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Cyclic nucleotide phosphodiesterases (PDEs): diverse regulators of cyclic nucleotide signals and inviting molecular targets for novel therapeutic agents

Introduction: Cyclic adenosine 3’5’-monophosphate (cAMP) and cyclic guanosine 3’5’-monophoshpate (cGMP) are critical intracellular second-messengers involved in the transduction of a wide variety of extracellular stimuli, including peptide hormones, growth factors, cytokines, neurotransmitters and light. These messengers modulate many fundamental biological processes, including growth, differentia

Integrating the influence of weather into mechanistic models of butterfly movement

Background: Understanding the factors influencing movement is essential to forecasting species persistence in a changing environment. Movement is often studied using mechanistic models, extrapolating short-term observations of individuals to longer-term predictions, but the role of weather variables such as air temperature and solar radiation, key determinants of ectotherm activity, are generally

Cancer risk in patients with spondyloarthritis treated with TNF inhibitors : A collaborative study from the ARTIS and DANBIO registers

Background Safety data on cancer risks following tumour necrosis factor a inhibitors (TNFi) in patients with spondyloarthritis (SpA) (here defined as ankylosing spondylitis (AS), undifferentiated spondarthropaties (SpA UNS), psoriatic arthritis (PsA)) are scarce. Our objective was to assess risks for cancer overall and for common subtypes in patients with SpA treated with TNFi compared with TNFi-n

Cytoplasmic Estrogen Receptor in Breast Cancer

Purpose: In addition to genomic signaling, it is accepted that estrogen receptor-alpha (ER alpha) has nonnuclear signaling functions, which correlate with tamoxifen resistance in preclinical models. However, evidence for cytoplasmic ER localization in human breast tumors is less established. We sought to determine the presence and implications of nonnuclear ER in clinical specimens. Experimental D

Swedish Butterfly Monitoring Scheme, annual report for 2012

This is the third annual report of the Swedish Butterfly Monitoring Scheme, a national monitoring programme coordinated by Lund University for the Swedish Environmental Protection Agency since 2010. The programme is a partnership between the Entomological Society of Sweden, the Swedish Environmental Protection Agency, Lund University, the Swedish University of Agricultural Sciences and the Swedish

Trajectory of excess healthcare consultations, medication use, and work disability in newly diagnosed knee osteoarthritis : a matched longitudinal register-based study

PURPOSE: To estimate the excess healthcare use and work disability attributable to knee osteoarthritis (OA) in the first five years following diagnosis.METHODS: Among individual aged 40-80 years who resided in Skåne on 31st December 2008, we identified those with a main diagnosis of knee OA during 2009-2014 and no previous diagnosis of any OA from 1998 (n=16,888). We created a comparison cohort ma

Design and baseline characteristics of the simvastatin and ezetimibe in aortic stenosis (SEAS) study

Aortic valve stenosis and, atherosclerotic disease have several risk factors in common, in particular, hypercholesterolemia. Histologically, the diseased valves appear to have areas of inflammation much like atherosclerotic plaques. The effect of lipid-lowering therapy on the progression of aortic stenosis (AS) is unclear, and there are no randomized treatment trials evaluating cardiovascular morb

Occupational exposures and risk of gastric cancer in a population-based case-control study

Gastric cancer trends seem to follow improvements in the environment of blue-collar workers, but the etiological role of occupational exposures in gastric carcinogenesis is scantily investigated. The risk of gastric adenocarcinoma in 10 common occupational industries, and particularly the long-term effects of asbestos, organic solvents, impregnating agents, insecticides, and herbicides, were evalu

Characterization of Hairdresser Exposure to Airborne Particles during Hair Bleaching.

Respiratory symptoms among hairdressers are often ascribed to the use of bleaching powders that contain persulfate salts. Such salts can act as allergens and airway irritants but the mechanisms behind the negative health effects are not fully known. In order to understand why some hairdressers experience respiratory symptoms during, and after, sessions of hair bleaching, it is of importance to cha

Risk of coronary heart disease in patients with cancer: A nationwide follow-up study from Sweden.

BACKGROUND: Risk of coronary heart disease (CHD) in cancer patients has not been thoroughly investigated. The aim of the present study was to examine whether there is an association between cancer and first hospitalisation for CHD. METHODS: All individuals in Sweden with a diagnosis of cancer between 1st January 1987 and 31st December 2008 were followed for first hospitalisation for CHD. The refer

Decreased expression of genes involved in oxidative phosphorylation in human pancreatic islets from patients with type 2 diabetes.

