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This is the third of three chapters on diffusion MRI acquisition for tractography. Tractography is performed extensively in the in vivo adult brain, and sequences used for the in vivo adult brain have been covered in detail in Chapter 7. However, tractography is also performed in ex vivo human brain, in both the in vivo and ex vivo animal brain of various nonhuman species, in the human brain durin
With the advent of digitalization, the economy of the world is quickly changing itself and Indian Small and Medium Enterprises (SMEs) are the front runners. This study sheds light on how digital transformation is crucial to support the growth, competitiveness, and sustainability in the present business environment, and how digital transformation is important to the SMEs in India. To encourage SMEs
Recent years have seen a sharply rising interest in the scientific area dedicated to the study of the use of Artificial Intelligence (AI) for Cognitive Behavioral Therapy (CBT) research and applications (AI4CBT for brevity). Yet, little is known about how this interest is realized and hence the overall status, prospects, and possible challenges of AI4CBT as a field (e.g. breadth of the field, key
INTRODUCTION: Biomarkers play a crucial role in understanding Alzheimer's disease (AD) pathogenesis and treatment effects. However, comparing biomarker measures without standardization and appreciating their magnitude relative to the disease can be challenging. METHODS: To address this issue, we propose the CentiMarker approach, similar to Centiloid, which provides a standardized scale between nor
Corrosion of steel components embedded in concrete is detrimental to the structural integrity and their intrinsic function,such as the leak-tightness of containment liners in nuclear reactor containment buildings. Detection of embedded linercorrosion is a challenging task due to the concrete’s heterogeneity and the large dimensions of containment buildings.This initial study explores early-stage d
Purpose: To describe a novel technique for optimal orientation and accurate deployment of aortic endografts during complex endovascular aortic repair (cEVAR). Technique: After establishing the femoral access in the standard fashion, a long large-bore dilator is inserted before the cEVAR delivery system. The dilator is advanced beyond the renovisceral segment noticing the degree of axial rotation.
DNA-encoded chemical libraries are increasingly used in pharmaceutical research because they enable the rapid discovery of synthetic protein ligands. Here we explored whether target-class focused DNA-encoded chemical libraries can be cost-effective tools to achieve robust screening productivity for a series of proteins. The study revealed that a DNA-encoded library designed for NAD+-binding pocket
Male gametogenesis occurs directly after uptake of malaria parasites by the mosquito vector and leads to the release of eight nucleated flagellar gametes. Here, we report that one of the two parasite actin isoforms, named actin II, is essential for this process. Disruption of actin II in Plasmodium berghei resulted in viable asexual blood stages, but male gametogenesis was specifically inhibited.
This paper introduces a conceptual framework: the CPS triangle, which has evolved over four years of research on ‘older people meet robots’. It is a synthesis of domestication theory, modern social practice theory and empirical data. Case studies on the domestication of one current technology, the robotic vacuum cleaner, and two emergent technologies, the eHealth system and the service robot, prov
Numerous theories of distributive fairness promote the idea that we ought to give extra weight to benefits to the worse off and can thereby be seen as promoting gap closures. This paper underlines the relevance of making a distinction between attainable and ideal target levels for individuals in populations affected by distributive fairness and show that in cases of scarce resources, theories that
The Swedish Campaign for Nuclear Disarmament (SCND) fought the military’s plans to acquire Swedish nuclear weapons and protested the nuclear arms race, 1961–1967. This article presents SCND’s ideological orientation by focusing on temporalities. SCND saw the Second World War as a decisive event and tried to avert a crisis and a dystopia by manifesting remembrance of past nuclear detonations, and b
This study analyzes the current state of artificial intelligence (AI) technologies for addressing and mitigating climate change in the manufacturing sector and provides an outlook on future developments. The research is grounded in the concept of general-purpose technologies, motivated by a still limited understanding of innovation patterns for this application context. To this end, we focus on gl
Family disaster planning and preparation demands proactive acknowledgment and accommodation of individuals with disabilities. This study, based on interviews with families including members with disabilities, uncovers insights on information gaps, adaptive strategies, technology use, and support networks. Contributing to disaster and disability studies, resilience, and crisis planning, it highligh
Oxidative stress plays a crucial role in the development of several liver diseases. Many natural polyphenols can attenuate oxidative stress and liver injury. In this study, a phytochemical profiling of a methanol extract from leaves of Syzygium samarangense revealed 92 compounds belonging to flavonoids, phenolic acids, condensed tannins, and ellagitannins. The S. samarangense extract exhibited a n
The power take-off (PTO) system and control laws for wave energy converters (WECs) are crucial for system performance. Determining optimal PTO parameters based on different sea states is key for formulating control laws, identifying optimal WEC locations, and optimizing wave-to-wire performance. This study focuses on an oscillating water column (OWC) type WEC developed by Waves4Power using a buoy
This chapter explores the interaction between competition law and especially Article 101(3) TFEU and environmental and climate change goals in the context of the EU’s Green Deal and the aim of energy transition. First, it reviews the evolution of the Commission’s and national authorities’ approaches to environmental and climate benefits in their general assessment of horizontal and vertical agreem
We use density-matrix simulations to study the performance of three distance three quantum error correction (QEC) codes in the context of the rare-earth (RE) ion-doped crystal platform for quantum computing. We analyze pseudothresholds for these codes when parallel operations are not available, and examine the behavior both with and without resting errors. In RE systems, resting errors can be miti
This article explores the burgeoning Nepalese hip-hop scene – commonly known as nep-hop – as a discursive intervention in the post-war politics of Nepal. Its core argument is that nep-hop oftentimes demonstrates an ethos of peacebuilding through popular culture. Indeed, many songs explicitly criticize violence, war, and the political leaders who recently brought the nation to a civil war. Yet, thi
