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Toxin-antitoxin (TA) gene pairs are ubiquitous in microbial chromosomal genomes and plasmids as well as temperate bacteriophages. They act as regulatory switches, with the toxin limiting the growth of bacteria and archaea by compromising diverse essential cellular targets and the antitoxin counteracting the toxic effect. To uncover previously uncharted TA diversity across microbes and bacteriophag
This article, Part II of an article series on GPU-accelerated Monte Carlo simulation of photon transport through turbid media, focuses on the validation of the online software Multi-Scattering. While Part I detailed the implementation of the computational model, simulated and experimental results are now compared for the distribution of the scattered light intensity. The scattering phantoms prepar
Spontaneous magnetic alignment is the simplest known directional response to the geomagnetic field that animals perform. Magnetic alignment is not a goal directed response and its relevance in the context of orientation and navigation has received little attention. Migratory songbirds, long-standing model organisms for studying magnetosensation, have recently been reported to align their body with
The paper explores knowledge recombination by analysing how knowledge networks in established technological fields influenced the formation of the emerging field of green shipping in the period 2007–2018. Previous research has demonstrated that embeddedness, proximity, and status are important mechanisms for the evolution of single technological fields. We investigate if these mechanisms also appl
We provide a comparative analysis of qualitative features of different numerical methods for the inhomogeneous geometric Brownian motion (IGBM). The limit distribution of the IGBM exists, its conditional and asymptotic mean and variance are known and the process can be characterised according to Feller's boundary classification. We compare the frequently used Euler–Maruyama and Milstein methods, t
Background: High intake of added sugar have been suggested to impact the risk for cardiovascular disease (CVD). Knowledge on the subject can contribute to preventing CVD. Objectives: To assess the effects of a high versus low-added sugar consumption for primary prevention of CVD in the general population. Search methods: We searched Cochrane Central Register of Controlled Trials (CENTRAL) in the C
The Cherenkov Telescope Array (CTA) will be the next-generation observatory in the field of very-high-energy (20 GeV to 300 TeV) gamma-ray astroparticle physics. Classically, data analysis in the field maximizes sensitivity by applying quality cuts on the data acquired. These cuts, optimized using Monte Carlo simulations, select higher quality events from the initial dataset. Subsequent steps of t
In the last two decades, very-high-energy gamma-ray astronomy has reached maturity: over 200 sources have been detected, both Galactic and extragalactic, by ground-based experiments. At present, Active Galactic Nuclei (AGN) make up about 40% of the more than 200 sources detected at very high energies with ground-based telescopes, the majority of which are blazars, i.e. their jets are closely align
The petrochemicals industry (mainly plastics and fertilizer production) is expanding, despite increasing attention to the environmental impact of petrochemicals. In our paper, we explore the role public finance plays in the petrochemicals industry. We do so by mapping the public and private financial flows into large-scale petrochemical projects for the decade 2010-20 and discuss the role of publi
A survey of nuclear structure results obtained along α-decay chains stemming from isotopes of element 114, Fl, and element 115, Mc, is presented. Measures taken to ensure a reliable hand-over of nuclear spectroscopy output to nuclear structure theory are outlined. Possible links between decay chains starting from element 117, Ts, and element 115, Mc, are commented on. The experiments were conducte
In this paper, we present a new account of teleological reasons, i.e. reasons to perform a particular action because of the outcomes it promotes. Our account gives the desired verdict in a number of difficult cases, including cases of overdetermination and non-threshold cases like Parfit’s famous Drops of water. The key to our account is to look more closely at the metaphysics of causation. Accord
We report on the development of a method based on recombinant yeast Saccharomyces cerevisiae to produce nonivamide, a capsaicinoid and potent agonist of the pain receptor TRPV1. Nonivamide was produced in a two-step batch process where yeast was i) grown aerobically on glucose and ii) used to produce nonivamide from vanillin and non-anoic acid by bioconversion. The yeast was engineered to express
Faithful modeling of tissues and organs requires the development of systems reflecting their dynamic 3D cellular architecture and organization. Current technologies suffer from a lack of design flexibility and complex prototyping, preventing their broad adoption by the scientific community. To make 3D cell culture more available and adaptable we here describe the use of the fused deposition modeli
Leaf functional traits are key indicators of plant functions useful for inferring complex plant processes, including their responses to environmental changes. Vegetation indices (VIs) composed of a few reflectance wavelengths hold the advantages of being relatively simple and effective and have been widely used within remote sensing to estimate leaf traits. However, the difference between the refl
The petrochemicals industry (mainly plastics and fertilizer production) is expanding, despite increasing attention to the environmental impact of petrochemicals. In our paper, we explore the role public finance plays in the petrochemicals industry. We do so by mapping the public and private financial flows into large-scale petrochemical projects for the decade 2010-20 and discuss the role of publi
In the quest for the development of faster and more reliable technologies, the ability to control the propagation, confinement, and emission of light has become crucial. The design of guide mode resonators and perfect absorbers has proven to be of fundamental importance. In this project, we consider the shape optimization of a periodic dielectric slab aiming at efficient directional routing of lig
Meshless methods are a promising new field in computational electromagnetics. Instead of relying on an explicit mesh topology, a numerical solution is computed on an unstructured set of collocation nodes. This allows to model fine geometrical details with high accuracy and facilitates the adaptation of node distributions for optimization or refinement purposes. The radial point interpolation metho
