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Vatten | LTH, Lunds Tekniska Högskola Hoppa till huvudinnehåll Vi använder cookies och andra spårningsteknologier för att förbättra användarupplevelsen på vår webbplats, för att visa dig personligt innehåll och riktade annonser och för att analysera vår webbplatstrafik. Läs mer om cookies. Absolut nödvändiga cookies Dessa cookies är nödvändiga för att webbplatsen ska fungera och kan inte stängas a
https://www.lth.se/forskning/profilomraaden/vatten/ - 2026-07-16
Background: Cyclic Cushing's syndrome (cCS) features fluctuating cortisol secretion, often causing diagnostic errors or delays, and possibly poorer outcomes. We aimed to identify unpublished cCS cases to characterise clinical challenges and guide strategies for improving outcomes by characterising cycle patterns, peak frequency, and evaluating complications. Methods: This was a retrospective obser
Background: Childhood cancer survivors are at risk of subsequent primary soft-tissue sarcomas (STS), but the risks of specific STS histological subtypes are unknown. We quantified the risk of STS histological subtypes after specific types of childhood cancer.Methods: We pooled data from 13 European cohorts, yielding a cohort of 69 460 five-year survivors of childhood cancer. Standardized incidence
Precision nutrition is an emerging concept that aims to develop nutrition recommendations tailored to different people's circumstances and biological characteristics. Responses to dietary change and the resulting health outcomes from consuming different diets may vary significantly between people based on interactions between their genetic backgrounds, physiology, microbiome, underlying health sta
Fracture energy in birch Master’s Dissertation Structural Mechanics EMMA ESBJÖRNSSON and JOHAN SVENSSON EXPERIMENTAL TESTING OF BIRCH WOOD Fracture energy and its applicability in dowel-type joints DEPARTMENT OF CONSTRUCTION SCIENCES DIVISION OF STRUCTURAL MECHANICS ISRN LUTVDG/TVSM--24/5275--SE (1-78) | ISSN 0281-6679 MASTER’S DISSERTATION Supervisor: HENRIK DANIELSSON, Associate Professor, Divis
https://www.byggmek.lth.se/fileadmin/byggnadsmekanik/publications/tvsm5000/web5275.pdf - 2026-07-16
Department of Mechanical Engineering Division of Solid Mechanics ISRN LUTFD2/TFHF--04/5106--SE (1-83) ON THE INTERNAL ARCHITECTURE OF BONE BASED ON A CONTINUUM MODEL Master’s Dissertation by Zoltán Habony Supervisors Ingrid Svensson, Div. of Solid Mechanics Magnus Tägil, Dep. of Orthopaedics, Lund University Hospital Ian McCarthy, Biomechanics Laboratory, Dep. of Orthopaedics, Lund University Hosp
https://www.solid.lth.se/fileadmin/hallfasthetslara/utbildning/examensarbete/TFHF5106.pdf - 2026-07-16
Microsoft Word - Prosthesis_attachment_device_for_individuals_with_trans-radial_amputations_PRINT.docx Division of Solid Mechanics ISRN LUTFD2/TFHF--12/5166--SE (1-103) PROSTHESIS ATTACHMENT DEVICE FOR INDIVIDUALS WITH TRANS-‐RADIAL AMPUTATIONS Master’s Dissertation by Lukasz Szychlinski Supervisors Ingrid Svensson, Div. of Solid Mechanics
https://www.solid.lth.se/fileadmin/hallfasthetslara/utbildning/examensarbete/TFHF5166.pdf - 2026-07-16
BACKGROUND: Plasma biomarkers associated with Alzheimer's disease could improve prognostic assessment for people with Down syndrome in both clinical practice and research settings. We aimed to identify the plasma biomarkers that most accurately predict longitudinal changes in Alzheimer's disease-related pathology and cognitive functioning in individuals with Down syndrome.METHODS: This longitudina
Purpose: Humoral immunity proteins—immunoglobulins, complement proteins, and antimicrobial peptides—have key antimicrobial and immunomodulatory functions in sepsis. We hypothesised that their circulating levels are lower in non-survivors, potentially resulting in impaired bacterial clearance and persistent or recurrent infections. Methods: We performed a systematic review and meta-analysis evaluat
