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Background: Currently, the TNM classification of malignant tumours based on clinicopathological staging remains the standard for colorectal cancer (CRC) prognostication. Recently, we identified the mitochondrial oxidative phosphorylation chain as a consistently overrepresented category in the published gene expression profiling (GEP) studies on CRC prognosis. Methods: We evaluated associations of
The dynamics and consequences of host-parasite coevolution depend on the nature of host genotype-by-parasite genotype interactions (G × G) for host and parasite fitness. G × G with crossing reaction norms can yield cyclic dynamics of allele frequencies ("Red Queen" dynamics) while G × G where the variance among host genotypes differs between parasite genotypes results in selective sweeps ("arms ra
A search for the production of single top-quarks via flavour-changing neutral-currents is presented. Data collected with the ATLAS detector at a centre-of-mass energy of root s = 7 TeV, corresponding to an integrated luminosity of 2.05 fb(-1), are used. Candidate events with a semileptonic top-quark decay signature are classified as signal- or background-like events by using several kinematic vari
The New Zealand emissions trading scheme (ETS) wasintroduced by legislation in 2008. The legislated objectives asstated in section 3 of the Climate Change Response Act 2002are to ‘support and encourage global efforts to reduce theemission of greenhouse gases by (i) assisting New Zealandto meet its international obligations under the [UNFCCC].
Selection on proteins is typically measured with the assumption that each protein acts independently. However, selection more likely acts at higher levels of biological organization, requiring an integrative view of protein function. Here, we built a kinetic model for de novo pyrimidine biosynthesis in the yeast Saccharomyces cerevisiae to relate pathway function to selective pressures on individu
A neutron transport system for the planned imaging instrument ODIN at the future European Spallation Source (ESS) based on neutron optical components was designed and optimized. Different ways of prompt pulse suppression were studied. The spectral performance of the optimal neutron guide configuration is presented. In addition, the influence of the gaps in the guide system needed for the required
Self-diffusion in polymer solutions studied with pulsed-field gradient nuclear magnetic resonance (PFG NMR) is typically based either on a single self-diffusion coefficient, or a log-normal distribution of self-diffusion coefficients, or in some cases mixtures of these. Experimental data on polyethylene glycol (PEG) solutions and simulations were used to compare a model based on a gamma distributi
The Intermediate Data Structure (IDS) is a standardised database structure for longitudinal historical databases. Such a common structure facilitates data sharing and comparative research. In this study, we propose an extended version of IDS, named IDS-Geo, that also includes geographic data. The geographic data that will be stored in IDS-Geo are primarily buildings and/or property units, and the
A new class of chiral non-racemic gamma- and delta-amino alcohols based on bicyclo[2.2.1]heptane and bicyclo[2.2.2]octane have been synthesized and used as catalysts in the asymmetric diethylzinc addition to benzaldehyde. (C) 2008 Elsevier Ltd. All rights reserved.
Systems based on bag-of-words models from image features collected at maxima of sparse interest point operators have been used successfully for both computer visual object and action recognition tasks. While the sparse, interest-point based approach to recognition is not inconsistent with visual processing in biological systems that operate in 'saccade and fixate' regimes, the methodology and emph
Background: Following the 2007 precise measurements of monopole strengths in tin isotopes, there has been a continuous theoretical effort to obtain a precise description of the experimental results. Up to now, there is no satisfactory explanation of why the tin nuclei appear to be significantly softer than Pb-208. Purpose: We determine the influence of finite-range and separable pairing interactio
Essay rereading Haraways Cyborg Manifesto
Background In many scientific domains, it is becoming increasingly common to collect high-dimensional data sets, often with an exploratory aim, to generate new and relevant hypotheses. The exploratory perspective often makes statistically guided visualization methods, such as Principal Component Analysis (PCA), the methods of choice. However, the clarity of the obtained visualizations, and thereby
We consider simple approximations of variances and covariances for order statistics from the standard extreme value distribution. Exact values and simulation results of the variances and covariances for certain sample sizes are used to determine the validity of the suggested approximations.
The tawny pipit (Anthus campestris) is a migrant bird adapted to dry, sandy habitats. In southern Sweden, land use changes have resulted in a reduction of suitable areas, affecting the birds’ population size. The SandLife Project was created with the goal to restore those sandy grasslands and improve local conditions to stimulate the recovery of biodiversity. In order to compare the current and th
This thesis is a case study on the family reunification procedure for refugees in Denmark, in the context of an increasingly restrictive environment. It sought to find out how structural facets of Danish immigration law interact with and influence the practices of navigating a family reunification process, for people with a refugee background. Two phases of semi-structured interviews were conducte
Since the introduction of Edison’s lightbulb over one-hundred years ago, humanity has struggled to keep up with electrification for all. With global attention now aimed at sustainable energy production, the struggle becomes more complex by not only obliging energy access, but access to clean energy. The concept of microgrids has been promising for filling in the demand, but not quickly enough to m
Neonicotinoid insecticides are agonists to nicotinic acetylcholine receptors (nAChRs) in the brains of insects. At sub-lethal doses these chemicals cause behavioral abnormalities in several bee species, reducing overall fitness. nAChRs expressed in the optic lobes of insects bind neonicotinoids, thus may be involved in these behavioral changes. Here we attempted without success to visualize the pr
Surrogacy is a much-discussed issue in Spain since in 2017 the political party Ciudadanos proposed in parliament a law to legalize altruistic surrogacy. Since then, the main political parties have constructed a discourse on surrogacy, positioning themselves in favor of or against its legalization. Meanwhile, civil society has also mobilized and associations fighting for or against the legalization
