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Aims/hypothesis: Coronary artery disease (CAD) is a common complication among individuals with diabetes. A better understanding of the genetic background of CAD in this population has the potential to suggest novel molecular targets for screening, risk assessment and drug development. Methods: We performed a genome-wide association study of CAD in 15,666 unrelated individuals (3,968 CAD cases and
The metabolism of individual polyunsaturated fatty acids (PUFA) may be influenced differently by nutritional status and nutritional intake. In normal rats, radioactive arachidonic acid (20:4(n-6), is preferentially retained in tissue phospholipids compared to linoleic (18:2(n-6), or eicosapentaenoic acid (20:5(n-3). This study compares the fate of 20:4(n-6) and 20:5(n-3) acids in essential fatty a
The laccase producing fungus HC1 was isolated from a sample collected in the Bolivian Amazon region. Analysis of 5.8S and 28S rDNA, and internal transcribed spacer 1 and 2 sequences revealed that isolate HC1 belongs to genus Galerina. High production of laccase was achieved in basal salt medium supplemented with 30 g L-1 glucose, 10 g L-1 yeast extract and 0.01 g L-1 co
Increasing atmospheric carbon dioxide concentration [CO2] caused by anthropogenic activities has triggered a requirement to predict the future impact of [CO2] on forests. The Hindu Kush Himalayan (HKH) region comprises a vast territory including forests, grasslands, farmlands and wetland ecosystems. In this study, the impacts of climate change and land-use change on forest carbon fluxes and vegeta
High-frequency in situ measurements at Gosan (Jeju Island, Korea) during November 2007 to December 2008 have been combined with interspecies correlation analysis to estimate national emissions of halogenated compounds (HCs) in East Asia, including the chlorofluorocarbons (CFCs), halons, hydrochlorofluorocarbons (HCFCs), hydrofluorocarbons (HFCs), perfluorocarbons (PFCs), sulfur hexafluoride (SF6),
Oxidative stress plays a crucial role in the development of several liver diseases. Many natural polyphenols can attenuate oxidative stress and liver injury. In this study, a phytochemical profiling of a methanol extract from leaves of Syzygium samarangense revealed 92 compounds belonging to flavonoids, phenolic acids, condensed tannins, and ellagitannins. The S. samarangense extract exhibited a n
AIMS: Unexplained syncope is an important clinical challenge. The influence of age at first syncope on the final syncope diagnosis is not well studied.METHODS AND RESULTS: Consecutive head-up tilt patients (n = 1928) evaluated for unexplained syncope were stratified into age groups <30, 30-59, and ≥60 years based on age at first syncope. Clinical characteristics and final syncope diagnosis were an
Background: Cadmium (Cd) exposure during gestation has been associated with altered DNA methylation at birth, but it is not known if the changes in methylation persist into childhood. Objectives: To evaluate whether gestational Cd-related changes of DNA methylation persist from birth to 9 years of age. Methods: We studied mother–child dyads in a longitudinal cohort in rural Bangladesh. Cadmium con
Activating Notch1 mutations have been reported in human T-line-age acute lymphoblastic leukemia (T-ALL) and lymphomas from genetically modified mice. We report that Notch1 is a prevalent and major mutational target in chemically induced mouse lymphoma. The regions of the gene that are frequently mutated are the heterodimerization domain and the N-terminal ligand-binding region, important for prote
OBJECTIVE: To quantify the risks of mortality, morbidity and postnatal characteristics associated with extreme preterm fetal growth restriction (EP-FGR).DESIGN: The EVERREST (Do e s v ascular endothelial growth factor gene therapy saf e ly imp r ove outcome in seve r e e arly-onset fetal growth re st riction?) prospective multicentre study of women diagnosed with EP-FGR (singleton, estimated fetal
Background: Asundexian (Bayer AG, Leverkusen, Germany), an oral small molecule factor XIa (FXIa) inhibitor, might prevent thrombosis without increasing bleeding. Asundexian's effect for secondary prevention of recurrent stroke is unknown. Methods: In this randomised, double-blind, placebo-controlled, phase 2b dose-finding trial (PACIFIC-Stroke), patients with acute (within 48 h) non-cardioembolic
Popular Abstract in Swedish I Sverige är intaget av kostfiber lågt. Endast 5‒20% av alla vuxna uppnår det rekommenderade dagliga intaget. Fiberrika livsmedel bör utgöra en stor del av en hälsosam diet eftersom man har visat att det finns ett samband mellan högt fiberintag och minskad risk för välfärdssjukdomar såsom hjärt-kärl sjukdomar och typ 2 diabetes. Kostfibrer kan till exempel sänka ditt onThe spread of lifestyle-related diseases has become epidemic throughout the world. Impaired glucose metabolism and high levels of plasma cholesterol are risk factors for the development of type 2 diabetes and cardiovascular disease respectively. Soluble dietary fibers from plants, algae and mushrooms have been shown to positively regulate both glucose- and cholesterol metabolism indicating their v
Introduction: Although ischemic stroke incidence has decreased in Sweden over the past decade, trends in spontaneous intracerebral hemorrhage (ICH) incidence are less well delineated. In this time period, there has been a dramatic increase in use of oral anticoagulants (OAC). The aim of our study was to investigate incidence trends in spontaneous first-ever ICH in Sweden between 2010 and 2019, wit
This is a study of seven men that have suffered from a cruel punishment. The punishment involved getting their ear/ears cut off, prison with more torture and their families being deported from their homes to another town. My sample involved seven Iraqi men who suffered from this punishment during Saddams regime, they got this punishment because they refused to fight against Iran and Kuwait. I wen
Background: Although it has been suggested that the hippocampus and amygdala (HA) are involved in the neurobiology of obsessive– compulsive disorder (OCD), volumetric findings have been inconsistent, and little work has been undertaken on the volumetry of the heterogeneous anatomic units of HA, with their specific functions and cytoarchitecture, in OCD. We sought to explore potential sources of he
Reumatologi Reumatologi är en vårdspecialitet som befinner sig i en dynamisk utveckling. Kunskapsmassan har ökat snabbt under senaste år och likaså kraven på dem som ägnar sig åt reumatologi. Den reumatologiska omvårdnaden har blivit alltmer komplex och sjuksköterskans roll har successivt utvidgats med avancerade arbetsuppgifter som förutsätter fördjupade kunskaper. Inom specialiteten är det också
https://www.medicin.lu.se/sites/medicin.lu.se/files/reumatologi_20190506.pdf - 2026-07-18
