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Idag finns det många olika sätt att avbilda människokroppens inre. Två av de vanligaste metoderna som används idag är magnetresonans (MR) och datortomografi (CT). MR använder sig av starka magnetfält och radiovågor för att skapa snittbilder av kroppen, medan CT använder sig av röntgenstrålar. Båda kamerorna har sina fördelar och nackdelar. MR ger bättre vävnadskontrast, det vill säga det är lättarIntroduction MRI provides better soft tissue contrast than CT and is an invaluable tool in the radiotherapy treatment process. The gold standard today is image fusion of MRI and CT data where targets and organs-at-risk are delineated on the MRI data and the dose calculation is performed on the CT data. It is appealing to exclude CT from the process in order to reduce cost and time and to eliminate

The ultramafic-mafic layered igneous Molopo Farms Complex straddles the border between South Africa and Botswana. Younger cover obscures this igneous complex and its country rocks, which are generally assigned to the Paleoproterozoic Transvaal Supergroup. The area intruded by the complex is characterized by abutting and contrasting successions of the upper Transvaal Supergroup (i.e., the Pretoria

BACKGROUND Advanced Therapy Medicinal Products (ATMPs) for human use have advanced globally with the rapid adoption of Chimeric Antigen Receptor T-cell (CAR-T) therapies in haemato-oncology. CAR-T cell therapy and ATMPs have unique, significant acute and chronic toxicities, and appropriate patient care is crucial. Significant challenges, including the need for nurse education and training, accompa

Eighteen lichen species, one lichenicolous and two allied fungi are reported for the first time for Latvia (Europe). Bryoria smithii, Heterodermia speciosa, Phaeophyscia pusilloides and Ramalina europaea are new records for the Baltic countries. Comments on habitats and substrates of new records are provided.

Fibrinogen can support host antimicrobial containment/clearance mechanisms, yet selected pathogens appear to benefit from host procoagulants to drive bacterial virulence. Here, we explored the hypothesis that host fibrin(ogen), on balance, supports Staphylococcus aureus infection in the context of septicemia. Survival studies following intravenous infection in control and fibrinogen-deficient mice

Aims Glucagon-like peptide-1 receptor agonists (GLP-1 RAs) stimulate the incretin system and lower glycaemic parameters in type 2 diabetes mellitus (T2DM). This analysis of clinical studies of up to 3 years evaluated the safety of albiglutide, a GLP-1 RA, in people with T2DM. Methods Integrated safety analysis included seven phase-3 T2DM studies of albiglutide compared with placebo and/or active c

Satellite remote sensing of plant phenology provides an important indicator of climate change. However, start of the growing season (SOS) estimates in Northern Hemisphere boreal forest areas are known to be challenged by the presence of seasonal snow cover and limited seasonality in the greenness signal for evergreen needleleaf forests, which can both bias and impede trend estimates of SOS. The ne

Social desirability may cause spurious relations in self-rating measures. The present study sought to disentangle socially desirable responding and content in the relation between measures of personality traits and well-being. Social desirability was operationalized as the evaluative factor (the tendency to react to evaluative content in questionnaire items). We collected self- and peer-ratings of

During the course of the late nineteenth and early twentieth centuries, conditions for life in the city changed drastically. Investments in infrastructure, health and education coincided with economic growth, urbanisation and mortality decline. This dissertation uses newly available macro- and micro-level data to examine the consequences and mechanisms of an important investment in cities: the bui

Establishing a solid chronological framework for Arctic marine sediments is a critical first step towards glacial and palaeoceanographic reconstructions. However, this has historically been more challenging than elsewhere in the world, and often results in core chronologies and subsequent paleoenvironmental reconstructions being questioned and overturned. Optically stimulated luminescence (OSL) da

The deactivation of a diesel SCR (Selective Catalytic Reduction) catalyst by impregnation with CaSO4 was studied. The loss in activity after 2729 h of use on the engine was lower than when deactivated by impregnation. This was the case even if the amount of Ca in the catalyst was high after use on the engine. In the used catalyst a surface layer of CaSO4 was built up on the monolith during use. Th

Osteoarthritis is a harmful joint disease but prediction of disease progression is problematic. Currently, there is only one modeling framework which can be applied to predict the progression of knee osteoarthritis but it only considers degenerative changes in the collagen fibril network. Here, we have developed the framework further by considering all of the major tissue changes (proteoglycan con

With improvements in cancer treatment and supportive care, a growing population of survivors of childhood cancer at risk for significant and potentially life-threatening late effects has been identified. To provide a current snapshot of the models of care from countries with varying levels of resources and health care systems, stakeholders in childhood cancer survivorship clinical care and researc

Human type 1 diabetes mellitus (T1DM) arises through autoimmune destruction of pancreatic β cells and is modeled in many respects by the lymphopenic and spontaneously diabetic BioBreeding (BB) DRlyp-lyp rat Previously, preonset expression profiling of whole DRlyp-lyp pancreatic lymph nodes (PLN) revealed innate immune activity, specifically that of mast cells and eosinophils. Furthermore, we obser

The palaeoproterozoic Northwestern region of the Ukrainian shield hosts two compositional types of mafic dykes and associated magmatism that intruded at c. 1800–1760 Ma: (1) high-Ni dolerite dykes and layered intrusions of tholeiitic affinity and (2) high-Ti dolerite dykes of jotunitic affinity associated with anorthosite–mangerite–charnockite–granite (AMCG) suites. The jotunitic dykes represent i

Purpose: To assess the psychometric properties of a Swedish version of the Posttraumatic Diagnostic Scale (PDS); to investigate the prevalence of traumatic experiences, trauma types and posttraumatic stress disorder (PTSD) in a sample of patients seeking treatment for chronic pain; and to examine how indices of pain-related functioning vary with a history of traumatic exposure and PTSD diagnostic

The sputter deposition and the growth of thin copper films on float glass substrates are in situ studied using grazing incidence, reflection mode X-ray absorption fine structure spectroscopy with subsecond time resolution. The experimental data are compared with model calculations, assuming the presence of crystalline, face-centered cubic metallic Cu nanostructures. From a detailed analysis of the

The reaction of perbenzylated (±)-myo-inositol 1,2-bis- and 1,2,6-tris-phosphites with benzyl bromoacetate, followed by catalytic (Pd/C) hydrogenolysis affords (±)-myo-inositol 1,2-bis- and 1,2,6-tris(carboxymethylphosphonate). The same procedure is used for the synthesis methyl α-D-mannopyranoside 2,3,4-tris(carboxymethylphosphonate).