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https://www.lusem.lu.se/calendar/ekh-seminar-lusah-rhiannon-stephens - 2026-06-04

Background: We have previously identified a locus on human chromosome 20q13.1, encompassing related genes of postulated WFDC-type protease inhibitors and semen coagulum proteins. Three of the genes with WFDC motif also coded for the Kunitz-type protease inhibitor motif. In this report, we have reinvestigated the locus for homologous genes encoding Kunitz motif only. The identified genes have been

Due to the consistently high proportion of surgical site infections (SSI) after vascular surgery, a change of prophylactic antibiotic therapy from cloxacillin/cefotaxime to trimethoprim/sulfamethoxazole (TMP-SMX) was conducted in 2016. The study included consecutive patients undergoing lower extremity revascularization due to acute or chronic lower extremity arterial disease. The antibiotic regime

BACKGROUND: The changes of cancer incidence upon immigration can be used as an estimator of environmental influence on cancer risk. We studied site-specific liver and biliary cancers in first-generation immigrants to Sweden with an aim to search for aetiological clues and to find evidence for indigenous incidence rates. MATERIAL AND METHODS: We used the nation-wide Swedish Family-Cancer Database t

PURPOSEAPR-246 (PRIMA-1MET) is a novel drug that restores transcriptional activity of unfolded wild-type or mutant p53. The main aims of this first-in-human trial were to determine maximum-tolerated dose (MTD), safety, dose-limiting toxicities (DLTs), and pharmacokinetics (PK) of APR-246. PATIENTS AND METHODSAPR-246 was administered as a 2-hour intravenous infusion once per day for 4 consecutive d

Intracerebral transplantation of porcine embryonic dopamine-producing neurons has been suggested as a method to treat patients with Parkinson's disease. Even though the brain is an immunologically privileged site, neuronal xenografts are usually rejected within a few weeks. T cells are important for this process, but the exact cellular events leading to rejection are poorly characterized. Brain ce

The genetic causes of familial breast cancer are still unclear, where only less than 20% have evident germline mutations. Most studies focus on mutations that cause a direct impact in the protein, disregarding the synonymous variants, where the codon is changed but the amino acid encoded remains the same. Synonymous variants can affect mRNA stability and translation, by differences in codon usage

Background Medication abortion, with a combination of mifepristone and misoprostol, is highly effective and safe. However, there is insufficient evidence on efficacy and safety at very early gestations before a pregnancy can be visualized with ultrasonography. Methods We conducted a multicenter, noninferiority, randomized, controlled trial involving women requesting medication abortion at up to 42

Mitochondrial dysfunction is associated with pathogenic mitochondrial (mt)DNA mutations. The majority of mtDNA point mutations have a heteroplasmic status, which is defined as the coexistence of wild-type and mutated DNA within a cell or tissue. Previous findings demonstrated that certain mtDNA heteroplasmic mutations contribute to widely spread chronic diseases, including cancer, and alterations

https://www.khm.lu.se/sites/khm.lu.se/files/2025-01/KONA31%20Det%20mest%20sorgliga%20%C3%A4r%20att%20jag%20var%20tvungen%20att%20anv%C3%A4nda%20ord.pdf - 2026-06-04

Objectives: To investigate absolute and relative risk of serious infections in adult/elderly inflammatory bowel disease (IBD) diagnosed 2002–2017. Methods: Nationwide, register-based cohort study of Swedish patients with IBD compared with general population matched reference individuals with regard to time to first serious infection, equal to hospital admission. Multivariable Cox regression estima

Objectives To assess the association between neonatal BCG vaccination and mortality between 28 days and 3 years of age among tuberculosis (TB)-exposed and TB-unexposed children. Design Prospective cohort study. Setting Bandim Health Project runs an urban Health and Demographic Surveillance site in Guinea-Bissau with registration of mortality, vaccination status and TB cases. Participants Children

Introduction: It is unclear if antibiotic prophylaxis reduces the risk of surgical site infection (SSI) in thyroid surgery. This study assessed risk factors for SSI and antibiotic prophylaxis in subgroups of patients. Method and design: A nested case–control study on patients registered in the Swedish National Register for Endocrine Surgery was performed. Patients with SSI were matched 1:1 by age

Head and neck skin cancer surgery using a full thickness skin graft is a common procedure. Evidence concerning the effects of perioperative antithrombotic treatment on complications is limited. The aim of this study was to evaluate whether perioperative antithrombotic treatment is associated with risk of necrosis, bleeding or infection after full thickness skin graft surgery. Retrospective single-

MVEN17 Samhällsplanering med klimatperspektiv VT2018 Kurstid: 15 januari - 19 mars 2018 Kursansvarig: Johanna Alkan Olsson johanna.alkan_olsson@cec.lu.se Lärare LU: Helena Hanson Helena.hanson@cec.lu.se Nora Smedby nora.smedby@iiiee.lu.se Maria Johanson maria.johansson@arkitektur.lth.se Litteratur: Enligt separat lista Studieteknik: Läs om studieverkstaden Studenträttigheter: Läs om dina rättighet

https://www.cec.lu.se/sv/sites/cec.lu.se.sv/files/vt18_mven17_schema.pdf - 2026-06-04

My Child Is Islet Autoantibody Positive: Impact on Parental Anxiety My Child Is Islet Autoantibody Positive: Impact on Parental Anxiety https://doi.org/10.2337/dc17-0166 OBJECTIVE To assess parent anxiety in response to genetic and islet autoantibody (IA) testing in children at increased genetic risk for type 1 diabetes followed from birth in The Environmental Determinants of Diabetes in the Young

https://www.teddy.lu.se/sites/teddy.lu.se/files/2021-11/72%2010262018_679_72_MP64_Johnson_Diab%20Care_2017.pdf - 2026-06-04

https://www.ht.lu.se/en/the-faculties/whats-on/calendar/event/invisible-nation-screening-film-followed-panel-discussion/ - 2026-05-25

https://www.ht.lu.se/om-fakulteterna/aktuellt/kalendarium/evenemang/invisible-nation-screening-film-followed-panel-discussion/ - 2026-05-25