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Tolerance induction with T cell-dependent protein antigens induces regulatory sialylated IgGs

Background: Under inflammatory conditions, T cell-dependent (TD) protein antigens induce proinflammatory T-and B-cell responses. In contrast, tolerance induction by TD antigens without costimulation triggers the development of regulatory T cells. Under both conditions, IgG antibodies are generated, but whether they have different immunoregulatory functions remains elusive. Objective: It was shown

The Role of Small-Bowel Capsule Endoscopy in the Diagnostic Algorithm of Complicated Perianal Disease

Introduction: Complicated perianal disease (cPD) may be the sole presentation of Crohn’s disease (CD). The role of small-bowel capsule endoscopy (SBCE) in the diagnostic algorithm of cPD is unclear. We aimed to evaluate the role of SBCE as a diagnostic tool, in patients with cPD, after a negative standard workup for CD. Methods: A multicenter, retrospective, cross-sectional study, in patients with

Muskelsjukdom

Malign hypertermikänslighet Malign hypertermikänslighet (malign hypertermi MH) är en ärftlig muskelåkomma, där narkos kan utlösa en potentiellt dödande ökning av ämnesomsättningen. Utredning sker huvudsakligen med hjälp av en öppen muskelbiopsi, i vissa fall med mutationsdiagnostik. MH enheten i Lund är ett nationellt centrum. Vår forskning har två huvudinriktningar Genetik: Vi har samarbete meMalign hypertermikänslighet Malignant hyperthermia is a hereditary muscle disease, which can be triggered by anesthesia. This may result in a potentially life-threatening increase in the metabolism. Evaluation of the patients occurs mainly through muscle biopsi, sometimes with mutation diagnostica. The MH unit i Lund is a national centra. The reasech can be divided in 2 parts: Genetic: The aim o

Molekylär Neurofysiologi och Epilepsi

Epilepsy is a devastating neurological disorder characterized by synchronous neuronal activity, which manifests as epileptic seizures. It usually develops after an initial insult, such as head trauma or stroke, which triggers the epileptogenic process. During epileptogenesis, the affected brain regions undergo multiple changes in connectivity and gene expression, and among the most affected genes

Securing the child´s best interest for unaccompanied minors living in group homes

This study focuses on the part of the policy process called implementation. Theorists like Lipsky (1980) and Rice (2012) assign the street-level bureaucrats a major role in this process. The street-level bureaucrats of object in this study are personnel on group homes for unaccompanied minors. Since the children do not have anyone else to look after them, it is the welfare states responsibility to

Minimalinvasiv hjärtkirurgi vid hjärtklaffsjukdom

Minimalinvasiv hjärtkirurgi definieras som hjärtkirurgiska operationstekniker där man avstår från en full median sternotomin (längsgående delning av hela bröstbenet). Hjärtoperationen sker då istället med alternativa exponeringstekniker under det att man använder konventionell hjärt-lungmaskin. Beroende på diagnos utförs antingen operationen med video-assisterad, eller robot-assisterad, endoskopi Minimally invasive cardiac surgery is defined a cardiac surgery with heart-lung machine, but without full median sternotomy. Depending on the underlying disease the surgical procedures can be performed through a 4-6 cm mini-thoracotomy on the right side with either video-assisted or robotic-asssited endoscopy or through a partial split of the sternum. We believe that minimally invasive facilitate