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OBJECTIVE: To investigate the possible role of FCGR2A 519A>G and FCGR3A 559A>C functional polymorphisms in the genetic predisposition to susceptibility to systemic sclerosis (SSc) or clinical phenotype. METHODS: A total of 1566 patients with SSc and 2271 geographically matched controls were included in our study. We analyzed the genotype and allele frequencies of the FCGR2A 519A>G and FCGR3A 559A>

In a previous study we presented data indicating that the expanded population of CD4(-)CD8(-) (DN) alphabeta T cells in TCRalpha-chain-transgenic mice was partially if not entirely derived from gammadelta T cell lineage cells. The development of both gammadelta T cells and DN alphabeta T cells is poorly understood; therefore, we thought it would be important to identify the immediate precursors of

The immune processes associated with atherogenesis have received considerable attention during recent years. IgG FcRs (FcgammaR) are involved in activating the immune system and in maintaining peripheral tolerance. However, the role of the inhibitory IgG receptor FcgammaRIIB in atherosclerosis has not been defined. Bone marrow cells from FcgammaRIIB-deficient mice and C57BL/6 control mice were tra

Immunoglobulin G (IgG) glycosylation modulates antibody activity and represents a major source of heterogeneity within antibody preparations. Depending on their glycosylation pattern, individual IgG glycovariants present in recombinant antibody preparations may trigger effects ranging from enhanced pro-inflammatory activity to increased anti-inflammatory activity. In contrast, reduction of IgG gly

Current hemophilia B treatment guidelines recommend routine prophylaxis with factor IX (FIX) replacement products, tailored to maintain plasma activity at levels that will prevent bleeds. However, plasma FIX activity may not be the primary determinant or best indicator of hemostatic efficacy due to its extravascular distribution. FIX replacement therapy has evolved to include extended half-life (E

Context. Wide hot subdwarf B (sdB) binaries with main-sequence companions are outcomes of stable mass transfer from evolved red giants. The orbits of these binaries show a strong correlation between their orbital periods and mass ratios. The origins of this correlation have, so far, been lacking a conclusive explanation. Aims. We aim to find a binary evolution model which can explain the observed

This thesis comprises three different topics within the field of tribology. First, design functions for analyses of slider bearings are developed. Second, a lubricant model applied to elastohydrodynamically lubricated (EHL) line contacts considering wall-slip is presented. Finally, an experimental apparatus for investigations of lubricants at high pressures is presented. The design of hydrodynami

To update the European System for Cardiac Operative Risk Evaluation (EuroSCORE) risk model. A dedicated website collected prospective risk and outcome data on 22 381 consecutive patients undergoing major cardiac surgery in 154 hospitals in 43 countries over a 12-week period (May-July 2010). Completeness and accuracy were validated during data collection using mandatory field entry, error and range

The Sahel belt of Africa has been the focus of intensive scientific research since the 1960s, spurred on by the chronic vulnerability of its population to recurring drought and the threat of long-term land degradation. But satellite sensors have recently shown that much of the region has experienced significant increases in photosynthetic activity since the early 1980s, thus re-energizing long-sta

IntroductionPaper I: An Artificial Neural Network (ANN) was constructed to identify ST Elevation Myocardial Infarction (STEMI) and predict the need for Percutaneous Coronary Intervention (PCI). Paper II, III and IV: Studies suggest that O2 therapy may be harmful in STEMI patients. We therefore conducted the SOCCER study to evaluate the effects of O2 therapy in STEMI patients.MethodsPaper I: 560 am

OBJECTIVES: To calculate a polygenic risk score (PRS) based on single nucleotide variants (SNVs) previously associated with primary Sjögren's disease (SjD) with genome-wide significance, and determine the genetic risk for SjD stratified by antibodies, sex and age at diagnosis.METHODS: Patients with SjD (n = 1065) were genotyped using Illumina OmniExpressExome chip. Control genotype data were avail

I Sverige avlider över tusen personer varje år till följd av en fallskada och cirka 70 000 personer skadas såpass allvarligt att de behöver vård. Fallolyckor kostar Sverige 11.1 miljarder kronor per år och är en av de största utmaningarna för sjukvården och äldreomsorgen idag. Då risken att råka ut för en fallskada ökar med ålder samt att en stor del av befolkningen i Sverige beräknas nå pensionsåMore than a thousand people die each year in Sweden due to fall injuries and approximately 70,000 people injures themselves so seriously that they need care. Falling accidents cost Sweden 11.1 billion SEK a year and is one of the biggest challenges for healthcare and elderly care today. Since the risk of fall injuries increase with age and a large part of the population in Sweden is expected to re

The high small-scale diversity of plant species in semi-natural grasslands can be seen as a function of environmental conditions and land use history. This study explores the potential of using Worldview-2 spectral imagery and accessible GIS data to identify a set of vegetation characteristics known to influence biodiversity in semi-natural grasslands. Field sampling was done in 52 grassland sites

Biodiversity, and in particular plant species diversity decline is linked to landscape fragmentation and habitats loss due to land use transformations but also to decreasing dispersal vectors in the landscape. During the last 200 years the landscape has undergone dramatic changes in its structure and its habitats diversity. Among the different habitats that constitute rural landscape there are thr

Akut hjärtsjukdom, som bland annat innefattar hjärtinfarkt och vissa typer av kärlkramp, utgör idag en ledande orsak till lidande och död i världen. På svenska akutmottagningar söker varje år cirka 180 000 patienter för bröstsmärta, vilket kan vara ett symtom på någon av ovanstående sjukdomar. För att snabbt komma fram till rätt diagnos ska ansvarig läkare väga samman patientens sjukdomshistoria, Introduction: There is a need for risk stratification of emergency department (ED) chest pain patients. The Global Registry of Acute Coronary Events risk score (GRACE RS) predicts adverse events in patients with confirmed acute coronary syndrome (ACS), and has been validated on unselected ED patients with chest pain. Clinical gestalt is the unstructured overall clinical assessment, based on the ph