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Acute myeloid leukemia (AML) is initiated and propagated by leukemia stem cells (LSCs), a self-renewing population of leukemia cells responsible for therapy resistance. Hence, there is an urgent need to identify new therapeutic opportunities targeting LSCs. Here, we performed an in vivo CRISPR knockout screen to identify potential therapeutic targets by interrogating cell surface dependencies of L
Popular Abstract in Swedish Syftet med avhandlingen är att belysa det kvinnliga initiativet i den samhällsutveckling som accelererade kring slutet av 1800-talet och så småningom kom att leda fram till det moderna, demokratiska s k välfärdssamhället. Metoden är att i en livsverksbiografi lyfta fram en av tidens aktörer, nämligen professorskan Agda Montelius. Hon kan ses som en representant dels förThe purpose of this thesis is to shed light on the role of female initiative in the accelerating social developments of the late nineteenth century that were eventually to result in Sweden’s modern, democratic welfare state. The method is a biographical study that highlights one of the leading figures of the day, Agda Montelius. She may be seen as representative not only of those middle and upper
The murine embryonal stem (ES) cell virus (MESV) can express transgenes from the long terminal repeat (LTR) promoter/enhancer in undifferentiated ES cells, but expression is turned off upon differentiation to embryoid bodies (EBs) and hematopoietic cells in vitro. We examined whether a human immunodeficiency virus type 1-based lentivirus vector pseudotyped with the vesicular stomatitis virus G pro
The right to leave a country is enshrined in both international human rights law and its European counterpart. It is a right which is independent and does not require the individual exercising it to show that he or she is admissible in some other country. It is exercisable even in the absence of evidence of possible admission to a destination country. However, in Europe (and some other parts of th
BACKGROUND: : Inherited mutations in the CDKN2A tumor suppressor gene, which encodes the p16(INK4a) protein, and in the cyclin-dependent kinase 4 (CDK4) gene confer susceptibility to cutaneous malignant melanoma. We analyzed families with two or more cases of melanoma for germline mutations in CDKN2A and CDK4 to elucidate the contribution of these gene defects to familial malignant melanoma and to
Introduction: Preoperative chemotherapy in early breast cancer increases the rate of breast preservation and provides prognostic information. In the case of residual disease, a change in subtypes may be observed. Sensitive and reproducible biomarkers predicting treatment response early during the treatment course are needed in order to better exploit the potential benefit of an individualized preo
Breast tumors of the basal-like, hormone receptor-negative subtype remain an unmet clinical challenge, as there is high rate of recurrence and poor survival in patients following treatment. Coevolution of the malignant mammary epithelium and its underlying stroma instigates cancer-associated fibroblasts (CAFs) to support most, if not all, hallmarks of cancer progression. Here we delineate a previo
We characterize the selection function of RAdial Velocity Experiment (RAVE) using 2 Micron All Sky Survey (2MASS) as our underlying population, which we assume represents all stars that could have potentially been observed.We evaluate the completeness fraction as a function of position, magnitude and colour in two ways: first, on a field-by-field basis, and second, in equal-size areas on the sky.
Cytomegalovirus induces a chronic infection that in normal individuals is controlled by the immune system. In the case of humoral immunity, epitopes, in particular antigenic domain-1, in glycoprotein B have proven to be important for the induction of virus-neutralizing activity. Such antibodies can exert potent virus-neutralizing activity but can also block neutralizing antibodies from binding. Fu
The primary objective of this multicenter, multinational, epidemiological study is the identification of infectious agents, dietary factors, or other environmental exposures that are associated with increased risk of autoimmunity and type 1 diabetes mellitus (T1DM). Factors affecting specific phenotypic manifestations such as early age of onset or rate of progression or with protection from the de
Interleukin-1 (IL-1)-family cytokines are potent modulators of inflammation, coordinating a vast array of immunological responses across innate and adaptive immune systems. Dysregulated IL-1-family cytokine signaling, however, is involved in a multitude of adverse health effects, such as chronic inflammatory conditions, autoimmune diseases, and cancer. Within the IL-1 family of cytokines, six—IL-1
Chronic pruritus (CP) is frequent in general medicine and the most common complaint in general dermatology. The prevalence of CP is expected to rise in the future due to the ageing population. The clinical presentation, underlying aetiology and treatment strategy of CP are heterogeneous. Also, individual treatment aims and physical, psychic and economic burdens of patients might vary. Chronic prur
Purpose: Application of standardised and automated assessments of head computed tomography (CT) for neuroprognostication after out-of-hospital cardiac arrest. Methods: Prospective, international, multicentre, observational study within the Targeted Hypothermia versus Targeted Normothermia after out-of-hospital cardiac arrest (TTM2) trial. Routine CTs from adult unconscious patients obtained > 48 h
VI International Conference on Computational Methods for Coupled Problems in Science and Engineering COUPLED PROBLEMS 2015 B. Schrefler, E. Oñate and M. Papadrakakis(Eds) CONVERGENCE SPEED OF COUPLING ITERATIONS FOR THE UNSTEADY TRANSMISSION PROBLEM AZAHAR MONGE∗ AND PHILIPP BIRKEN∗ ∗Centre for Mathematical Sciences Lund University Box 118, 22100, Lund, Sweden e-mail: azahar.monge@na.lu.se, web p
https://www.maths.lu.se/fileadmin/maths/personal_staff/Philipp_Birken/coupled.pdf - 2026-07-10
År 2006 myntade Professor Juliet Stumpf vid Lewis and Clark Law School i Oregon i USA begreppet ”crimmigration”. När hon gjorde det, döpte hon också en juridisk utveckling som startade i mitten av 1980-talet i USA. Begreppet är en sammanslagning av orden ”criminal” och ”immigration” vilket är passande eftersom begreppet beskriver och uppmärksammar sammanslagningen av straffrätt och migrationsrätt.
\\server05\productn\J\JLE\40-4\JLE407.txt unknown Seq: 1 11-MAR-10 10:13 DEFINING THE LIMITS OF CORPORATE RESPONSIBILITIES AGAINST THE CONCEPT OF LEGAL POSITIVE OBLIGATIONS RADU MARES* I. INTRODUCTION . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 1158 R II. CORPORATE-SOCIAL-RESPONSIBILITY INSTRUMENTS AND LITERATURE . . . . . . . . . . . . . . . . . . . . . . . . .
https://rwi.lu.se/app/uploads/2012/06/2009-Defining-the-Limits-of-Corporate-Responsibilities.pdf - 2026-07-10
