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The human DUSP15 gene encodes an uncharacterized 235-amino acid member of the subfamily of small dual specificity protein phosphatases related to the Vaccinia virus VH1 phosphatase. Similar to VHR-related MKPX (VHX) (DUSP22), the predicted protein has an N-terminal myristoylation recognition sequence, and we show here that both are indeed modified by the attachment of a myristate to Gly-2. In reco
To study the biochemistry of processing of a soluble protein Ag by an APC, we investigated how 125 I-labeled human insulin (HI) is processed in situ by TA3 mouse hybridoma B cells. Fractionation of TA3 cells into their extracellular, plasma membrane-associated and intracellular compartments coupled with the use of HPLC enabled us to analyze several peptides derived from each compartment. One HI
Introduction Receiving Bacille Calmette-Guérin (BCG)-Denmark vaccine at birth has been associated with ∼40% reductions in all-cause neonatal mortality. We evaluated determinants of BCG skin reaction characteristics by age 2 months and tested the association with subsequent mortality. Methods Prospective observational study amalgamating five trials providing BCG-at-birth that were conducted between
Accidents nearby work zones are a persistent road safety problem in many European countries. The Conference of European Directors of Roads (CEDR) has initiated and finances the IRIS project (Incursion Reduction to Increase Safety in road work zones) with the aim to collect and share information about best practices in temporary traffic management at road works. An analysis of work zone accidents aAccidents nearby work zones are a persistent road safety problem in many European countries. The Conference of European Directors of Roads (CEDR) has initiated and finances the IRIS project (Incursion Reduction to Increase Safety in road work zones) with the aim to collect and share information about best practices in temporary traffic management at road works. An analysis of work zone accidents a
The most complete and realistic physiological data are derived from direct measurements during human experiments; however, they present some limitations such as ethical concerns, time and cost burden. Thermophysiological models are able to predict human thermal response in a wide range of environmental conditions, but their use is limited due to lack of validation. The aim of this work was to vali
2,4,6-Trinitrotoluene (TNT) is the major explosive in ammunition dumped into lakes and the sea after World War II. To identify useful biomarkers of TNT-exposure for forthcoming fish monitoring studies at ammunition dumping sites, rainbow trout (Oncorhynchus mykiss) were intraperitoneal (i.p.) injected with TNT in peanut oil at doses of 0, 100, 200 or 400 mg TNT/kg body weight and sampled 72 h late
A polymorphism consisting of a deletion near the 5' splice site of exon 18 on the alpha2-macroglobulin (A2M) gene (A2M-2) has been suggested to be associated with Alzheimer's disease (AD) in family-based studies. We studied the A2M-2 allele together with the ApoE alleles in a large series on patients with AD (n = 449) and age-matched controls (n = 349). Neuropathologically confirmed diagnoses were
The objectives of the present study were to estimate 10-year probabilities of clinical vertebral fractures in women, according to age and bone mineral assessment using phalangeal quantitative ultrasound (QUS). Risks were computed from UK derived data on the incidence of a first symptomatic vertebral fracture and mortality rates for each year of age using Poisson models. The 10-year probability of
European CH4 and N2O emissions are estimated for 2006 and 2007 using four independent inverse modelling systems, based on different global and regional Eulerian and Lagrangian transport models. This ensemble approach is designed to provide more realistic estimates of the overall uncertainties in the derived emissions, which is particularly important for verifying bottom-up emission inventories. We
We used two theoretical methods to estimate reduction potentials and acidity constants in Mn superoxide dismutase (MnSOD), namely combined quantum mechanical and molecular mechanics (QM/MM) thermodynamic cycle perturbation (QTCP) and the QM/MM-PBSA approach. In the latter, QM/MM energies are combined with continuum solvation energies calculated by solving the Poisson-Boltzmann equation (PB) or by
