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PURPOSE: We performed an exploratory analysis of prostate cancer-related pain and fatigue on health-related quality of life in patients with metastatic castration-sensitive prostate cancer receiving apalutamide (240 mg/day) or placebo, with continuous androgen deprivation therapy (ADT), in the phase 3, randomized, double-blind, placebo controlled TITAN trial (NCT02489318). MATERIALS AND METHODS: P
Introduction: The purpose of this study was to investigate neurological disorder as a risk factor for dislocation following arthroplasty for acute hip fractures. We also analysed medical and surgical adverse events (AE), readmission, reoperation, revision, and mortality as secondary outcomes. Methods: A longitudinal cohort study using prospectively collected and aggregated data from the Swedish Hi
A chemiluminescent microformat enzyme linked immune sorbent assay (ELISA) has been optimized for the simultaneous determination of multiple 2,4-dichlorophenoxyacetic acid (2,4-D) samples. The competitive immunoassay employed a 2,4-D-BSA conjugate, anti-2,4-D monoclonal antibodies and alkaline phosphatase (AP) labelled anti-mouse IgG. The bound AP conjugate was determined by quantitating the chemil
A longitudinal study examined the association between interpersonal goals (selfimage and compassionate goals) and depression, anxiety, and stress symptoms. We propose that having self-image goals (trying to create and manage a positive image) may lead to psychological distress, while genuinely taking others' needs into account and caring for their welfare (compassionate goals) may promote psycholo
Background: The increase of the aging population is a challenge to society, as age is related to dependence. Injuries such as hip fractures cause morbidity, loss of independent life, and mortal-ity. The purpose of this protocol is to describe a randomized control trial, with three intervention arms, aiming at investigating if there are any differences in outcomes after hip fracture between differe
Background: Concern has been raised that the COVID-19 pandemic and consequent social distancing measures may increase neuropsychiatric symptoms in people with dementia. Thus, we developed and delivered an e-learning training course to professional caregivers on using a web-based tool for psychosocial interventions for people with dementia. Objective: The aim of our study was to evaluate the feasib
Background: While recommendations for the optimal distribution of surgical services in high-income countries (HICs) exist, it is unclear how these translate to resource-limited settings. Given the significant shortage and maldistribution of surgical workforce and infrastructure in many low- and middle-income countries (LMICs), the optimal role of decentralization versus regionalization (centraliza
Background: Uncomplicated cystitis is one of the most common reasons for antibiotic treatment in otherwise healthy women. Nationwide studies on antibiotic treatment for this infection and in relation to factors beyond the infection itself have hitherto not been available. Methods: This was a nationwide open cohort study consisting of 352,507 women aged 15–50 years with uncomplicated cystitis (2006
Objective: To assess the proportion of participants reconsidering their willingness to undergo surgery after 3 and 12 months. Secondary aims were to analyze and compare the characteristics of individuals willing and unwilling to undergo joint surgery for osteoarthritis (OA) before a first-line intervention, and to study the association between pain intensity, walking difficulties, self-efficacy, a
Dysfunctional water, sanitation and hygiene (WaSH) systems are mainly determined by poor water governance, exacerbating inequalities and poverty. Multi-stakeholder partnerships provide an approach to more flexible and adaptive governance to explore these problems. In this article, national commitments made to improve WaSH, made through the Sanitation and Water for All (SWA) partnership’s Mutual Ac
Increasing energy efficiency within the industrial sector is one of the main approaches in order to reduce global greenhouse gas emissions. The production and processing of aluminium is energy and greenhouse gas intensive. To make well‐founded decisions regarding energy efficiency and greenhouse gas mitigating investments, it is necessary to have relevant key performance indicators and information
Correlations of nighttime atmospheric methane (CH4) and 222radon (222Rn) observations in Heidelberg, Germany, were evaluated with the radon tracer method (RTM) to estimate the trend of annual nocturnal CH4 emissions from 1996-2020 in the footprint of the station. After an initial 30ĝ€¯% decrease in emissions from 1996 to 2004, there was no further systematic trend but small inter-annual variations
A search is performed for a long-lived particle decaying into a final state that includes a pair of muons of opposite-sign electric charge, using proton-proton collision data collected at s=13 TeV by the ATLAS detector at the Large Hadron Collider corresponding to an integrated luminosity of 32.9 fb-1. No significant excess over the Standard Model expectation is observed. Limits at 95% confidence
It is normally assumed that induced transitions, by e.g. hyperfine, magnetic field or spin interaction, arise due to mixing in the upper levels. In this paper we discuss an example when mixing in the lower levels through an externally applied magnetic field gives rise to a magnetic field induced transition. We discuss the theory for such a transition and give an example from Fe X, which is relevan
Introduction: It remains unclear whether offering psychiatric patients their preferred treatment influences outcomes at the symptom level. Objective: To assess whether offering patients with Panic Disorder with/without Agoraphobia (PD/A) a choice between two psychotherapies yields superior outcomes to random assignment. Methods: In a doubly randomised, controlled preference trial (DRCPT), 221 adul
IntroductionMulti‐component T2 mapping using a gradient‐ and spin‐echo (GraSE) acquisition has become standard for myelin water imaging at 3 T. Higher magnetic field strengths promise signal‐to‐noise ratio benefits but face specific absorption rate limits and shortened T2 times. This study investigates compartmental T2 times in vivo and addresses advantages and challenges of multi‐component T2 map
We propose a multistep approach for representing and classifying tree-like structures in medical images. Tree-like structures are frequently encountered in biomedical contexts; examples are the bronchial system, the vascular topology, and the breast ductal network. We use tree encoding techniques, such as the depth-first string encoding and the Prüfer encoding, to obtain a symbolic string represen
