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Analysis of the molecular interplay between Streptococcus pyogenes and its human host
The common human pathogen Streptococcus pyogenes is the causative agent of numerous mild and severe clinical conditions. It expresses a number of secreted or cell wall-anchored proteins that modulate the human immune system and facilitate colonization and spread of the pathogen in the human host. During S. pyogenes infections, human plasma leaks into the site of infection as a consequence of infl
Homozygosity for the IgG2 subclass allotype G2M(n) protects against severe infection in hereditary C2 deficiency
Homozygous C2 deficiency (C2D) is the most common deficiency of the classical complement pathway in Western countries. It is mostly found in patients with autoimmune disease or susceptibility to bacterial infections and in healthy persons. We wished to assess to what extent other immunological factors might explain differences of susceptibility to infections in C2D. For this reason, 44 Swedish pat
BspK, a serine protease from the predatory bacterium Bdellovibrio bacteriovorus with utility for analysis of therapeutic antibodies
The development of therapeutic and diagnostic antibodies is a rapidly growing field of research, being the fastest expanding group of products on the pharmaceutical market, and appropriate quality controls are crucial for their application. We have identified and characterized the serine protease termed BspK (Bdellovibrio serine protease K) from Bdellovibrio bacteriovorus and here show its activit
The IgG-degrading enzyme of Streptococcus pyogenes causes rapid clearance of anti-glomerular basement membrane antibodies in patients with refractory anti-glomerular basement membrane disease
In anti-glomerular basement membrane (anti-GBM) disease, IgG class autoantibodies induce rapidly progressive glomerulonephritis. Regrettably, many patients are diagnosed at a late stage when even intensive conventional treatment fails to restore renal function The endopeptidase IdeS (Immunoglobulin G degrading enzyme of Streptococcus pyogenes) (imliflidase) rapidly cleaves all human IgG subclasses
The derivation of first- and second-order backpropagation methods for fully-connected and convolutional neural networks
We introduce rigorous theory for deriving first and second order backpropagation methods for Deep Neural Networks (DNN) whilst satisfying existing theory in DNN optimization. We begin by formally defining a neural network with its respective components and state the first and second order chain rule with respect to its partial derivatives. The partial derivatives in the chain rule formula are rela
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https://goteborgonline-my.sharepoint.com/personal/peter_jonsson_educ_goteborg_se/Documents/C%20e%20n%20t%20r%20a%20l%20a%20%20%20S%20a%20c%20o%20r%20å%20d%20e%20t%20%20%20i%20%20%20G%20ö%20t%20e%20b%20o%20r%20g%20s%20%20%20S%20t%20a%20d/AU/SKOT/C%20E%20N%20T%20R%20A%20L%20A%20%20%20S%20A%20C%20O%20R%20Å%20D%20E%20T%20%20%20I%20N%20F%20O%20R%20M%20E%20R%20A%20R/December%202024/www.saco.se/goteborg
I2p lab open day
Open Day Come and Visit our Idea to Product Lab! 18 November 2015, 8:30 – 16:30 Dear All, LTH recently acquired a high-end selective laser sintering system (3D printer) that forms the basis of a powerful new additive manufacturing facility at Lund University. We cordially invite you to come and visit the Idea to Product Lab get a better idea of what our 3D printing facilities can do for you! Our a
https://www.lu.se/sites/www.lu.se/files/i2p_lab_open_day.pdf - 2026-05-09
Lab-scale versus industrial-scale thermal runaway tests for lithium-ion battery cells
Lithium-ion battery safety is a topic of large importance, and testing is associated with large costs. Safety evaluation is therefore needed also at an early stage in cell design and development, in order to evaluate potential short-comings or to screen large platforms of materials and cells. Previous thermal runaway tests on lab-scale cells have, however, indicated differences in heat release and
Settings for Site Message and Site Alert
Sometimes you may need to communicate with your website visitors in a different way than through your regular content. When you have important information, you can use the site alert and site message features. These are two types of static messages that appear at the top of the website. Site alertWith site alerts, you can use different types of status messages depending on the type of information
https://www.webbpublicering.lu.se/guides-english/settings-site-message-and-site-alert - 2026-05-07
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Alla webbplatser som skapas i Drupal får automatiskt två nyhetssidor. På den här webbplatsen benämns de som 'Nyhetssidan' och 'Nyhetsarkivet'. Här kan du läsa om vilka inställningar du kan göra på dessa sidor. Drupal skapar två sidor helt automatiskt som är kopplade till nyhetsartiklar som publiceras på webbplatsen: Sidan Nyheter/Latest news, där utvalda artiklar syns, med adressen xxx.lu.se/newsS
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Energy Storage & Conversion
Sustainable energy storage and conversion explores innovative methods to efficiently store and transform energy from various renewable sources. It focuses on technologies like advanced batteries, hydrogen production, fuel cells, and thermochemical systems as well as safety aspects of battery storage systems. Research aims to enhance energy density, reduce costs, and improve scalability, enabling r
https://www.energy.lth.se/research/energy-storage-conversion - 2026-05-07
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Efficacy of T-cell assays for the diagnosis of primary defects in cytotoxic lymphocyte exocytosis
Primary hemophagocytic lymphohistiocytosis (HLH) is a life-threatening disorder associated with autosomal recessive variants in genes required for perforin-mediated lymphocyte cytotoxicity. A rapid diagnosis is crucial for successful treatment. Although defective cytotoxic T lymphocyte (CTL) function causes pathogenesis, quantification of natural killer (NK)–cell exocytosis triggered by K562 targe
Structural determination of Streptococcus pyogenes M1 protein interactions with human immunoglobulin G using integrative structural biology
Streptococcus pyogenes (Group A streptococcus; GAS) is an important human pathogen responsible for mild to severe, life-threatening infections. GAS expresses a wide range of virulence factors, including the M family proteins. The M proteins allow the bacteria to evade parts of the human immune defenses by triggering the formation of a dense coat of plasma proteins surrounding the bacteria, includi
Results of a phase I/II study of ocrelizumab, a fully humanized anti-CD20 mAb, in patients with relapsed/refractory follicular lymphoma
Background: Ocrelizumab is a humanized anti-CD20 antibody with increased antibody-dependent cellular cytotoxicity compared with rituximab. This phase I/II study evaluated its safety and efficacy in patients with relapsed/refractory follicular lymphoma (FL) after prior rituximab therapy. Design and methods: Forty-seven patients were treated in three dose cohorts and received eight infusions every 3
Sushi domain-containing protein 4 (SUSD4) inhibits complement by disrupting the formation of the classical C3 convertase.
Streptococcus pyogenes secreted enzymes interacting with the human host
Streptococcus pyogenes is one of the most common bacteria infecting humans. One of the factors contributing to the disease-causing properties is the secreted streptococcal cysteine proteinase, SpeB, which degrades several host proteins in connective tissue and circulation. SpeB activity depends on the transformation from an inactive precursor, zymogen, into a mature proteinase. We show that