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Popular Abstract in Swedish Vi har undersökt hur och varför streptokocker orsakar sjukdom. Vi började med att undersöka hur proteiner på bakterieytan interagerar med det så kallade kontaktsystemet, som är en del av immunförsvaret och blodlevringen. Vi fann att det bildades en inflammatorisk signalmolekyl och ett bakteriedödande proteinfragment men bakteriens ytproteiner skyddade mot det. Att bakteThis thesis explores streptococcal virulence from both mechanistic and evolutionary perspectives, where the mechanistic studies focus on interactions with the human coagulation system. We describe interactions between streptococcal surface proteins and components of the intrinsic pathway of coagulation and the kallikrein-kinin system in human plasma, as well as to how these surface proteins are pr

ATP Binding Cassette B1 (ABCB1) is a transporter with a broad substrate specificity involved in the elimination of several carcinogens from the gut. Several polymorphic variants within the ABCB1 gene have been reported as modulators of ABCB1-mediated transport. We investigated the impact of ABCB1 genetic variants on colorectal cancer (CRC) risk. A hybrid tagging/functional approach was performed t

Heat transfer and flow characteristics of six ribbed channels of square cross section having different rib structure are computed with the objective of improving heat transfer in the lee-side of the ribs. Six ribs are installed on the bottom walls of each channel. The rib pitch-to-height ratio (P/e) is 10. Details of the turbulent flow structure, temperature fields, local heat transfer coefficient

AIM AND OBJECTIVE: To describe the study design of a randomised controlled trial with the aim of comparing two different regimes for children with newly diagnosed type 1 diabetes; hospital-based care and hospital-based home care. BACKGROUND: Procedures for hospital admission and sojourn in connection with diagnose vary greatly worldwide and the existing evidence is insufficient to allow for any c

Amplification of 8p12-p11 is relatively common in breast cancer and several genes within the region have been suggested to affect breast tumor progression. The aim of the study was to map the amplified 8p12-p11 region in a large set of breast tumors in an effort to identify the genetic driver and to explore its impact on tumor progression and prognosis. Copy number alterations (CNAs) were mapped i

This study has sought to propose didactical approaches to find a balance between the teaching of classic and contemporary literature in the Swedish EFL classroom by exploring and comparing the attitudes of Swedish upper secondary school teachers and students towards both forms of literature. The study was conducted through two quantitative questionnaires, one researching the attitudes of 44 EFL st

As more and more In Vitro Fertilizaiton (IVF) treatments are performed each year, there is a need to better predict the outcomes of different stages of the treatment and hence get a better understanding of which hormonal and physical parameters affect the treatment outcome and in what way. In this study, the effect of interaction between baseline AMH (anti-mullerian hormone) and DFI (DNA fragmenta

Det får anses vedertaget att barn är en särskilt utsatt grupp världen över. Gifta barn, som dessutom är asylsökande, är alldeles särskilt sårbara. Insikten om detta bör genomsyra all lagstiftning som avser barn, där barnets bästa ska sättas i främsta rummet. Uppsatsens övergripande syfte har varit att undersöka ett i utlandet gift barns rätt att i Sverige återförenas med sina föräldrar. Syftet ha

Barnkonventionens artikel 3 och 12 ger uttryck för två centrala principer inom barnrätten, vilka även är fastställda i andra svenska lagar som föräldrabalken och lagen med särskilda bestämmelser om vård av unga. Principen om barnets bästa innebär att vid samtliga åtgärder som rör barn ska barnets bästa vara avgörande. Vid denna bedömning ska varje barn få chansen att uttrycka sina åsikter, vilka s

Uppsatsens fokus kommer ligga på de två stora principerna som genomsyrar barnkonventionen och därav också den svenska barnrätten. Barnets bästa som framkommer av artikel 3 och även barnets vilja som stadgas i artikel 12 barnkonventionen. En undersökning gällande hur artikel 3 kan tolkas görs för att vidare kunna öppna för diskussion. Frågan gällande om vaga rekvisit som argumenteras för att skapa

