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Human immunodeficiency virus type 1 (HIV-1) rapidly evolves during disease progression. This study aimed to explore the intrahost diversity, evolutionary rate, molecular properties, and co-receptor tropism of HIV-1 in relation to disease progression in an occupational cohort of police officers from Guinea-Bissau, where the HIV-1 circulating recombinant form CRF02_AG predominated. The study partici
