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Surveys of prescribing patterns in both hospitals and primary care have usually shown delays in translating the evidence from clinical trials of pharmacological agents into clinical practice, thereby denying patients with heart failure (HF) the benefits of drug treatments proven to improve well-being and prolong life. This may be due to unfamiliarity with the evidence-base for these therapies, the

Scand J Caring Sci; 2011 Individual placement and support - a model to get employed for people with mental illness - the first Swedish report of outcomes Lack of participation in the open labour market is highly prevalent for people with a mental illness across countries, and the proportion of people who get some kind of sickness benefit because of mental illness is steadily growing in Europe. Voc

We propose a method for dividing large regions into biogeographical sub-regions based mainly on natural disturbance regime, forest history and potential tree species distribution. This subdivision could be used as a guide when designing conservational strategies and management plans for landscapes and protected areas. At present, conservational strategies and management of valuable areas on the on

The World Health Organization (WHO) tuberculosis (TB) symptom screening instrument (WHO-TB) can identify human immunodeficiency virus (HIV)-infected individuals at low risk of tuberculosis (TB); however, many patients report WHO-TB symptoms and require further TB investigations. We hypothesized that further clinical scoring could classify subjects with a positive WHO-TB screening result (WHO-TB(+)

Background and purpose Tibial osteotomy by the hemicallotasis technique (HCO) requires strong pin fixation. We compared pin fixation in HCO using a new self-drilling XCaliber pin (Orthofix) with optimized thread and tip design, with the commonly used standard pin (Orthofix). Patients and methods 50 patients, mean age 51 (35-66) years, to be treated by HCO were randomized to standard pins or XCalib

Popular Abstract in Swedish Denna avhandling fokuserar på frågan om försoning och (sökandet efter) värdegemenskap. Värden sätts in i ett större sammanhang, i ett så kallat "moraliskt landskap". Avhandlingen beskriver först olika hinder för försoning och dialog i Nordirland och Sydafrika i form av följande komponenter av det moraliska landskapet: -Erfarenheter (av trauma, segregation, ojämlikhet) -In Northern Ireland and South Africa obstacles to reconciliation were found in these elements of a “moral landscape”: – Experiences of trauma, separation and inequalities, – Divergent views of the conflict and of “the other”, – Opposing identifications and loyalties, – Norms for interaction, – Contestant interpretations of values such as “peace” and “justice”. This study describes how these obstac

With the recent advances towards modern Ion Beam Analysis (IBA), going from one- or few-parameter detector systems to multi-parameter systems, it has been necessary to expand and replace the more than twenty years old CAMAC based system. A new VME multi-parameter (presently up to 200 channels) data acquisition and control system has been developed and implemented at the Lund Ion Beam Analysis Faci

The transcription factor STAT3 is a potential target for the treatment of castration-resistant prostate cancer. Galiellalactone (1), a direct inhibitor of STAT3, prevents the transcription of STAT3 regulated genes. In this study we characterized 6 (GPA512, Johansson, M.; Sterner, O. Patent WO 2015/132396 A1, 2015), a prodrug of 1. In vitro studies showed that 6 is rapidly converted to 1 in plasma

Introduction: The aim of this study is to report the current status of ovarian tissue cryopreservation among alternatives for fertility preservation in the Nordic countries. Material and methods: A questionnaire was sent to 14 Nordic academic reproductive centers with established fertility preservation programs. It covered fertility preservation cases performed up to December 2014, standard proced

The current work focus on the overlay method proposed by Austrell concerning frequency dependence of the dynamic modulus and loss angle that is known to increase more with frequency for small amplitudes than for large amplitudes. The original version of the overlay method yields no difference in frequency dependence with respect to different load amplitudes. However, if the elements in the viscoel

In osteopetrosis, osteoclast dysfunction can lead to deafness, blindness, bone marrow failure, and death. Hematopoietic cell transplantation (HCT) is currently the only curative treatment, but outcome remains disappointing. Although a rapid progression toward HCT is detrimental to prevent further progress of disease manifestations, 70% of cases lack an HLA-matched sibling and require alternative s

Efforts are made in radiographic examinations to obtain the best image quality with the lowest possible absorbed dose to the patient. In dental radiography, the absorbed dose to patients is very low, but exposures are relatively frequent. It has been suggested that frequent low-dose exposures can pose a risk for development of future cancer. It has previously been reported that there was no signif

A search is performed for collimated muon pairs displaced from the primary vertex produced in the decay of long-lived neutral particles in proton-proton collisions at root s = 7 TeV centre-of-mass energy, with the ATLAS detector at the LHC. In a 1.9 fb(-1) event sample collected during 2011, the observed data are consistent with the Standard Model background expectations. Limits on the product of

Pheromone-based monitoring could be a very efficient method to assess the conservation status of rare and elusive insect species, but there are still few studies for which pheromone traps have been used to obtain information on presence, abundance, phenology and movements of such insects. We performed a mark-recapture study of two threatened saproxylic beetles, Osmoderma eremita (Scarabaeidae) and

Phosphatidylinositol-5-phosphate (PtdIns5P) 4-kinase beta (PIP4K2B) directly regulates the levels of two important phosphoinositide second messengers, PtdIns5P and phosphatidylinositol-(4,5)-bisphosphate [PtdIns(4,5)P-2]. PIP4K2B has been linked to the regulation of gene transcription, to TP53 and AKT activation, and to the regulation of cellular reactive oxygen accumulation. However, its role in

Background. In metastatic colorectal cancer, mutation testing for KRAS exon 2 is widely implemented to select patients with wild-type tumors for treatment with the monocloncal anti-EGFR antibodies cetuximab and panitumumab. The added predictive value of additional biomarkers in the RAS-RAF-MAPK and PI3K-AKT-mTOR pathways in colorectal cancer is uncertain, which led us to systematically review the

The southern Peruvian coastal desert around Palpa, southern Peru (14.5 degrees S) is currently characterized by hyper-arid conditions. However, the presence of two species of molluscs (Scutalus, Pupoides) and desert-loess deposits indicates the past development of semi-desert and grassland ecosystems caused by a displacement of the eastern desert margin due to hydrological changes. Radiocarbon dat

Very high levels of ambient particulate matter (PM) are frequently encountered in the north of Italy and air quality limits are regularly exceeded. To obtain quantitative information on the pollution sources and to gain understanding of the dynamics of pollution episodes in this populated area PM10 and/or PM2.5 samples were collected daily at nine urban to regional sites distributed over the centr