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This paper reports on research on the engagement of ISO 14001 certified companies in environmental supply chain management, the drivers and barriers that influence their involvement, and how these forces correspond to the internal environmental management activities. In parallel, the issues of internal capabilities of companies, crucial for companies to respond to such driving forces, are highligh
What would it be like if we said one thing, and heard ourselves saying something else? Would we notice something was wrong? Or would we believe we said the thing we heard? Is feedback of our own speech only used to detect errors, or does it also help to specify the meaning of what we say? Comparator models of self-monitoring favor the first alternative, and hold that our sense of agency is given b
A key to successful chronic neural interfacing is to achieve minimal glial scarring surrounding the implants, as the astrocytes and microglia may functionally insulate the interface. A possible explanation for the development of these reactions is mechanical forces arising between the implants and the brain. Here, we show that the difference between the density of neural probes and that of the tis
Cross-sectional studies have reported strong correlations between plasma levels of complement C3, insulin, and glucose. This prospective study explored whether elevated levels of C3, C4, and other inflammation-sensitive plasma proteins (ISPs; fibrinogen, orosomucoid, α1-antitrypsin, haptoglobin, and ceruloplasmin) are associated with the development of diabetes. Plasma proteins were measured in 2,
Chemokines are important in the development and progression of tumors. We investigated the expression of CXCL14 and CXCL16 in colon cancer. Expression of mRNA was assessed in primary tumors and lymph nodes and CXCL16 mRNA levels were correlated to patient’s survival. Protein expression was investigated by two-color immunofluorescence and immunomorphometry. CXCL14 and CXCL16 mRNA levels and protein
Fredrik NG Andersson and Lars Jonung argue that the current push for fiscal activism is short-sighted. Instead, the Swedish case from the last 25 years shows that stable public finances combined with supply-side policies is the recipe for economic stability and growth.
WNT5A is a well-known mediator of melanoma cell invasion and metastasis via its ability to activate protein kinase C (PKC), which is monitored by phosphorylation of the endogenous PKC substrate myristoylated alanine-rich c-kinase substrate (MARCKS). However, a possible direct contribution of MARCKS in WNT5A-mediated melanoma cell invasion has not been investigated. Analyses of melanoma patient dat
Voltage-gated Ca2+ (CaV) channels trigger glucose-induced insulin secretion in pancreatic beta-cell and their dysfunction increases diabetes risk. These heteromeric complexes include the main subunit alpha1, and the accessory ones, including subunit gamma that remains unexplored. Here, we demonstrate that CaV gamma subunit 4 (CaVγ4) is downregulated in islets from human donors with diabetes, diabe
This review focuses on the most recent literature concerning flow cytometry (FCM) application for diagnosis of myelodysplastic syndrome (MDS). Aberrant FCM results have been defined as abnormalities in at least three tested features comprising at least two bone marrow (BM) cell compartments. FCM results should be interpreted together with the BM smear cytology, the morphological assessment of BM b
In linguistics and in the philosophy of language it is standardly assumed that know is a factive verb, meaning that a sentence such as X knows that p, when uttered in its positive declarative form, presupposes, in fact entails, the truth of its complement. A problem for this analysis is the fact that the verb know can be used non-factively in contexts where it is evident that the proposition expre
The sharing economy has many faces, and it has taken our societies by storm. For many people, it has quickly become a norm to book accommodation via AirBnB, or to think sharing instead of owning when it comes to products of their everyday lives. The tourism industry has seen many adaptions towards a sharing economy, one of them being a new way of conducting guided tours. Based on an innovation in
Purpose: The FANCM c.5101C>T nonsense mutation was previously found to associate with breast cancer in the Finnish population, especially among triple-negative cases. Here, we studied the prevalence of three other FANCM variants: c.5791C>T, which has been reported to predispose to familial breast cancer, and the c.4025_4026delCT and c.5293dupA variants recently identified in Finnish cancer patient
Pigment epithelium derived factor (PEDF), a ubiquitously expressed 50 kDa secreted glycoprotein, was recently discovered to regulate self-renewal of neural stem cells and have a supportive effect on human embryonic stem cell growth. Here, we analyzed expression of PEDF in the murine hematopoietic stem cell (HSC) compartments and found that PEDF is highly expressed in primary long-term HSCs. Theref
The intramedullary skeletal kinetic distractor (ISKD) is one of the relatively recent methods developed to overcome the complications of conventional bone lengthening methods, such as external fixators. These complications include pain, muscle transfixation, pin-tract infection, reduced joint motion, and prolonged fixation time. However, ISKD-specific complications such as uncontrollable lengtheni
Climate change and direct anthropogenic impact are recognized as two major factors affecting catchment runoff. This study investigated the separate effect of each of these factors for runoff from the important Tunisian Merguellil catchment. For this purpose, more than forty years of hydrological data were used. The methodology was based on hydrological characterization, NDVI index to monitor land
