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A theoretical analysis of the microdialysis ethanol technique in skeletal muscle is presented, and a model governing the transport of ethanol from the microdialysis probe to the capillaries in the muscle tissue is proposed. The model is derived under the assumption of a steady-state situation, and an analytical solution is found for the outflow-to-inflow ratio of ethanol in the perfusate. Theoreti
Studies on nonlinear electron transport in nanometer-sized semiconductor devices with broken centrosymmetry are reviewed. In these devices, an applied alternating (rocking) electric field induces a net flow of electrons in the direction perpendicular to that of the applied field. Such an electron ratchet effect has been observed in a number of differently designed devices, fabricated from two type
The meniscus is a critical tissue in the healthy knee joint because of its shock absorption and load distribution properties. Meniscal damage is a frequent finding on MRI of the osteoarthritis (OA) knee. The damage appears as horizontal, flap, or complex tears; meniscal maceration; or destruction. Asymptomatic meniscal lesions are common incidental findings on knee MRI of the middle-aged or older
We analyzed 3,872 common genetic variants across the ESR1 locus (encoding estrogen receptor α) in 118,816 subjects from three international consortia. We found evidence for at least five independent causal variants, each associated with different phenotype sets, including estrogen receptor (ER(+) or ER(-)) and human ERBB2 (HER2(+) or HER2(-)) tumor subtypes, mammographic density and tumor grade. T
Working memory, language, and reading comprehension are strongly associated in children with severe and profound hearing impairment treated by cochlear implants (CI). In this study we explore this relationship in sixteen Swedish children with CI. We found that over 60% of the children with CI performed at the level of their hearing peers in a reading comprehension test. Demographic factors were no
We consider a MIMO system where error-prone feedback from the receiver is used by the transmitter to select a single optimum antenna to transmit data. Such error-prone feedback is common in the bandwidth-limited real systems, and is in marked contrast with the idealizations assumed in the selection literature. We show how the signaling assignment, which maps the antenna indices to the codewords th
A new method for extraction of general features in ECGs with atrial tachyarrhythmias is presented. The method is based on our recent method for atrial signal characterization which sequentially decomposes a time-frequency distribution into a set of parameters. In addition to rate and amplitude, the method tracks information on regularity, waveform, and structure of the atrial signal. The proposed
Transfer of melanin-containing melanosomes from melanocytes to neighboring keratinocytes results in skin pigmentation. To provide a more practical method of visualizing melanosomes in melanocytes as well as in keratinocytes, we attempted to use murine cell lines instead of human primary cells. We generated various fluorescent fusion proteins of tyrosinase, a melanin synthesis enzyme located in the
Anaplasma platys was first identified and described in North America as a Rickettsia-like, platelet-specific organism in dogs with infectious canine cyclic thrombocytopenia. In Europe, A. platys has so far mainly been described for some Mediterranean countries. Here, we describe a case of A. platys infection in a dog from Romania, confirmed by PCR. Additionally, the dog had a co-infection with Hep
An important challenge in the design and implementation of self-optimizing systems is that of finding a model that maps changes in a tunable parameter (or “knob”) into an effect on the performance, power, or energy, of the overall system. This paper describes ARPE (Analyzing the Relationship between Parameters and Effectors), an open source tool to analyze the effect of parameter changes on the be
