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Single-cell RNAseq is a routinely used method to explore heterogeneity within cell populations. Data from these experiments are often visualized using dimension reduction methods such as UMAP and tSNE, where each cell is projected in two or three dimensional space. Three-dimensional projections can be more informative for larger and complex datasets because they are less prone to merging and flatt
Injectable bioelectronics could become an alternative or a complement to traditional drug treatments. To this end, a new self-doped p-type conducting PEDOT-S copolymer (A5) was synthesized. This copolymer formed highly water-dispersed nanoparticles and aggregated into a mixed ion-electron conducting hydrogel when injected into a tissue model. First, we synthetically repeated most of the published
A high acoustic energy density is required in the acoustic resonator to increase the throughput of acoustophoresis devices. In this study, through both experiments and numerical simulations, we find that the energy density in bulk-wave-acoustophoresis devices can be enhanced by actuating the device from the side. Based on qualitative free-flow focusing experiments, side actuation shows clear super
Extracting information about emerging events in large study areas through spatiotemporal and textual analysis of geotagged tweets provides the possibility of monitoring the current state of a disaster. This study proposes dynamic spatio-temporal tweet mining as a method for dynamic event extraction from geotagged tweets in large study areas. It introduces the use of a modified version of ordering
BACKGROUND: Currently, only a limited number of molecular biomarkers for malignant melanoma exist. This is the case for both diagnosing the disease, staging, and efficiently measuring the response to therapy by tracing the progression of disease development and drug impact. There is a great need to identify novel landmarks of disease progression and alterations.METHODS: Matrix-assisted laser desor
The chemical composition of non-refractory submicron aerosol (NR-PM1) was characterized at the Villum Research Station (Villum) at Station Nord in North Greenland during spring-summer 2016 using a Time of Flight Aerosol Chemical Speciation Monitor (ToF-ACSM). The composition is dominated by sulfate (48%) and organic species (40%). Positive Matrix Factorization (PMF) identified three key factors co
Abstract to PLANNORD 2019: Future challenges for Nordic planning
Aims: The aim of this study was to evaluate the prevalence of triple antithrombotic therapy (TT) (warfarin, aspirin and clopidogrel) in patients following an acute coronary syndrome (ACS), the bleeding risk compared to double antiplatelet therapy (DAPT) (aspirin and clopidogrel) and evaluate the accuracy of the HAS-BLED risk score in predicting serious bleeding events in TT patients. Methods and r
Populärvetenskaplig sammanfattning: Under de senaste åren har det varit mycket fokus på biobränsle som ett sätt att reducera konsumtionen av fossila bränslen och utsläppet av växthusgaser. Flytande biobränslen kan blandas med bensin och diesel som ersättning för fossila bränslen i transportsektorn. Blandningar av biobränsle och bensin eller diesel kan användas direkt i omodifierade motorer och detUnder the Kyoto protocol the European Union (EU) has committed itself to reducing its greenhouse gas emissions to 92% of 1990 levels. Carbon sequestered in agriculture is allowed to be countered against emissions to help meet the targets. Biofuels represent an infinite possibility to sequester carbon in agriculture, as they reduce emissions by replacing fossil fuels. The EU has set the target that
Syfte: Syftet med denna studie är att undersöka vilka faktorer vid företagens börsintroduktioner, på NASDAQ OMX Stockholm och NGM Equity under åren 2001-2008, som påverkar sannolikheten att en efterföljande nyemission inträffar inom en kort tidsperiod (tre år). Metod: Studien är en kvantitativ undersökning där faktorer vid företagens IPO påverkar sannolikheten att en efterföljande SEO inträffar i
Den här uppsatsen syftar till att undersöka hur guldpriset påverkas av olika makroekonomiska variabler samt avkastningen på alternativa tillgångar. Studien är gjord ur ett amerikanskt perspektiv och undersöker hur priset på fysiskt guld påverkas av prisindexet Consumer Price Index – All Urban Consumers (CPI-U), BNP-tillväxt, aktieindexet MSCI US Prime Market 750 Index och Treasury bills med tre må
TRIM28 is a corepressor that mediates transcriptional silencing by establishing local heterochromatin. Here, we show that deletion of TRIM28 in neural progenitor cells (NPCs) results in high-level expression of two groups of endogenous retroviruses (ERVs): IAP1 and MMERVK10C. We find that NPCs use TRIM28-mediated histone modifications to dynamically regulate transcription and silencing of ERVs, wh
Digitalization has been frequently discussed within Competition Law over the last few years. It is not surprising that digital platforms have received a signif-icant amount of attention of among competition law experts and legislatures since a relatively few companies own the infrastructure needed for other com-panies to participate in the digital markets. The debate over the adequacy of our curre
Populärvetenskaplig sammanfattning Den ökande urbaniseringen värden över och de hälsorisker som identifierats i samband med värmeböljor i städer, har medfört att det urbana klimatet blivit ett allt viktigare forskningsområde. Vindhastighet är en av de viktigaste parametrarna när det gäller att beräkna lokala klimatvariationer och bedöma eventuella hälsorisker. En enkel beräkningsmetod för vind kanWind is a complex phenomenon and a critical factor in assessing climatic conditions and pedestrian comfort within cities. This master’s thesis attempts to quantify and model the relationship between near ground wind speed and urban geometry using two-dimensional raster data and variable selection methods based on Multiple Linear Regression. A simple regression model can be implemented in a Geogra
Developing efficient and robust computational models is essential to improve our understanding of protein solution behavior. This becomes particularly important to tackle the high-concentration regime. In this context, the main challenge is to put forward coarse-grained descriptions able to reduce the level of detail, while retaining key features and relevant information. In this work, we develop
Distinct transcriptomic profiles in children prior to the appearance of type 1 diabetes-linked islet autoantibodies and following enterovirus infection Article https://doi.org/10.1038/s41467-023-42763-9 Distinct transcriptomic profiles in children prior to the appearance of type 1 diabetes- linked islet autoantibodies and following enterovirus infection Jake Lin1,2,3,4,19, Elaheh Moradi1,5,19, Kar
https://www.teddy.lu.se/sites/teddy.lu.se/files/2024-02/159_MP183_Lin_NatureComm_2023.pdf - 2026-07-04
Access to detailed network data is often constrained by access-controlled datasets or by extensive manual labour. Using aerial imagery and a simplified OpenStreetMap road-level graph, a novel approach is proposed to extract lane-level road topology graphs at signalized intersections based on detection of common road objects, classification of lane attributes, and a simultaneous lane-to-lane connec
Monitoring insects of different species to understand the factors affecting their diversity and decline is a major challenge. Laser remote sensing and spectroscopy offer promising novel solutions to this. Coherent scattering from thin wing membranes also known as wing interference patterns (WIPs) have recently been demonstrated to be species specific. The colors of WIPs arise due to unique fringy