OBJECTIVE: Gene expression alterations, especially in target tissues of insulin, have been associated with type 2 diabetes (T2D). Here, we examined if genes involved in oxidative phosphorylation (OXPHOS) show differential gene expression and DNA methylation in pancreatic islets from patients with T2D compared with non-diabetic donors. DESIGN AND METHODS: Gene expression was analyzed in human panc

Latitudinal differences in long-term migratory change in the willow warbler (Phylloscopus trochilus)

Location is everything and the geographical distribution of populations will make them differentially affected by global warming. Sweden’s north to south orientation presents a great frame for studying the effect of latitudinal climate change. We present a long-term study on the migratory behaviour of two populations of Willow Warbler subspecies (southern Phylloscopus trochilus trochilus and north

Integrating Ground Source Heat Pumps into Elderly Homes as Energy-efficient Heating and Cooling Solution - A Swedish Case Study

Energy efficiency and environmental questions have gained increased attention over the last decade. In combination with global warming and increasing cooling demands, the Swedish market for combined heating and cooling solutions such as ground source heat pumps expands. As it currently stands, the multi-family building market is highly dominated by district heating, while the market share of combi

Popularvetenskapliga artiklar

Microsoft Word - Populärvetenskapliga artiklar Populärvetenskapliga artiklar av relevans för SAPES 2010-2012 Andersson, G. 2010. Dyrare mat – vem tjänar på det? Newsmill.  Andersson, G. 2010. Trafikverket är inkonsekvent om mångfald i vägkanter. Newsmill.  Andersson, G. 2011. Vi måste betala mer för miljö och sociala rättigheter. Miljöaktuellt.  Bengtsson J., Smith H.G. & Öborn I. 2011. Mångfald i

https://www.cec.lu.se/sites/cec.lu.se/files/popularvetenskapliga_artiklar.pdf - 2026-06-08

10042016 679 51 mp46 lernmarkb j diab res 2015

2720650.dvi Research Article Participant Experiences in the Environmental Determinants of Diabetes in the Young Study: Common Reasons for Withdrawing Barbro Lernmark,1 Kristian Lynch,2 Judith Baxter,3,4 Roswith Roth,5 Tuula Simell,6 Laura Smith,2 Ulrica Swartling,1 Suzanne Bennett Johnson,7 and TEDDY Study Group1,2,3,5,6,8,9 1Department of Clinical Sciences, Lund University, CRC, Jan Waldenströms

https://www.teddy.lu.se/sites/teddy.lu.se/files/10042016_679_51_mp46_lernmarkb_j_diab_res_2015.pdf - 2026-06-08

Impact of collegial midwifery assistance during second stage of labour on women’s experience : a follow-up from the Swedish Oneplus randomised controlled trial

Objective To compare experiences of the second stage of labour in women randomised to assistance by one or by two midwives to reduce severe perineal trauma (SPT). Design Analysis of a secondary outcome within the Swedish Oneplus multicentre randomised trial. Setting Five obstetric units in Sweden between December 2018 and March 2020. Participants Inclusion criteria in the Oneplus trial were women

Global Cell-ID Positioning Using Artificial Neural Networks

Den som har använt GPS under en längre tid med en äldre telefon eller en smart klocka har antagligen märkt att batteriet snabbt tar slut. GPS har dessutom sämre precision om du är inomhus eller i en större stad med höga byggnader. I detta examensarbete så undersöks en alternativ teknik för utomhuspositionering som är mer batterivänlig än GPS. GPS har länge dominerat inom positionering på grund avFor many years, outdoor localization has been dominated by Global Positioning System (GPS) and other GNSS-based methods. While GPS provides global coverage and usually high accuracy, it has its limitations. GPS has lower accuracy in areas with many obstructions, such as buildings or trees, and is power consuming compared to other localization methods. Therefore, GPS may not be the best localizatio

Swedish Climate Symposium 2026

20 maj 2026 11:00 till 22 maj 2026 15:00 | Konferens We’re excited to announce that the third Swedish Climate Symposium will take place 20–22 May 2026, hosted this time in Lund under the theme “Climate Research: Science, Society, Actions”. This symposium brings together researchers, policymakers, and stakeholders from across Sweden to deepen our understanding of climate change and explore pathways

https://www.lu.se/evenemang/swedish-climate-symposium-2026 - 2026-06-08

Publication In EMBO Journal

Activation of endogenous retroviruses during brain development causes an inflammatory response Article Activation of endogenous retroviruses during brain development causes an inflammatory response Marie E Jönsson1 , Raquel Garza1 , Yogita Sharma1, Rebecca Petri1 , Erik Södersten2, Jenny G Johansson1, Pia A Johansson1 , Diahann AM Atacho1, Karolina Pircs1 , Sofia Madsen1, David Yudovich3, Ramprasa

https://www.molecular-neurogenetics.lu.se/sites/molecular-neurogenetics.lu.se/files/2021-03/publication%20in%20EMBO%20journal.pdf - 2026-06-08