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Serglycin (SG) is a proteoglycan expressed by hematopoietic cells and is constitutively secreted by multiple myeloma (MM) cells. SG participates in the regulation of various inflammatory events. We found that SG secreted by human MM cell lines inhibits both the classical and lectin pathways of complement, without influencing alternative pathway activity. The inhibitory effect of SG is due to direc
This paper describes searches for the pair production of first or second generation scalar leptoquarks using 35 pb(-1) of proton-proton collision data recorded by the ATLAS detector at root s = 7 TeV. Leptoquarks are searched in events with two oppositely-charged muons or electrons and at least two jets, and in events with one muon or electron, missing transverse momentum and at least two jets. Af
BACKGROUND: The clinically significant antigens of the Duffy (Fy [FY]) blood group system are expressed on the red cell form of the FY glycoprotein, a promiscuous chemokine receptor and also a receptor for malarial parasites. After the cloning of cDNA coding for FY glycoprotein, the molecular basis of the three major alleles (Fya/Fyb/Fy) has been established. Because of the mistyping of the silent
The aims were to study the biological, socio-demographic and psychosocial health profile in a geographically defined population of middle-aged women, with focus on features of the metabolic syndrome and diabetes, and to study the efficiency of a screening method for high-risk individuals and the outcome of baseline lifestyle advices on the diabetes incidence. All women aged 50-59 years (n=10766)
Life cycle assessment and life cycle cost analysis are suitable tools in trying to minimize environmental impact and cost. To get reliable results it is crucial to set up correct system boundaries for the investigation, but it is often difficult to understand a complex products system because of the cascade effects of consequences that can be induced even by small changes. In this paper the effect
Background: Clinical tools to diagnose the early changes of osteoarthritis (OA) that occur in the articular cartilage are lacking. Objectives: We sought to identify and quantify a novel cartilage oligomeric matrix protein (COMP) neoepitope in the synovial fluid from the joints of healthy horses and those with different stages of OA. Study design: In vitro quantitative proteomics and assay developm
IntroductionThe Multidimensional Pain Inventory (MPI) is frequently used in the assessment of chronic pain. Three subgroups have been derived from MPI: Adaptive Coper (AC), Dysfunctional (DYS) and Interpersonally Distressed (ID). The primary aim of was to examine whether outcome of Interdisciplinary Multimodal Pain Rehabilitation Programs (IMMRPs) differed across the MPI subgroups.MethodsChronic p
The enzyme NUDT15 efficiently hydrolyses the active metabolites of thiopurine drugs, which are routinely used for treating cancer and inflammatory diseases. Loss-of-function variants in NUDT15 are strongly associated with thiopurine intolerance, such as leukopenia, and pre-emptive NUDT15 genotyping has been clinically implemented to personalize thiopurine dosing. However, understanding the molecul
The geomagnetic dipole moment (GDM) modulates the production rates of cosmogenic radionuclides via the shielding of galactic cosmic rays. Therefore, it is possible to use this linkage to reconstruct past changes in the GDM based on cosmogenic radionuclide records from natural archives such as ice cores. Here we present a GDM reconstruction based on 10Be and 36Cl data from two Greenland ice cores f
Proof load testing may be performed to confirm the reliability of the bridge for an existing classification or to prove the reliability for a higher classification.In this paper, a probabilistic decision analysisapproach is applied to the scenario for the evaluation of target proof load in the situation where information on the bridge resistance model is lacking. In this case, the resistance model
This paper reports searches for heavy resonances decaying into ZZ or ZW using data from proton-proton collisions at a centre-of-mass energy of s=13 TeV. The data, corresponding to an integrated luminosity of 36.1 fb−1, were recorded with the ATLAS detector in 2015 and 2016 at the Large Hadron Collider. The searches are performed in final states in which one Z boson decays into either a pair of lig
Charged Higgs bosons heavier than the top quark and decaying via H± → tb are searched for in proton-proton collisions measured with the ATLAS experiment at (Formula presented.) TeV corresponding to an integrated luminosity of 20.3fb−1. The production of a charged Higgs boson in association with a top quark, gb → tH±, is explored in the mass range 200 to 600 GeV using multi-jet final states with on
Abstract: A search is conducted for new physics in multijet final states using 3.6 inverse femtobarns of data from proton-proton collisions at (Formula presented.) TeV taken at the CERN Large Hadron Collider with the ATLAS detector. Events are selected containing at least three jets with scalar sum of jet transverse momenta (HT) greater than 1 TeV. No excess is seen at large HTand limits are prese
Summer music festivals that involve a few days of camping have often been linked to sustainability agendas. Yet relevant studies have so far overlooked how these events can themselves serve as experiments in less resource consumptive living. Building on a wider interest in the cultural evolution of cleanliness norms, this paper explores how attendees come to use water in personal washing at two UK
Adolescents have a unique developmental vulnerability to suicide, with youth presenting as the second most vulnerable group to suicide across the lifespan. Youth have been recognized as underserved mental health service recipients, with only one in six of those in need receiving care. Calls for innovative mental health services to better serve youth have been articulated for over a decade and the
A search is conducted for new resonant and non-resonant high-mass phenomena in dielectron and dimuon final states. The search uses 36.1 fb−1 of proton-proton collision data, collected at s=13 TeV by the ATLAS experiment at the LHC in 2015 and 2016. No significant deviation from the Standard Model prediction is observed. Upper limits at 95% credibility level are set on the cross-section times branc
Background. Patients use self-care to relieve symptoms of common colds, yet little is known about the prevalence and patterns across Europe. Methods/Design. In a cross-sectional study 27 primary care practices from 14 countries distributed 120 questionnaires to consecutive patients (≥18 years, any reason for consultation). A 27-item questionnaire asked for patients' self-care for their last common
