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Lipid nanoparticles of reversed internal phase structures, such as cubic micellar (I2) structure show good drug loading ability of peptides and proteins as well as some small molecules. Due to their controllable small size and inner morphology, such nanoparticles are suitable for drug delivery using several different administration routes, including intravenous, intramuscular and subcutaneous inje

Sedan 1990-talet har Sverige ett dualt skattesystem, vilket innebär att inkomst av tjänst och kapital beskattas utifrån olika skattesatser, sistnämnda betydligt lägre. Denna ordning skapar incitament till att hänföra inkomster till inkomstslaget kapital. Uppsatsen syftar delvis till att belysa de teoretiska skillnaderna inkomstslagen emellan, då det är en intressant fråga i sig som dessutom är nödSince the 1990s, Sweden has had a dual tax system, in the sense that income of employment and income of capital are taxed differently, the latter considerably lower. This order creates incentives to attribute the income to the one of capital. This thesis aims to highlight the theoretical differences between income of capital and employment, whereas it is an interesting question in itself, but also

Actors in the Swedish building industry have shown interest to build tall buildings in Sweden. It has historically been very few high rises and skyscrapers built and therefore the experience and traditions of high rise buildings are limited in Sweden. The aim of this thesis was to collect and present experiences from high-rise buildings, both from national and international high rise projects

Densiteten I stadens utveckling utmanar oss arkitekter till att skapa bra arkitektur i stadsrummet. Staden växer och skapar nya förutsättningar i människans vardag. Staden förtätas och då brist på bra centralt placerad mark blir väldigt påfrestande så skapas nya urbana typologier. Jag vill i mitt examensarbete arbeta vidare på denna problematik och undersöka mer specifikt, hur ser bostaden ut i

Objectives To develop a score for assessment of patients' symptoms in primary Sjogren's syndrome (SS): the EULAR SS Patient Reported Index (ESSPRI). Methods Dryness, pain, somatic and mental fatigue were identified as the main symptoms of patients with primary SS, in studies developing the Profile of Fatigue and Discomfort (PROFAD) and Sicca Symptoms Inventory (SSI). It was suspected that a single

To meet future challenges in urban development with denser housing and sustainable water resources, society needs to take actions. Densification of housing is met by expanding housing into old industrial areas often contaminated and water resources are already affected in some areas by over exploiting, pollutants spreading and a changing climate leading to changes in recharge.Growing concerns are

There is no alternative! Margaret Thatcher once proclaimed in order to defend neoliberalist reforms and – implicitly – the capitalist regime. But if one doesn’t agree with Thatcher’s definition of the situation and her (and her many followers’) subsequent analysis, what viable options does one really have? Is it possible to come up with an empirically grounded alternative to the dominant modes of

We investigate the potential of different pre-fetching and/or caching strategies for different user behaviour with respect to surfing or browsing in a catch-up-TV network. To this end we identify accounts and channels associated with strong or weak surfing or browsing respectively and study the distributions of hold times for the different types of behaviour. Finally we present results from a requ

Although a large volume of work has been conducted regarding tourism industries across the world, the dominant analysis in the geographies of tourism tends to draw upon post-modern discourse analysis and representational theories. This has resulted in calls to develop more materialist analyses of tourism landscapes. Using the case study of Long Bay, a small coastal settlement in Portland parish, J

Background: The spread of SARS-CoV-2, originating in Wuhan, China, was classified as a pandemic by the World Health Organization on March 11, 2020. The governments of affected countries have implemented various measures to limit the spread of the virus. The starting point of this paper is the different government approaches, in terms of promulgating new legislative regulations to limit the virus d

Denna avhandling undersöker vetenskapens roll i den politiska processens tidiga stadier. Detta görs genom att studera hur "geoengineering" kommer upp på den politiska agendan. Begreppet ”geoengineering” används även på svenska och beskriver en uppsättning idéer om hur man stabiliserar den globala temperaturen genom att ingripa i jordens miljösystem. Begreppet mötte stark skepsis i det vetenskapligThis thesis examines the role of science in the earliest stages of the political process. It does this by studying the emergence of ‘geoengineering’ on the political agenda. The term describes a set of ideas on how to stabilize global temperature by intervening into the Earth’s natural systems, and was subject to a strong taboo in the scientific community until the mid-2000s. Yet within a decade,

A novel method for the preparation of molecularly imprinted microspheres has been developed. Theophylline, caffeine, and 17β-estradiol are used as template molecules to demonstrate the generally applicable methodology. In the presence of a template molecule, cross-linking polymerization starting from a dilute solution of methacrylic acid and trimethylolpropane trimethacrylate yields polymer micros

The difference in arsenic concentration and speciation between benthic (Pteromylaeus bovinus, Myliobatis aquila) and pelagic rays (Pteroplatytrygon violacea) from the northern Adriatic Sea (Gulf of Trieste) in relation to their size (age) was investigated. High arsenic concentrations were found in both groups with tendency of more efficient arsenic accumulation in benthic species, particularly in

We investigate the adaption of the recently developed exponential integrators called EPIRK in the so-called domain-based implicit-explicit (IMEX) setting of spatially discretized PDE's. The EPIRK schemes were shown to be efficient for sufficiently stiff problems and offer high precision and good stability properties like A- and L-stability in theory. In practice, however, we can show that these st

This work is part of a research project studying the learning of fine motor skills in rats. A system for tracking a rat paw using a system of high-speed cameras is presented along with preliminary analysis of the correlation between paw movement and neural data. The tracking method is generative, modeling the rat paw as a set of linked ellipsoids. To find the most probable paw pose a number of hyp

Sweden is renowned for its centralised wage bargaining system, which has been studied from the point of view of inflation, wage differentials and unemployment. This article studies media coverage of wage bargaining rounds in the 1950s–1960s and in the 2000s–2010s to investigate the social understanding of what the wage bargaining institutions are supposed to do. The results indicate that the opera

In many applications, such as remote sensing or wave slamming on ships and offshore structures, it is important to have a good model for wave slope. Today, most models are based on the assumption that the sea surface is well described by a Gaussian random field. However, since the Gaussian model does not capture several important features of real ocean waves, e.g. the asymmetry of crests and troug

While the themes of fragmentation and insufficient coherence dominated discussions in the field of media and communication studies a decade ago, today they seem less urgent, even if at times still problematic. In terms of theory, the field is well served by its permeable boundaries, since much of its theory is 'imported'. Moreover, theory needs nondoctrinaire critical stances to address the distre

We report extensive relativistic multiconfiguration Dirac-Hartree-Fock calculations of oscillator strengths and hyperfine structures for a large number of electric dipole transitions in In II. Results for the 5s(21)S(0)-5s5p P-3(0)o hyperfine induced transition are also presented. Core polarization is accounted for by means of explicit CI. To describe spin-polarization effects configuration state