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Popular Abstract in Swedish Defekt mismatch-reparation och familjär cancerrisk Cancer är på cellnivå en genetisk sjukdom. Förändringar i cellens arvsmassa (DNA) drabbar tre huvudtyper av gener; onkgener, tumörsuppressorgener och DNA-reparationsgener. Onkgener är en grupp gener som befrämjar cellens tillväxt. Vid cancerutveckling aktiveras onkgener via mutation eller genom ökat uttryck, vilket ledInactivation of the DNA mismatch repair (MMR) system is a tumorigenic mechanism involved in 15-20% of tumor types such as colorectal and endometrial cancer and is specifically associated with the Hereditary Nonpolyposis Colorectal Cancer (HNPCC) syndrome. These MMR defective tumors are characterized by microsatellite instability (MSI), a phenomenon that reflects alterations in length of repeated s

The concept “Broken Technologies” is related to the question: “Which is the benefit of humanity studies?” Of course the question is rhetorical because, how could this question be answered if the benefit was not obvious? Any answer supposes that we understand what we are asking for and the study of “what we mean” is one of the axes of the epistemology of the humanities. Anyway, we can also put the

Psoriasis (Ps) and psoriasis arthritis (PsA) are poorly understood common diseases, induced by unknown environmental factors, affecting skin and articular joints. A single i.p. exposure to mannan from Saccharomyces cerevisiae induced an acute inflammation in inbred mouse strains resembling human Ps and PsA-like disease, whereas multiple injections induced a relapsing disease. Exacerbation of disea

Symptoms of infection and tissue pathology are caused by the host response; not by the microbe per se. The same response is also critical for the defence and is needed to clear infection. It is therefore essential to understand how the host response is activated and to identify the critical effector mechanisms of the defence. We have studied these issues in the urinary tract infection (UTI) model.

Uppsatsen utvärderar och undersöker effekterna av den svenska regleringen gällande särskilda transaktionsavtal, s.k. budrelaterade arrangemang. Detta genom att undersöka regleringens effekt på den svenska kapitalmarknaden och målbolagsaktieägare. Grunderna för den svenska takeoverregleringen presenteras genom att undersöka de relevanta bestämmelserna i, och förhållandet mellan, aktiemarknadsrätt, The thesis evaluates and examines the effects of the Swedish regulation of deal protection arrangements by looking to the impact of the provision on the Swedish capital market and target shareholders. The foundations of the Swedish takeover regulation are examined by presenting and arguing the relevant provisions in, and relationship between, stock exchange law, corporate law and EU law. Fiduciar

I den första svenska jämställdhetslagen från 1979 skyddades bara diskrimineringsgrunden kön. Redan då insåg lagstiftaren att det behövdes en bevislättnad eftersom diskriminering bygger på att man vet orsaken till att arbetsgivaren har handlat på ett visst sätt. Jämställdhetslagens bevisbörderegel skapades som en presumtionsregel. En presumtionsregel innebär att arbetstagaren ska bevisa vissa omstäIn the first equality act of Sweden from 1979, the scope of the discrimination protections afforded under the act were limited by the gender of a given party. Already at that time, the legislator saw a need for a relaxation of the burden of proof as previously, discrimination matters turned on the requirement that the claimant be cognizant of why the defendant had acted in a certain manner. The r

Popular Abstract in Swedish Standard-12-avlednings-EKG är fortfarande ett av de viktigaste och vanligaste redskapen för att diagnostisera hjärtsjukdom trots att ett flertal olika undersökningstekniker har utvecklats under åren. Vid standard-EKG används 10 elektroder, 6 på bröstkorgen och 4 distalt på armar och ben. Inom både industrin och akademin har många års arbete lagts ned på utveckling av deThe standard 12-lead electrocardiogram (ECG) remains one of the most important and most frequently used tools for diagnosing cardiac diseases, although several different examination modalities in cardio¬logy have been developed over the years. The standard ECG uses 10 electrodes placed on well-defined positions on the body, 6 on the torso and 4 distally on the limbs. Both industry and academia hav

"People and stories that really stick with you" - The Raoul Wallenberg Institute of Human Rights and Humanitarian Law Skip to content Search for: Search Button Home About Us Who We Are Our History About Raoul Wallenberg Our Theory of Change Staff Opportunities Annual Reports Whistleblower Our work What we do Multi-Disciplinary Research Higher Education Strategic Advice and Analysis Outreach Evalua

https://rwi.lu.se/2015/03/20/people-and-stories-that-really-stick-with-you/ - 2026-07-17

