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Introduction: Pancreatic cancer is a highly lethal disease with a close association between incidence and mortality. First-line (FL) palliative chemotherapy prolongs survival and alleviates cancer-related symptoms. However, the survival benefit of second-line (SL) treatment is uncertain, as studies fail to consistently show prolonged survival for any given SL treatment, and in the absence of progn
Culture-expanded mesenchymal stromal cells (MSCs) are promising candidates for clinical cell-based therapies. MSC products are heterogeneous and we therefore investigated whether acoustophoresis, an ultrasound-based separation technology, could be used for the label-free enrichment of functionally different MSC populations. Acoustophoresis uses an ultrasonic standing wave in a microchannel which d
BACKGROUND: Highly increased risk of injuries has been noted around the time of cancer diagnosis. Whether there is a similar increase in risk around the diagnosis of cervical cancer and its precursor lesions was unknown.METHODS: We performed a cohort study including 3,016,307 Swedish women that participated in cervical screening during 2001 to 2012. We calculated the incidence rates (IR) of hospit
Inter-organisational projects depend on stakeholder interactions and joint decision-making to perform and continually adjust to variations. This paper examines the emergence of transformative resilience (i.e., dynamic project capabilities to pursue fundamentally new strategies and practices) when facing external disruptions. A process-orientated case study was conducted within a culturally diverse
In the present study, we apply deterministic chaos theory to investigate nonlinear dynamics in monthly precipitation at Mokpo, Korea, after wavelet decomposition. The wavelet transform is used not only for removal of noise but also for extraction of low and high frequency components in the data, representing low-dimensional dynamics. In order to determine an appropriate decomposition level for the
The UPCA for the first time establishes harmonized exceptions and limitations to the effects of granted patent rights. Previously these were the sole province of national law but a with a degree of similarity.This chapter briefly analyses the historical origin, legal nature and scope of Article 27 UPCA, the future harmonizing effect of UPCA patent limitations, followed by a discussion on each limi
Primär hyperparathyroidism, pHPT, är en relativt vanlig endokrinologisk sjukdom som karaktäriseras av förhöjd utsöndring av bisköldkörtelhormon, PTH, i förhållande till kalciumnivån i blodet. Sjukdomen är vanligast hos äldre och kvinnor, och orsakas oftast av en godartad tumör i en bisköldkörtel (80–85% av fallen) eller mer diffus förstoring av flera bisköldkörtlar. Bisköldkörtlarnas fysiologiska
SKA Construction phase we are now in a transition phase that hopefully will prepare us for the next challenge: start building the SKA. One of the targets of this period is to evaluate the suitability of the Taranta (proper Webjive) Suite for creating engineering User Interfaces (UIs). The Taranta suite is a framework that allows the fast creation of web UIs that directly communicate with TANGO dev
This article explores the use of sustainability criteria for biomass as a tool to promote and safeguard sustainability of this product. Much attention is paid to the issues that sustainability criteria for biomass should consider. Among them the priority for food supply and food security, the emission reduction of green house gases (GHG) through the whole production chain, the preservation of area
Background: There are several risk factors for the colonisation, infection and spreading of antibiotic resistant bacteria among elderly residents of nursing homes. An updated estimate of the native prevalence of antimicrobial resistance in uropathogens among Swedish nursing home residents is needed. Methods: Urine specimens were collected for culture and antimicrobial susceptibility testing agains
The aim of this thesis is to critically examine how ethical principles are conceptualized and applied in educational contexts, focusing on the intersection of early childhood education and education for sustainable development. Its contribution to educational research in general, and to philosophy of education in particular, is to; first, discuss the presumed relation between ethical principles an
Lojalitetsplikten, även benämnd lojalitetsprincipen, är en allmän rättsprincip i svensk avtalsrätt som innebär en plikt att beakta motpartens intressen utö-ver avtalets reglerade utfästelser. Definitioner av lojalitetsplikten ger inte mycket ledning för hur den ska förstås. Vad som därför är relevant är hur begreppet används. Generellt vilar lojalitetsplikten på outtalade förpliktelser som utgår fThe duty of loyalty, also known as the principle of loyalty, is regarded as a general principle of law in Swedish contract law. It implies a duty to observe the interests of the counter-party beyond the regulated obligations in the contract. Different definitions of the duty of loyalty do not give much advice as of how it should be interpreted. Therefore, what is relevant is how the principle is b
The liberty of religion is not easy to define or regulate. It is closely connected to other liberties and rights. Starting from individual liberty, the consequence will be a right to religion or from religion, the right to change religion or confession, and the right to transition from religion to no religion, or from no religion to religion. It is obvious that the state, the religious denominatio
Wilms' tumor gene 1 (WT1) is a transcription factor involved in developmental processes. In adult hematopoiesis, only a small portion of early progenitor cells express WT1, whereas most leukemias show persistently high levels, suggesting an oncogenic role. We have previously characterized oncogenic BCR/ABL1 tyrosine kinase signaling pathways for increased WT1 expression. In this study, we show tha
Background: People with Intellectual disabilities (ID) have more healthcare utilization, especially unplanned inpatient care. One reason could be too early hospital discharges, resulting in readmissions. This is an important aspect of quality of care that has not been thoroughly assessed among people with ID. Aim: To investigate readmission to hospital within 30 days among people with ID compared
Background People with serious respiratory illness frequently have a high symptom burden and may be prescribed supplemental oxygen therapy with the aims of reducing the severity of breathlessness and improving health-related quality of life (HRQoL). This systematic review and meta-analysis aimed to assess the effectiveness of oxygen therapy versus no oxygen on 1) breathlessness, 2) HRQoL and 3) ad
The post-2015 developmental agenda and the SDGs have been formulated to advance holistic global progress and enable the adoption of quantitative targets for all countries by recognizing their respective national realities and capacities. This research examines how global ambitions can guide national policy formulation by selecting the Italian Republic and the People's Republic of Bangladesh as mod
BACKGROUND: Breast cancer (BC) is the most common type of cancer in women worldwide. Post-treatment, patients suffer from side effects and have various rehabilitation needs, which means that individualization is fundamental for optimal rehabilitation. This systematic review (SR) of SRs aims to evaluate the current evidence on rehabilitation interventions in female patients following BC treatment.M
