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To test whether the arrangement of fibre types in the human muscle (m. vastus lateralis) from clinically healthy and young males can be regarded as random, fascicles at different parts of the muscle and with different fibre type proportions were studied. The randomness of the arrangement of fibre types was assessed by the number of enclosed fibres in a fascicle and, on the basis of a model, tested
Helicobacter pylori has been proposed as a causative agent of gastric cancer. The aim of this study was to define serum antibodies response against different H. pylori antigens in patients with gastric cancer. Serum samples were collected from 115 Lithuanian patients with non-cardia gastric cancer and 110 age- and sex-matched controls without cancer. Heat-stable, low-molecular-mass, and outer memb
The human hormone-sensitive lipase (HSL) gene encodes a 786-aa polypeptide (85.5 kDa). It is composed of nine exons spanning approximately 11 kb, with exons 2-5 clustered in a 1.1-kb region. The putative catalytic site (Ser423) and a possible lipid-binding region in the C-terminal part are encoded by exons 6 and 9, respectively. Exon 8 encodes the phosphorylation site (Ser551) that controls cAMP-m
HAMLET is a protein-lipid complex that selectively kills tumor cells. In this thesis, we identified new mechanisms, whereby HAMLET initiates and executes tumor cell death. HAMLET targets several cellular compartments ranging from the plasma membrane to the nucleus. HAMLET rapidly binds to the plasma membrane of tumor cells and the resulting changes in membrane shape and lipid composition activate
Long-chain fatty acids (LCFAs) are internalized by receptor-mediated mechanisms or receptor-independent diffusion across cytoplasmic membranes and are utilized as nutrients, building blocks and signaling intermediates. Here we describe how the association of LCFAs to a partially unfolded, extracellular protein can alter the presentation to target cells and cellular effects. HAMLET (Human α-lactalb
Background Cancer is associated with an increased risk of thromboembolic diseases, but data on the association between prostate cancer and thromboembolic diseases are scarce. We investigated the risk of thromboembolic disease in men with prostate cancer who were receiving endocrine treatment, curative treatment, or surveillance. Methods We analysed data from PCBaSe Sweden, a database based on the
Antibody-based microarrays are among the new, rapidly emerging technologies within the field of proteomics that has the potential to evolve into a key proteomic research tool, providing novel means to perform early diagnostics, identify biomarkers and gain insights into disease biology. The aim of this thesis, based on five original papers, was to develop antibody microarrays based on human recom
Popular Abstract in Swedish Urinvägsinfektioner (UVI) är en av människans vanligaste bakteriella infektioner och drabbar både kvinnor och män. Kvinnor drabbas av UVI under hela sitt vuxna liv, medan UVI incidensen hos män ökar efter 40 – 50 års ålder pga. ökande problematik i urinvägarna med prostataförstoring, m.m. UVI orsakas av ett flertal olika bakteriearter, men tarmbakterien Escherichia coliUrinary tract infections (UTI) are among the most common human infections, and febrile UTI with bacteremia the most severe form. The relation between bacteria and host decides disease severity. The dominating uropathogen is Escherichia coli (E. coli). P fimbriae are the virulence factor of E. coli most clearly associated to severe disease. P fimbriated E. coli predominated in bacteremic febrile UT
Kraven på historisk rättvisa har intensifierats under de senaste decennierna. Sanningskommissioner, officiella ursäkter och ekonomiska ersättningar är nu vanliga sätt att bemöta människors vittnesmål om oförrätter i det förflutna. Tidigare forskning har fokuserat på uppgörelser med krig och kolonialism. I denna avhandling studeras gottgörelse för kränkningar i samband med sociala interventioner.I In 1999 the Swedish Parliament decided to provide economic compensation to victims of involuntary sterilization, and in 2012 a similar law was enacted to redress neglect and abuse in foster homes and orphanages. This study explores the dilemmas that arise with reparations for past injustices, focusing on the process leading up to the reparation laws. Four themes are investigated: [1] state redress
