predators is vital, as they are keystone species that have a disproporti

Abstract. Purpose: To compare the performance of two machine learning classifiers (MLCs), artificial neural networks (ANNs) and support vector machines (SVMs), with input based on retinal nerve fibre layer thickness (RNFLT) measurements by optical coherence tomography (OCT), on the diagnosis of glaucoma, and to assess the effects of different input parameters. Methods: We analysed Stratus OCT data

PURPOSE: The purpose of this study was to analyze three models of how patient-reported outcome measures can be connected to clinical outcome measures in cataract surgery to identify opportunities for improvement of quality of care. METHODS: Three models were used to analyze the following questions: Is there a relationship between clinical parameters and patient-reported outcomes? (1) Is there a re

Abstract in UndeterminedBone consists of an organic and an inorganic matrix. During development, bone undergoes changes in its composition and structure. In this study we apply three different cluster analysis algorithms [K-means (KM), fuzzy C-means (FCM) and hierarchical clustering (HCA)], and discriminant analysis (DA) on infrared spectroscopic data from developing cortical bone with the aim of

This longitudinal study used a multi-disciplinary approach and examined the relationship between psychosocial and health characteristics and the pattern of informal and formal support for non-institutionalized very old people. The data were derived from a single cohort of 80-year-old people living in Lund, Sweden who were followed over a 3-year period. In order to account for potential sample bias

OBJECTIVE: To compare ambulatory blood pressure recorded during a work day with a leisure day regarding masked hypertension. DESIGN: A randomized crossover study in middle-aged normotensives. PARTICIPANTS: Thirty-seven untreated middle-aged normotensives (17 women), who had repeated office blood pressure less than 140/90 mmHg. MAIN OUTCOME MEASURE: Individual difference of masked hypertension betw

Solar shading devices can significantly reduce cooling loads, improve thermal comfort and reduce potential glare problems in commercial buildings. However, measured data or tools to facilitate a comparison among various shading devices have previously not been available to designers. The Solar Shading Project at Lund University was initiated in 1997 to increase the knowledge on shading devices. Th

Biological nutrient removal processes for municipal wastewaters have received quite some attention during the past decades, especially due to the introduction of stricter legislation with respect to allowable effluent pollutant discharge limits. The necessity for performance improvement of existing activated sludge wastewater treatment plants (ASWWTPs) has created a need for detailed process model

AIM: To prospectively validate two mathematical models for calculating the likelihood of endometrial malignancy in patients with postmenopausal bleeding (PMPB), sonographic endometrial thickness (ET) ≥4.5 mm and no fluid in the uterine cavity.METHODS: This is a prospective observational diagnostic validation study performed in a PMPB clinic in a university hospital. Of 860 consecutive patients, 35

BACKGROUND: Antibiotic resistance is a serious global public health problem directly correlated to high antibiotic consumption. Romania is one of the European countries with the highest rates of antibiotic consumption, non-prescription antibiotics use and resistance of several pathogens to antibiotics. Pharmacists are an important stakeholder in respect to antibiotic management and context specifi

Popular Abstract in English As there is a demand for new antibacterial agents due to antimicrobial resistance, the ability of one kind of microorganisms to produce antimicrobial substances has been evaluated. Then, after determining the antibacterial-producer microorganism, the production of active compound in large scale, followed by optimization the conditions investigated. Next, the bioactive aForty alkaliphiles, which were isolated from samples collected in Eastern Africa, have been screened for production of antibacterial compounds. One of these isolates, Bacillus halodurans B20, was able to produce a prominent amount of antibacterial activity against a Gram-positive bacteria on agar plates [paper I] and selected for further study. Production of the active compound in submerged culti

We study the determinants of remittances to developing countries at different time horizons. Remittances to developing countries nowadays exceed official development assistance and constitute a significant fraction of the disposable income of many households in developing countries. Different hypotheses suggest that remittances are often sent to compensate for low incomes, which may impose a downw

With the growing integration of renewable energy sources into the power grid, new challenges for system stability have emerged. To address this, the European Union has introduced a regulation called Requirements for Generators (RfG). This regulation sets specific performance standards, one of which is a minimum critical clearing time related to faults. Some production facilities with low inertial

Levels of carbon dioxide (CO2) and other greenhouse gases (GHG) are rising, thereby acceler-ating global warming and related effects on the environment. Forests are an important ecosystem and can act as carbon sinks, providing a buffer against these effects. However, disturbances such as clearcutting can turn the forests into carbon sources. In this project, the effects of clearcutting on the carb