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The Design and Structure Prediction of Protein Oligomers

The minimum free energy state of a protein (the native state) is encoded by its amino-acid sequence. Due to the many torsional degrees of freedom (DOF) available to a polypeptide chain, a vast number of conformations is possible. Therefore, to predict the native state of a protein directly from sequence, a computer algorithm must evaluate a large number of possible conformations using accurate sco

Assessment of Computational Methods for Ligand Binding

Most drugs act on biomacromolecules. The Cost of developing new drugs is very high. A method to accurately predict binding affinities would be very useful. We have studied molecular mechanics with generalised Born and surface--area solvation (MM/GBSA) and alchemical free energy perturbation methods (FEP) for use in calculations of ligand binding energies. For the MM/GBSA method we have tested: Ca

The evolution of respiratory chain complex I from smaller functional modules

NADH:quinone oxidoreductase, or complex I, is a large membrane bound enzyme in the respiratory chain of living organisms, that has evolved from the combination of smaller functional building blocks. The enzyme has a conserved core structure, comprising 14 protein subunits: Seven subunits protrude from the membrane and contain a flavin and eight iron-sulfur clusters. The remaining seven subunits in

Science and proven experience : a Swedish variety of evidence-based medicine?

A key question for evidence-based medicine (EBM) is how best to model the way in which EBM should “[integrate] individual clinical expertise and the best external evidence” (Sackett et al. 1996). We argue that the formulations and models available in the literature today are modest variations on a common theme and face very similar problems. For example, both the early and updated models of eviden

Critical and Pedagogical Studies - Exam Projects 2017

Den här artikeln är över 5 år gammal, och informationen kan därför vara inaktuell. This spring students in the Critical & Pedagogical Studies Programme at Malmö Art Academy will present their exam projects towards the completion of a Master of Fine Arts degree. The exam projects will lead to several weeks of diverse activities which will discuss and reflect different critical and pedagogical aspec

https://www.khm.lu.se/artikel/critical-and-pedagogical-studies-exam-projects-2017 - 2026-05-29

LU-gemensamt Mejlutskick Nr 2-v 3-2021

NYTT FRÅN LUNDS UNIVERSITET Mejlutskick på svenska och engelska som vänder sig till fakultetskommunikatörer vid Lunds universitet för vidarespridning i fakultets- och institutionskanaler – Nr 2 v 3 - 2021. CORONARELATERAT Uppdaterat rektorsbeslut 18 januari: rådande restriktioner gäller tills vidare Rektorsbeslutet från 18 januari följer dessa restriktioner och gäller tills vidare för att ge verks

https://www.cec.lu.se/sites/cec.lu.se/files/2021-02/LU-gemensamt%20Mejlutskick%20Nr%202-v%203-2021.pdf - 2026-05-30

The 5 ' Region of the MSH2 gene involved in hereditary non-polyposis colorectal cancer contains a high density of recombinogenic sequences

MSH2 rearrangements are involved in approximately 10% of hereditary non,polyposis colorectal cancer (HNPCC) families, and in most of the rearrangements, exon I is deleted. We scanned by quantitative multiplex polymerase chain reaction (PCR) of short fluorescent fragments (QMPSF) 200 kb of genomic sequences upstream of the MSH2 transcription initiation site in 21 HNPCC families with exon I deletion

MDC diet history

The modified diet history methodology of the Malmö Diet Cancer cohort2016-09-05Edited by Elisabet Wirfält and Emily Sonestedt Resource persons:Dietary data collection at baseline: Ulrika Ericson (ulrika [dot] ericson [at] med [dot] lu [dot] se)Peter Wallström (especially supplements) (peter [dot] wallstrom [at] med [dot] lu [dot] se (peter[dot]vallstrom[at]med[dot]lu[dot]se)) Consultation on dieta

https://www.malmo-kohorter.lu.se/malmo-kost-cancer-mkc/mkc-kostmetod/mdc-diet-history - 2026-05-29

Fika for a Livable Future: Knowledge, Community and Climate Action

17 april 2026 15:00 till 16:00 | Övrigt Our Climate Café facilitate conversations about and collaboration on climate related topics and empower everyday thoughts and actions towards sustainable futures. Together we will explore what makes us worried, angry, inspired and hopeful, as we navigate an increasingly complex world. Did you know that worry and guilt become more manageable when shared, and

https://www.lu.se/evenemang/fika-livable-future-knowledge-community-and-climate-action - 2026-05-30

Humboldt and the Modern German University : An Intellectual History

This book is about the idea of the university in modern Germany. Its primary focus is how the transformation of the Humboldtian tradition gave direction to debates around higher education. By combining approaches from intellectual history, conceptual history and the history of knowledge, the study investigates the ways in which Humboldt’s ideas have been appropriated for various purposes in differ