Lipoprotein(a) [Lp(a)], a strong independent cardiovascular risk factor, consists of the unique apolipoprotein(a) [apo(a)] covalently linked to a low-density lipoprotein particle. Apo(a) contains a widely differing number of the plasminogen-like kringle IV, a size polymorphism that is codominantly inherited. In addition to powerful genetic control, renal failure is known to influence the plasma Lp
Systemic lupus erythematosus (SLE, OMIM 152700) is a complex autoimmune disease that affects 0.05% of the Western population, predominantly women(1-4). A number of susceptibility loci for SLE have been suggested in different populations, but the nature of the susceptibility genes and mutations is yet to be identified(5-9). We previously reported a susceptibility locus (SLEB2) for Nordic multi-case
Systolic tissue Doppler measurements (s') have been used to measure the velocity in myocardial motion and are a valuable tool for evaluating the systolic function of the left and right ventricles. Digestion of food is known to significantly alter hemodynamics and may therefore affect s'. The effect of food intake on s' parameters has not yet been studied. We assessed whether s' is affected by food
Great Spotted and Syrian Woodpeckers (Dendrocopos major and D. syriacus) are known to hybridize in nature; however, the extent of this phenomenon is not known due to difficulties in hybrid detection based on plumage analyses. Here, we tested five markers (one mitochondrial and four nuclear) and a set of six microsatellite loci for the identification of these two Woodpeckers and their hybrids. Sequ
The Italian Sarcoma Group and the Scandinavian Sarcoma Group designed a joint study to improve the prognosis for patients with Ewing's family tumors and synchronous metastatic disease limited to the lungs, or the pleura, or a single bone. The study was opened in 1999 and closed to the enrollment in 2008. The program consisted of intensive five-drug combination chemotherapy, surgery and/or radiothe
Modeller som beskriver a¨mnesyntesen i stja¨rnor och supernovor har haft begra¨nsad framg˚ang med att f¨orklara de observerade halterna i stja¨rnor. Dessa modeller a¨r inkonsekventa f¨or olika grund¨amnen och det saknas en komplett bild o¨ver den a¨mnesberikningen som sker i v˚art universum. Syntes av ¨amnen i stj¨arnor beror p˚a m˚anga faktorer som ursprunglig kemiska sam- mansa¨ttning hos stja¨rIn this work we study the spectra of 423 stars in the Milky Way disk in order to determine their zinc abundances. The methodology to determine elemental abundances consists of synthesising sets of spectra with varying zinc abundances and comparing them with the observed spectra to find the best fit. The aim of the project was to compare the spectra syn- thesis method used here to Bensby et al. (2014
Microsoft Word - COSM38_literature_2021.docx COSM38: Religion and Society in East and Southeast Asia, 7,5 credits Literature list, fall semester 2021 Course literature: Abrahms-Kavunenko, Saskia. 2019. "Introduction." In Enlightenment and the Gasping City: Mongolian Buddhism at a Time of Environmental Disarray, 1-23. Ithaca; London: Cornell University Press. 23 pages Abrahms-Kavunenko, Saskia. 201
https://www.ace.lu.se/sites/ace.lu.se/files/2021-09/COSM38_literature_2021.pdf - 2026-05-29
Ett nytt instrument för detektion av tidiga tecken på utmattningssyndrom: validering av Lund University Checklist for Incipient Exhaustion (LUCIE) Bakgrund Stressrelaterad ohälsa (t.ex. arbetsrelaterat utmattningssyndrom; UMS) är ett samhällsproblem i många postindustriella länder. Erfarenheten visar att tidig upptäckt och intervention är avgörande för att hindra långsiktiga negativa konsekvenser
ASG 2025-2026 How do we shape higher education for a world driven by computational methods? As computational science becomes essential across disciplines, we need to rethink how we design, structure, and support education in this rapidly evolving interdisciplinary field. Computational science is an exciting, interdisciplinary field that uses advanced computational methods to solve big research cha
https://www.pi.lu.se/en/advanced-study-groups-enny/computational-science-curricula - 2026-05-27
