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Background Recent decades have witnessed tangible improvements in childhood cancer survival. However, the prognosis for children with congenital heart disease (CHD), the most prevalent birth defect, remains unclear. Due to improved survival of CHD and childhood cancer, evaluating outcomes within this intersection is important for clinical practice. We aimed to assess mortality post-cancer diagnosi

Introduction: Mycobacteria have a unique hydrophobic membrane with several lipid-enriched layers that are low in permeability, setting them apart from other bacteria. This complex structure, consisting of three distinct layers is crucial for cell growth, virulence, and providing a barrier to antibiotics. Previously, we identified a plectasin variant, NZX, which showed activity against Mycobacteriu

BackgroundTo enable immunotherapy for ovarian cancers, precision targets for immune priming as well as patient stratification approaches are required. The tumor microenvironment in particularly the rare subtypes of low-grade serous, mucinous, clear cell and endometrioid ovarian cancer, remains poorly characterized, and these tumors have been largely ignored in the immuno-oncology setting.MethodsWe

Background: Involving librarians as team members can lead to better quality in reviews. To improve their search results, an international diabetes project involved two medical librarians in a large-scale project planning of a series of systematic reviews for clinical guidelines in diabetes precision medicine. Case Presentation: The precision diabetes project was divided into teams. Four diabetes m

ADF/cofilins (AC) are essential F- and G-actin binding proteins that modulate microfilament turnover. The genome of Plasmodium falciparum, the parasite causing malaria, contains two members of the AC family. Interestingly, P. falciparum ADF1 lacks the F-actin binding residues of the AC consensus. Reverse genetics in the rodent malaria model system suggest that ADF1 performs vital functions during

Background: Affectivity has been suggested as a complex adaptive meta-system composed of positive affect and negative affect, two independent but interrelated markers of well-being, that can be represented as four distinct affective profiles: self-fulfilling (high positive affect/low negative affect), high affective (high positive affect/high negative affect), low affective (low positive affect/lo

Infectious diseases in farm animals triggered by pathogenic microorganisms affect the health and well-being of livestock and human populations. Pathogen detection is an important step for the successful diagnosis, treatment and control of infectious diseases in animals. Pathogens that persist in the poultry and livestock industries can be responsible for more than 70% of emerging infections. Thus,

The gut and oral microbiome is altered in people living with HIV (PLWH). While antiretroviral treatment (ART) is pivotal in restoring immune function in PLWH, several studies have identified an association between specific antiretrovirals, particularly integrase inhibitors (INSTI), and weight gain. In our study, we explored the differences in the oral and gut microbiota of PLWH under different ART

Moraxello catorrhalis is an emerging pathogen and all isolates are now considered beta-lactamase producing. Potential further use of vaccines against Streptococcus pneumoniae and nontypeable Haemophilus influenzae means that M. catarrhalis might be thrust further into the limelight. However, a vaccine has not yet been designed. In this review, the progress of M. catarrhalis adhesins as vaccine can

Nanoparticles present enormous surface areas and are found to enhance the rate of protein fibrillation by decreasing the lag time for nucleation. Protein fibrillation is involved in many human diseases, including Alzheimer's, Creutzfeld-Jacob disease, and dialysis-related amyloidosis. Fibril formation occurs by nucleation-dependent kinetics, wherein formation of a critical nucleus is the key rate-

BACKGROUND: Human glandular kallikrein 2 (hK2) and prostate-specific antigen (PSA) are members of an extensive kallikrein family of proteases. Both proteases are secreted as zymogens or proenzymes containing a seven amino acid propeptide that must be proteolytically removed for enzymatic activation. The physiological proteases that activate pro-hK2 and pro-PSA are not known. METHODS: The pro-hK2 p

Objective To investigate the effect of high dose vitamin A supplementation given with BCG vaccine at birth in an African setting with high infant mortality. Design Randomised placebo controlled trial. Setting Bandim Health Project's demographic surveillance system in Guinea-Bissau, covering approximately 90 000 inhabitants. Participants 4345 infants due to receive BCG. Intervention Infants were ra

We have recently reported that the inner layers of the arteries, the intima-media complex, of common carotid artery, move as much in the longitudinal direction as in the radial direction, during the cardiac cycle. In order to study this phenomenon we have developed a high-resolution ultrasonic method that can simultaneously record both the longitudinal and the radial movements of the arterial wall

We used three animal models of rats for rheumatoid arthritis (RA) in this study. Firstly, We found that CXI induced arthritis (CXIIA) is associated with the RT1 f haplotype and follows a chronic disease course affecting peripheral joints with both progression and relapses. The main difference of pathological changes in CXIIA rats against rats with CIIIA was a larger number of infiltrating lymphocy

Human pigmentation is a complex phenomenon commonly believed to serve a photoprotective function through the generation and strategic localization of black insoluble eumelanin biopolymers in sun exposed areas of the body. Despite compelling biomedical relevance to skin cancer and melanoma, eumelanin photoprotection is still an enigma: What makes this pigment so efficient in dissipating the excess

Molecular profiles of asynchronous breast cancer metastases are of clinical relevance to individual patients' treatment, whereas the role of profiles in synchronous lymph node metastases is not defined. The present study aimed to assess individual biomarkers and molecular subtypes according to the St Gallen classification in primary breast tumours, synchronous lymph node metastases and asynchronou