Denna uppsats utgår från premissen att barns rätt till integritet är en del av barns rätt till deltagande online. Barnrättslagstiftning presenterar i sig ett di-lemma som rör barns rätt till delaktighet och skydd, där en rättighetsbaserad strategi anses vara det mest effektiva sättet att ta itu med dilemmat. En rättig-hetsbaserad strategi förespråkar en balans mellan barns behov av skydd online ocThis thesis starts from the premise that children’s right to privacy is a part and parcel for children’s right to participation online. Children’s rights law inher-ently presents a dilemma relating to children’s right to participation and protec-tion, where a rights-based approached is considered the most effective way to address the dilemma. A rights-based approach is legal framework that can bal

Entrepreneurship education has grown rapidly and there is a steady increase in entrepreneurship courses and programs worldwide. For the past decade, research topics in entrepreneurship education have mainly been related to the entrepreneurial intentions, actions, and learning process of students. However, not much research related to entrepreneurship educators has been conducted. Specifically, the

Kraftringens geotermianläggning i Lund har varit i drift sen 1984. Det är den enda stora geoter-miska anläggningen i Sverige. Efter mer än 30 års drift är det dags att utvärdera hur det har fungerat. Arbetet be-skriver de geologiska förutsättningarna som stratigrafi (formation), formationstemperatur, typ av akvifer, porositet, permeabilitet och vattenkemi, samt driftdata, systemuppbyggnad, funktioThe geothermal heat plant in Lund has been running since 1984. It is the only one of its kind in Sweden. After running for more than 30 years it’s now time to evaluate the experiences from the long operational period of the heat plant. This report describes the geological conditions like the formation, temperature of the geothermal water, aquifer, porosity, permeability, and chemistry of the forma

Today’s human population is continuously increasing and this also increases the need of exploiting natural habitats. Increased exploitation results in loss of important habitats for different organisms, which in turn leads to biodiversity loss. The loss of biodiversity endangers the supply of ecosystem services, which is fundamental for human well-being. To mitigate the loss of biodiversity and ec

Ett för entreprenadavtalet utmärkande drag är beställarens ändringsbefogenhet, vilken innebär att beställaren under entreprenadtidens gång har möjlighet att ändra avtalets omfattning. Att utnyttjandet av ändringsbefogenheten vanligen medför produktionsförluster för entreprenören är den generella uppfattningen i branschen. Ersättning för denna typ av kostnader går att utfå med hjälp av AB 04 kap. 6A distinctive feature of the construction contract is the client’s authority to change the scope of the agreement. The fact that the use of the change authority usually entails production losses for the contractor is the general perception of the industry. Compensation for this type of costs can be obtained according to AB 04 chapter 6, clause 5, when a change order or a change in relation to the

As incidences of chronic diseases increase, the tools to diagnose, treat and monitor such conditions become more important. Medical imaging technologies, being one of these tools, still face challenges in safe and effective use. At the same time, poor design of medical devices causes errors that could be avoided using proper design methods. The master thesis is written in collaboration with Bild

As computer systems grow larger and more complex, the task of maintaining the system and finding potential security threats or other malfunctions become increasingly hard. Traditionally, this has had to be done by manually examining the logs. In modern systems, this can become infeasible due to either the large amount of logs or the complexity of the system. By using machine learning based anomaly

Data is a crucial resource for machine learning. But in many settings, such as in healthcare or on mobile devices, there are obstacles that make it difficult to utilize the available data. This data is often distributed between many clients and private, meaning that central storage of the data is inadvisable. Further, image data is often unlabeled and external labelling is impossible due to its pr

Continuous production control is important for the production using Tetra Pak equipment, as problems that are found early in the chain of production can minimize the need for waste greatly. In production of paper straws, a possible production control could be to photograph straws during production, analyse these and predict how good the straw is, using the image. If the predicted performance of th