Rhesus macaques (RMs) are a vital model for studying human disease and are invaluable to preclinical vaccine research, particularly for the study of broadly neutralizing antibody responses. Such studies require robust genetic resources for antibody-encoding genes within the immunoglobulin (IG) loci. The complexity of the IG loci has historically made them challenging to characterize accurately. To
In pancreatic ductal adenocarcinoma (PDAC), the dense desmoplastic stroma and insufficient infiltrating T cells represent a significant barrier to effective immunotherapy. In this phase I, dose-escalation study, previously registered at the Dutch Trial Register and later on at ClinicalTrial (NCT05650918), we administer an autologous dendritic cell (DC) vaccine (MesoPher) with an agonistic CD40-spe
Background Oral contraceptives were introduced almost 50 years ago, and over 100 million women currently use them. Oral contraceptives can reduce the risk of ovarian cancer, but the eventual public-health effects of this reduction will depend on how long the protection lasts after use ceases. We aimed to assess these effects. Methods Individual data for 23 257 women with ovarian cancer (cases) a
Insufficient oxygen and nutrient supply often restrain solid tumor growth, and the hypoxia-inducible factors (HIF) 1 alpha and HIF-2 alpha are key transcription regulators of phenotypic adaptation to low oxygen levels. Moreover, mouse gene disruption studies have implicated HIF-2 alpha in embryonic regulation of tyrosine hydroxylase, a hallmark gene of the sympathetic nervous system. Neuroblastoma
BACKGROUND: Clinical outcome of patients with triple-negative breast cancer (TNBC) is highly variable. This study aims to identify and validate a prognostic protein signature for TNBC patients to reduce unnecessary adjuvant systemic therapy.METHODS: Frozen primary tumors were collected from 126 lymph node-negative and adjuvant therapy-naive TNBC patients. These samples were used for global proteom
BACKGROUND: Standard first-line antiretroviral therapy for HIV-1 infection includes two nucleoside or nucleotide reverse transcriptase inhibitors (NtRTIs), but these drugs have limitations. We assessed the 96 week efficacy and safety of an NtRTI-sparing regimen.METHODS: Between August, 2010, and September, 2011, we enrolled treatment-naive adults into this randomised, open-label, non-inferiority t
In the past years, extracellular vesicles (EVs) have become an important field of research since EVs have been found to play a central role in biological processes. In pathogens, EVs are involved in several events during the host–pathogen interaction, including invasion, immunomodulation, and pathology as well as parasite–parasite communication. In this report, we summarised the role of EVs in inf
Investigating the chemical homogeneity of stars born from the same molecular cloud at virtually the same time is very important for our understanding of the chemical enrichment of the interstellar medium and with it the chemical evolution of the Galaxy. One major cause of inhomogeneities in the abundances of open clusters is stellar evolution of the cluster members. In this work, we investigate va
The onset of inflammation is associated with reactive oxygen species and oxidative damage to macromolecules like 7,8-dihydro-8-oxoguanine (8-oxoG) in DNA. Because 8-oxoguanine DNA glycosylase 1 (OGG1) binds 8-oxoG and because Ogg1-deficient mice are resistant to acute and systemic inflammation, we hypothesized that OGG1 inhibition may represent a strategy for the prevention and treatment of inflam
BACKGROUND: Although rare in the general population, highly penetrant germline mutations in CDKN2A are responsible for 5-40% of melanoma cases reported in melanoma-prone families. We sought to determine whether MELPREDICT was generalizable to a global series of melanoma families and whether performance improvements can be achieved.METHODS: 2,116 familial melanoma cases were ascertained by the inte