Oligodendrocytes are part of the glial cells located in the central nervous system, capable of providing trophic support to neurons and ensheathing their axons. These cells can become dysfunctional under pathologic condition. Rodent and human pluripotent stem cells are inexhaustible sources for producing oligodendrocytes that can be used for disease modeling and cell replacement therapy studies. T
The complement system is an arm of innate immunity that aids in the removal of pathogens and dying cells. Due to its harmful, pro-inflammatory potential, complement is controlled by several soluble and membrane-bound inhibitors. This family of complement regulators has been recently extended by the discovery of several new members, and it is becoming apparent that these proteins harbour additional
BACKGROUND: An adequate amount of prepaid resources for health is important to ensure access to health services and for the pursuit of universal health coverage. Previous studies on global health financing have described the relationship between economic development and health financing. In this study, we further explore global health financing trends and examine how the sources of funds used, typ
OBJECTIVES: To elucidate the role of genital infections in last trimester pre-labour foetal death and the role and aetiology of chorioamnionitis in stillbirth in Maputo, Mozambique. To determine the role of current syphilis as a risk factor for foetal death in Maputo and the prevalence and risk factors for syphilis and HIV infection in displaced pregnant women in rural Zambezia province. To evalua
Autoimmune (type 1) diabetes (AI-DM) is a multistage disorder. Children are born genetically predisposed to putative environmental exposures. These trigger an aggressive, selective and chronic autoimmune response against the pancreatic islet beta cells. This stage is marked by autoantibodies against insulin, glutamic acid decarboxylase (GAD65), IA-2 and the ZnT8 transporter. Progression to clinica
Popular Abstract in Swedish Studien handlar om fysiologen Frithiof Holmgrens försök att fastställa seendets natur på experimentell väg. Avsikten är att problematisera Holmgrens intresse för synsinnet mot bakgrund av de metoder och vetenskapliga ideal som var förhärskande inom den experimentella fysiologin, det ämne som Holmgren introducerade i Sverige 1862. Generellt kan man säga att Holmgrens forThis study deals with research on the visual organ as pursued in experimental physiology during the latter half of the nineteenth-century. In the 1850's och 60's experimental physiology developed as a new, scientific discipline within the curriculum of western medicine. By opposing the natural philosophical and vitalistic viewpoint of romantic medicine and by proclaiming measuring devices, animal
Popular Abstract in Swedish Nollvisionen antagen av Sveriges riksdag fastlägger att ingen skall behöva dödas eller skadas svårt i trafiken i Sverige. Införande av detta begrepp förskjuter fokus från trafikolyckorna till konsekvenserna av trafikolyckorna och härmed skapas förutsättningar för ett paradigmskifte i trafiksäkerhetsarbetet. För att åstadkomma önskade förändringar är det nödvändigt och bThe over-arching objectives of this thesis were to formulate a method to describe the consequences of traffic casualties, and to explain the influence of different traffic engineering factors on these consequences for society and individuals over time. A more detailed objective was to examine whether available short-term indicators can be used to predict consequences in a long-term perspective. Ot
A 12-year-old girl with multifocal skeletal sclerosis has been investigated. She was BCG vaccinated at birth and developed regional lymphadenitis in her left groin at two months of age. She was healthy until approximately 10 years of age, after which deficient height and weight gain occurred. BCG-itis was diagnosed in skeleton lesions. No evidence of immunodeficiency was found in the patient. Afte
In addition to acting as a physical barrier against microorganisms, the skin produces antimicrobial peptides and proteins. After wounding, growth factors are produced to stimulate the regeneration of tissue. The growth factor response ceases after regeneration of the tissue, when the physical barrier protecting against microbial infections is re-established. We found that the growth factors import
Rodent models have been developed to study the pathogenesis of diseases caused by Helicobacter pylori, as well as by other gastric and intestinal Helicobacter spp., but some murine enteric Helicobacter spp. cause hepatobiliary and intestinal tract diseases in specific inbred strains of laboratory mice. To identify these murine Helicobacter spp., we developed an assay based on PCR-denaturing gradie
