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The Wilms tumor gene, WT1, encodes a zinc-finger DNA binding protein which is thought to function as a tissue specific transcription factor, regulating cell growth and differentiation. High expression of WT1 has been detected in a range of acute leukemias. To elucidate a role for WT1 in leukemogenesis, we transfected the monoblastic cell line U937, which lacks detectable levels of endogenous WT1,
The scope of this presentation is a new methodology to correct conventional NIR data for scattering effects. The technique aims at measuring the absorption coefficient of the samples rather than the total attenuation, measured by conventional NIR spectroscopy. The main advantage of this is that the absorption coefficient is independent of the path length of the light inside the sample, and therefo
In 2010, unmet medical care and sexual health counseling needs were assessed among students at a Ugandan University. Unmet medical care need was associated with poor mental health, experience of sexual coercion, and poor self-rated health. Unmet sexual health counseling need was significantly associated with being female, coming from an urban area, low social participation, poor mental health stat
Energy-dispersive X-ray fluorescence (EDXRF) spectrometry is not adequate for the determination of some potentially hazardous trace elements, such as Cd, Cu, Ni and Pb at low concentration in PM2.5 atmospheric aerosol particles. Therefore, a method has been developed for the determination of these elements in atmospheric aerosol particles using high-resolution continuum source graphite furnace ato
Background: Studies have shown that lifestyle interventions are effective in preventing or delaying the onset of type 2 diabetes in high-risk patients. However, research on the effectiveness of lifestyle interventions in high-risk immigrant populations with different cultural and socioeconomic backgrounds is scarce. The aim was to design a culturally adapted lifestyle intervention for an immigrant
Background: Up to half the residents of nursing homes for the elderly have asymptomatic bacteriuria (ABU), which should not be treated with antibiotics. A complementary test to discriminate between symptomatic urinary tract infections (UTI) and ABU is needed, as diagnostic uncertainty is likely to generate significant antibiotic overtreatment. Previous studies indicate that Interleukin-6 (IL-6) in
Objective: To determine the validity of 15 standardized instruments frequently used to measure the outcome of chronic arthritis treatment. Methods: Analyses were performed on data collected at a rehabilitation programme (n=216). The outcome measures evaluated were health-related quality of life, global health, pain, physical function and aerobic capacity. The instrument items were linked to the In
This paper discusses the results of a time-dynamic analysis of the possible effects of government and utility-sponsored energy-efficiency programs on electric energy use in Swedish commercial buildings. In the study, which includes efficient lighting, improvements in ventilation, commercial cooling and cooking, we use energy scenarios to analyse how policy measures can effect future energy demand.
Popular Abstract in Swedish Bakgrund Avsikten med denna studie har varit att värdera om det idag föreligger tecken som tyder på att utvecklingen av diagnostiska hjälpmedel och behandlingsmetoder vid cancer i bukspottkörteln har åtföljts av en förbättrad prognos, samt att värdera vilken roll rökning och magsårsoperation kan ha för uppkomsten av sjukdomen. Pancreascancer, cancer i bukspottkörteln, The objective of this thesis has been to assess whether there are indications suggesting that new methods for diagnosis and treatment of pancreatic carcinoma (PCa) has been followed by an improved prognosis, and to assess the possible role of smoking and gastric resection in the causation of the disease. Of the 1,200 new cases PCa diagnosed in Sweden yearly, the majority are older than 70 years,
The debate about post-2012 global climate governance has been framed largely by proponents and opponents of the policymaking process established by the United Nations Framework Convention on Climate Change (UNFCCC). In light of the proliferation of institutions governing some aspects of climate change, analysts have asked whether a centralized or a polycentric climate governance architecture will
This Thesis examines what possibilities Member States have to impose levies on CO2 emissions from motor vehicles in the light of EU indirect tax legislation and the Eurovignette Directive. In this Thesis, carbon tax on fuel and a CO2 differentiated road toll are studied as levying options. Motor fuel is an excise good to which the harmonised EU excise duty system applies. Accordingly, the questi
Since 2011, LUNARC has aimed to provide an interactive HPC environment for its resource users. Several different architectures have been used, but since 2013, we have been using a remote desktop environment based on Cendio's ThinLinc [1] combined with a custom backend framework, GfxLauncher [2], supporting hardware-accelerated graphics applications and Jupyter Notebooks [3] submitted to the backen
Japan's January withdrawal of funding from the UN Committee on the Elimination of Discrimination against Women highlights its aversion to addressing gender equality issues at home. Despite externally presenting a commitment to progressive gender norms, a tension between Japan's international image and its domestic reality persists. Japan continues to rank low in major gender equality indexes as re
Purpose Children living with respiratory support rely on medical technology, either fully or partially, throughout the day to meet their breathing requirements. Although children and young people living with respiratory support at home undergo long-term treatments and make extensive use of health and social care services, there is a notable absence of comprehensive outcome data on this group. The
Accurate prediction of crack growth and strength in glued timber joints and components can be achieved by using cohesive laws in constitutive models. These laws represent the traction-separation relationship that measures the stress transmitted between crack faces in a cohesive zone, and can be obtained directly from experiments. However, studies on measuring the cohesive laws of wood adhesive bon
A search for a hypothetical heavy scalar particle, X, decaying into a singlet scalar particle, S, and a Standard Model Higgs boson, H, using 140 fb−1 of proton-proton collision data at the centre-of-mass energy of 13 TeV recorded with the ATLAS detector at the LHC is presented. The explored mass range is 300 ≤ mX ≤ 1000 GeV and 170 ≤ mS ≤ 500 GeV. The signature of this search is one or two leptons
Research on climate change obstruction has often focused on what has been called the Climate Change Countermovement, the CCCM. While the term originated from the social movements literature – acknowledging the movement-countermovement dynamics – it has in climate obstructionist research often been described as a relatively fixed entity connected to the vested interests of the fossil fuel industry
Thirty images with added simulated pathological lesions at two different dose levels (100% and 10% dose) were evaluated with the free-response forced error experiment by nine experienced radiologists. The simulated pathological lesions present in the images were classified according to four different parameters: the position within the lumbar spine, possibility to perform a symmetrical (left-right
