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Pooling metabolomics data across studies is often desirable to increase the statistical power of the analysis. However, this can raise methodological challenges as several preanalytical and analytical factors could introduce differences in measured concentrations and variability between datasets. Specifically, different studies may use variable sample types (e.g., serum versus plasma) collected, t

Building barriers are compartmentation elements in buildings that limit the passage of fire and smoke to adjacent spaces. They are key elements in the overall response of a building in a fire. The adequate fire response of building barriers is usually assessed by the fulfilment of standardized resistance to fire tests. However, building fire barriers might be exposed to very different fire scenari

The growing menace of global warming and restrictions on access to water in each region is a huge threat to global hydrological sustainability. Hence, the perspective at which hydrological studies are currently being carried out across the world to quantify and understand the water cycle modeling requires a further boost. In the past few decades, the theoretical understanding of machine learning (

The valorisation of lignin is being increasingly recognised to improve the economics of pulp and paper making mills. In the present study, an integrated lignin–glycerol valorisation strategy is introduced with an overarching aim for enhancing the process value chains. LignoBoost kraft lignin was subjected to base-catalysed depolymerisation using glycerol as a co-solvent. The generated bio-oil was

Parkinson’s disease (PD) is one of the most common neurodegenerative disorders. The motor and non-motor symptoms of PD lead to a number of consequences in everyday life for persons with PD (PwPD). PwPD continuously need to adapt to their new life situation and despite medical treatment, the impact of PD on everyday life is inevitable and can lead to a lower level of life satisfaction (LS). LS is a

We suggest the hybrid model for the description of the dipole spreading widths, in which the strength function is built on the one-phonon strength distribution folded with the energy-dependent Lorentzian. Its energy dependence is brought about by (i) the energy-dependent smearing parameter and (ii) the energy-dependent shift of the one-phonon states. These variables are estimated by means of the t

We present Bioconda (https://bioconda.github.io), a distribution of bioinformatics software for the lightweight, multi-platform and language-agnostic package manager Conda. Currently, Bioconda offers a collection of over 3000 software packages, which is continuously maintained, updated, and extended by a growing global community of more than 200 contributors. Bioconda improves analysis reproducibi

This Movement Disorder Society Genetic mutation database Systematic Review focuses on monogenic atypical parkinsonism with mutations in the ATP13A2, DCTN1, DNAJC6, FBXO7, SYNJ1, and VPS13C genes. We screened 673 citations and extracted genotypic and phenotypic data for 140 patients (73 families) from 77 publications. In an exploratory fashion, we applied an automated classification procedure via a

Background: Lead-time is defined as the time by which screening advances the diagnosis compared with absence of screening. A sufficiently long lead-time needs to be achieved so that cancer can be detected while still curable. A very short lead-time may indicate poor sensitivity of the screening test, while a very long lead-time suggests overdiagnosis. Material and methods: In the first screening r

Placental malaria infection is mediated by the binding of the malarial VAR2CSA protein to the placental glycosaminoglycan, chondroitin sulfate. Recombinant subfragments of VAR2CSA (rVAR2) have also been shown to bind specifically and with high affinity to cancer cells and tissues, suggesting the presence of a shared type of oncofetal chondroitin sulfate (ofCS) in the placenta and in tumors. Howeve

The Swedish Neutron Scattering Society (SNSS) is an organization open to all those associated with Sweden who are using, or interested in the use of, neutron scattering techniques. Currently, the SNSS has around 230 members distributed all over Sweden. The SNSS is a member of the European Neutron Scattering Association (ENSA) [1], which represents the majority of the national neutron scattering so

This work presents the first data from a calculation engine for synchrotron Microbeam Radiation Therapy (MRT) implemented in the EclipseTM Treatment Planning System from Varian Medical Services. The calculation engine constitutes a simple pencil beam algorithm estimating ‘peak’ dose and of Monte Carlo simulated Peak Valley Dose Ratios (PVDRs) that are used to obtain ‘valley’ dose. The aim of this

This thesis explores the under-recognised yet symptomatic visual motif of two women, a recurring theme within a vast array of pictorial examples. Its primary objective is to construct a theoretical and methodological framework capable of comprehending the multiplicity of images in the form of an image collection: The Atlas of Two Women. This inquiry primarily draws on Walter Benjamin’s concept of

The number of devices connected to the Internet is rapidly increasing. Especially the number of Internet of Things devices. These devices contain software which, like any other software, needs to be updated. With the great amount of devices to update, this calls for a manageable updating solution which does not depend on user interaction. In this thesis we present a solution to dynamically update

The aim of this study was to optimize a function starch-ethyl cellulose film for targeting the therapeutically active substance to the colon in the disease state for patients suffering from inflammatory bowel diseases. This study includes: • The preparation of the polymeric films and the investigation of the characterization (for example mechanical properties, water uptake, dry mass loss, and mic