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Introduction: The thrombin generation assay-calibrated automated thrombogram (TGA-CAT) method is used to measure the overall coagulation capacity in plasma. However, the method is still considered to be a research tool, mainly because of its’ lack of standardization. Aim: Our study aimed to further raise the standardization level for the TGA-CAT method by evaluating a detailed standardization prot
Background aims: Cell-based therapies of pulmonary diseases with mesenchymal stromal cells (MSCs) are increasingly under experimental investigation. In most of these, MSCs are administered intravenously or by direct intratracheal instillation. A parallel approach is to administer the cells into the lung by endoscopic atomization (spraying). In a previous study, the authors developed a flexible end
In this paper, a numerical study of flow, reactions and NOx emissions from a biomass boiler is presented. Detailed reaction mechanisms for the decomposition of tar species, combustion of hydrocarbons and formation of NOx are employed by adopting appropriate reaction sets from literature. The proposed mechanism is used to perform CFD simulations of a laboratory-scale biomass boiler, and temperature
Digital holography (DH) has been extensively applied in particle field measurements due to its promising ability to simultaneously provide the three-dimensional location and in-plane size of particles. Particle detection methods are crucial in hologram data processing to determine particle size and particle in-focus depth, which directly affect the measurement accuracy and robustness of DH. In thi
Due to its compatible oxygen-transporting abilities, hemoglobin (Hb) is a protein of interest in the development of artificial oxygen therapeutics. Despite continuous formulation attempts, extracellular Hb solution often exhibits undesirable reactions when applied in vivo. Therefore, protein engineering is frequently used to examine alternative ways of controlling the unwanted reactions linked to
The natural products pulchrol and pulchral, isolated from the roots of the Mexican plant Bourreria pulchra, have previously been shown to possess an antiparasitic activity toward Trypanosoma cruzi, Leishmania braziliensis and L. amazonensis, protozoa responsible for the Chagas disease and leishmaniasis. These infections have been classified as neglected diseases, and still require the development
In 1876, the Kaitakushi, the Japanese government agency responsible for the settlement of the northern island of Hokkaido, hired three Americans from Massachusetts Agricultural College: William Smith Clark, William Wheeler and David Pearce Penhallow. Their task was to establish a comparable institution in Hokkaido, Sapporo Agricultural College, that would spread American-style scientific agricultu
The efficiency of irrigation, as well as optimization of nutrients, affect spinach yield in all growth stages. In this study, the sensitivity of spinach (early and mature yields) to shallow saline groundwater and the effect of fertigation treatments on mature yield were experimentally investigated. The sprinkler irrigation experiments were conducted on 0.47 ha of silty clay soil at the University
Dupuytren’s disease (DD) is a fibroproliferative disorder affecting the palmar fascia of the hand. Risk factors include diabetes mellitus (DM), whereas a high body mass index (BMI) is associated with a lower prevalence of DD. The aim of this study was to further elucidate risk and protective factors for the development of DD using longitudinal population-based data from the Malmö Diet and Cancer S
The use of stem cell derived dopamine neurons for treating patients with Parkinson's disease has now evolved to the first in human clinical trials. In this debate, we argue that assuming these trials give positive outcomes that this therapy will supercede DBS as the neurosurgical treatment of choice for PD patients in the future given it is a one-off therapy that repairs a critical pathway in the
Background & Aims: In 2014, the burden of hepatitis C virus (HCV) in Sweden was evaluated, to establish a baseline and inform public health interventions. Considering the changing landscape of HCV treatment, prevention, and care, and in light of the COVID-19 pandemic, this analysis seeks to evaluate Sweden's progress towards the World Health Organization (WHO) elimination targets and identify
Diamond-Blackfan anemia (DBA) is a congenital erythroid hypoplasia caused by a functional haploinsufficiency of genes coding for ribosomal proteins. Among these genes, the ribosomal protein S19 (RPS19) gene is the most frequently mutated. Previously, a mouse model deficient in RPS19 was developed by our laboratory, which recapitulates the hematopoietic disease phenotype by manifesting pathologic f
Climate mitigation scenarios envision considerable growth of wind and solar power, but scholars disagree on how this growth compares with historical trends. Here we fit growth models to wind and solar trajectories to identify countries in which growth has already stabilized after the initial acceleration. National growth has followed S-curves to reach maximum annual rates of 0.8% (interquartile ra
The activity-size distribution of radiocolloids has been studied using gel-chromatography scanning (GCS) of columns filled with Sepharose 4B gel. Rabbits were injected subcutaneously with the colloid of interest, laid supine beneath a gamma camera, and imaged every 15 sec for 2 to 4 hr. From the stored data, the uptakes in the parasternal lymph nodes were analyzed in terms of a two-compartment mod
A software prototype is developed for assessing and updating the reliability of single-cell prestressed concrete box girders subjected to chloride-induced reinforcement corrosion. The underlying system model consists of two integrated sub-models: a condition model for predicting the deterioration state of the box girder and a structural model for evaluating the overall system reliability. The cond
Thefirst reported applications of laser sheet imaging for the study of atomizing sprays date from the mid 1980th.Since those early tries, blurring effects from the light being scattered multiple times by the surrounding dropletswere already observed and reported. While s trategies in suppressing part of this multiple light scatteringcontribution, were known for transmission imaging (e. spatial Fou
The higher vibrational levels of the C 1s→π* excitation in carbon monooxide (CO) were investigated by using resonant Auger electron spectroscopy. The absorption profile of the CO was recorded in the partial electron yield mode. The results showed that the vibrational states were not seen in a total yield absorption spectrum whereas they were shown to be discernable in a partial electron yield spec
