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Targeting the androgen receptor (AR) pathway prolongs survival in patients with prostate cancer, but resistance rapidly develops. Understanding this resistance is confounded by a lack of noninvasive means to assess AR activity in vivo. We report intracellular accumulation of a secreted antigen-targeted antibody (SATA) that can be used to characterize disease, guide therapy, and monitor response. A
Since even before being sworn in as president of France in 2017, Emmanuel Macron has been a prominent advocate of the European Union in a time of growing Euroscepticism. Throughout his presidency, France, Europe, and the world have experienced political upheaval such as the covid-19 pandemic, Brexit, and the Russian invasion of Ukraine with various consequences. The aim of this thesis is to analys
This paper explores the potential of corpus data to account for language users’ mental representations of a high-frequency item that is prone to phonetic reduction. We present an analysis of the realisations of semi-modal have to in spoken American English, which is a candidate for to-contraction (compare wanna and gotta) but has no clearly established contracted form. The study therefore focusses
Authentication codes that permit arbitration are codes that unconditionally protect against deceptions from the outsiders and additionally also protect against some forms of deceptions from the insiders. Simmons introduced this authentication model and he also showed a way of constructing such codes, called the Cartesian product construction. We present a general way of constructing such codes and
While foreign direct investments (FDI) are promoted as a vehicle for economic development their environmental consequences are less established. This study tests the hypotheses that 1) FDI led to environmental degradation in form of increased greenhouse gas emissions during Sub-Saharan Africa´s recent growth spurt but that 2) this impact was felt to a lesser extent in countries with a higher quali
While foreign direct investments (FDI) are promoted as a vehicle for economic development their environmental consequences are less estab-lished. This study tests the hypotheses that 1) FDI led to environmental deg-radation in form of increased greenhouse gas emissions during Sub-Saharan Africa´s recent growth spurt but that 2) this impact was felt to a lesser extent in countries with a higher qua
Sexually selected traits are often condition-dependent and are expected to be affected by genome-wide distributed deleterious mutations and inbreeding. However, sexual selection is a powerful selective force that can counteract inbreeding through purging of deleterious mutations. Inbreeding and purging of the inbreeding load for sexually selected traits has rarely been studied across natural popul
Human cytomegalovirus (HCMV)-infected cells express a virus-encoded receptor that is able to bind the Fc part of IGG: Some basic binding properties of this Fc receptor (FcR) have been examined. The affinity constant (K(a)) for human IgG Fc fragment in its interaction with acetone-fixed, HCMV-infected human embryonic lung fibroblasts was estimated to be around 2 x 10(8) M(-1) and the number of bind
Objectives. To study the relationship between clinical manifestations in systemic lupus erythematosus (SLE) with polymorphisms in suggested susceptibility genes encoding Fc gamma RIIa, Fc gamma RIIIa, Fc gamma RIIIb, CRP and IL-1Ra. Methods. Genetic polymorphisms were analysed in 323 unrelated SLE patients and 200 healthy blood donors. The genotype frequencies were compared between clinical subset
This dissertation is about the view of writing. One of the intentions of the study is to analyse different notions of writing that become manifest in media debates about student writing. Another intention is to analyse conceptions of writing in curricula and course plans for upper secondary school in Sweden from 1970 to 2011. Drawing from theories of critical discourse analysis, the study aimThis dissertation is about the view of writing. One of the intentions of the study is to analyse different notions of writing that become manifest in media debates about student writing. Another intention is to analyse conceptions of writing in curricula and course plans for upper secondary school in Sweden from 1970 to 2011. Drawing from theories of critical discourse analysis, the study aim
This study aims to research the effect the conflict between Russia and Ukraine have had on third party countries' economic growth. Employing an econometric model with inspiration from previous research and Solow's growth model with augmentation to include human capital. The research spans the period from 1993 to 2022. The third party countries are categorized into four different groups bas
https://www.historiskamuseet.lu.se/english - 2026-07-01
Lancefield extracts of 19 types of group A streptococci as well as one group C and one group G strain were examined for agglutination of human red cells coated with various anti-Rh antibodies. Fourteen extracts agglutinated one or more of the coated cell samples, while five did not. The agglutination was inhibited by Fc but not by Fab fragments of human IgG. After mouse passages, three of the non-
BACKGROUND: Effector functions of IgG antibodies (Abs) are regulated by their Fc N-glycosylation pattern. IgG Fc glycans that lack galactose and terminal sialic acid residues correlate with the severity of inflammatory (auto)immune disorders and have also been linked to the protection against viral infection and discussed in the context of vaccine-induced protection. In contrast, sialylated IgG Ab
The major histocompatibility complex (MHC) is central in adaptive immunity, with the highly polymorphic MHC genes encoding antigen-presenting molecules. Two MHC class II (MHC-II) loci, DA1 and DA2, predate the radiation of extant birds and persist throughout much of the avian phylogeny. Within each locus, the MHC-II molecules are encoded by A-genes (DAA) and B-genes (DAB), which are arranged in A–