Rebecca Stern: Human Rights Are For Humans, Not Citizens - The Raoul Wallenberg Institute of Human Rights and Humanitarian Law Skip to content Search for: Search Button Home About Us Who We Are Our History About Raoul Wallenberg Our Theory of Change Staff Opportunities Annual Reports Whistleblower Our work What we do Multi-Disciplinary Research Higher Education Strategic Advice and Analysis Outrea

https://rwi.lu.se/news/rebecca-stern-human-rights-are-for-humans-not-citizens/ - 2026-07-17

Integrating Rights and Equality in Climate Change, Disasters, and Human Mobility: A Primer for Higher Education Institutions Integrating Rights and Equality in Climate Change, Disasters, and Human Mobility: A Primer for Higher Education Institutions Prepared by Graduate Legal Studies Institute, Ateneo de Manila University School of Law, for the Raoul Wallenberg Institute of Human Rights and Humani

https://rwi.lu.se/wp-content/uploads/2025/06/FINAL-20250207_Integrating-Rights-and-Equality_FA.pdf - 2026-07-17

Cortical arealization arises during neurodevelopment from the confluence of molecular gradients representing patterned expression of morphogens and transcription factors. However, whether similar gradients are maintained in the adult brain remains unknown. Here, we uncover three axes of topographic variation in gene expression in the adult human brain that specifically capture previously identifie

PURPOSE: Burkitt lymphoma (BL) has unique biology and clinical course but lacks a standardized prognostic model. We developed and validated a novel prognostic index specific for BL to aid risk stratification, interpretation of clinical trials, and targeted development of novel treatment approaches. METHODS: We derived the BL International Prognostic Index (BL-IPI) from a real-world data set of adu

Human malignant hematopoietic stem and progenitor cells (HSPCs) reside in bone marrow (BM) niches, which remain challenging to explore due to limited in vivo accessibility and constraints with humanized animal models. Several in vitro systems have been established to culture patient-derived HSPCs in specific microenvironments, but they do not fully recapitulate the complex features of native bone

Protein HC, a heterogeneously charged low molecular weight glycoprotein, and its IgA complex were isolated from human plasma and urine. Plasma from individuals with monoclonal IgA populations was used as starting material for the isolation of the protein HC-IgA complex to obtain homogeneous complex populations. Neither low molecular weight protein HC nor its IgA complex in the concentrations 30 an

Background: There are currently no methods in clinical use that can detect early systemic dissemination of urothelial tumor cells. Objective: To evaluate measurement of circulating tumor cells (CTCs) as a biomarker for disseminated disease in patients with advanced bladder cancer. Design, setting, and participants: Between March 2013 and October 2015, 88 patients were prospectively included in the

Although a causative role of α-synuclein (α-syn) is well established in Parkinson’s disease pathogenesis, available animal models of synucleinopathy do not replicate the full range of cellular and behavioral changes characteristic of the human disease. This study was designed to generate a more faithful model of Parkinson’s disease by injecting human α-syn fibril seeds into the rat substantia nigr

PURPOSE: To examine the cytokine profile of epithelial cells lining the human urinary tract with the aim of differentiating between the constitutive and disease-related cytokine production in these tissues.MATERIALS AND METHODS: Sections from the renal pelvis, ureter, bladder or urethra were obtained from 22 patients undergoing urinary tract surgery and were stained with monoclonal antibodies to i

BACKGROUND: To analyze the potential effect of social inequality on pancreatic cancer risk in Western Europe, by reassessing the association within the European Prospective Investigation into Cancer and Nutrition (EPIC) Study, including a larger number of cases and an extended follow-up.METHODS: Data on highest education attained were gathered for 459,170 participants (70% women) from 10 European

Members of the New Kinase Family 3 (NKF3), PEAK1/SgK269 and Pragmin/SgK223 pseudokinases, have emerged as important regulators of cell motility and cancer progression. Here, we demonstrate that C19orf35 (PEAK3), a newly identified member of the NKF3 family, is a kinase-like protein evolutionarily conserved across mammals and birds and a regulator of cell motility. In contrast to its family members