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Complex diseases are caused by a combination of genetic, lifestyle, and environmental factors and comprise common noncommunicable diseases, including allergies, cardiovascular disease, and psychiatric and metabolic disorders. More than 25% of Europeans suffer from a complex disease, and together these diseases account for 70% of all deaths. The use of genomic, molecular, or imaging data to develop
Purpose: The majority of women with ovarian cancer are diagnosed in late stages. Most women do have symptoms prior to diagnosis, sometimes several months before the diagnosis. The aim of this study was to evaluate the timeline from the first presentation of symptoms to a physician until there is a reasonable suspicion of cancer, among women diagnosed with advanced stage ovarian cancer. We wanted t
Introduction: Health problems in people with intellectual and developmental disability (IDD) are traditionally known to be common in adults of all age, with at least twice as many health problems in this group as the general ageing population. In addition, there is considerable international evidence indicating an earlier death for people with IDD compared to the general population, exacerbated by
BACKGROUND: Epidemiological research on effects of transportation noise on incident hypertension is inconsistent.OBJECTIVES: We aimed to investigate whether residential road traffic noise increases the risk for hypertension.METHODS: In a population-based cohort of 57,053 individuals 50-64 years of age at enrollment, we identified 21,241 individuals who fulfilled our case definition of filling ≥2 p
Acute respiratory distress syndrome (ARDS) is a life-threatening condition with mortality rates between 30-50%. Although in vitro models replicate some aspects of ARDS, small and large animal models remain the primary research tools due to the multifactorial nature of the disease. When using these animal models, histology serves as the gold standard method to confirm lung injury and exclude other
Critical scholarship on the intersection of development pathways and climate change responses highlights the roles of power, agency, social difference, intersecting inequalities, and social justice in shaping people's resilience in a rapidly transforming world. Yet, how to precisely increase the spaces in which people experiencing marginalisation can address power asymmetries and strengthen their
The polar region is experiencing one of the most rapid environmental changes driven by atmospheric warming, and feedbacks within the cryosphere. Under such a setting, it is crucial to understand the biogeochemical cycling of the nutrient silicon (Si) in the high latitudes, which is regulating the nutrient supply to polar ecosystems, and is linked to the global carbon cycle via diatom production. H
The Ambient-Pressure X-ray Photoelectron Spectroscopy (APXPS) endstation at the SPECIES beamline at MAX IV Laboratory has been improved. The latest upgrades help in performing photo-assisted experiments under operando conditions in the mbar pressure range using gas and vapour mixtures whilst also reducing beam damage to the sample caused by X-ray irradiation. This article reports on endstation upg
Host-pathogen protein-protein interactions are highly complex and dynamic and mediate key steps in pathogen adhesion to host, host invasion, and colonization as well as immune evasion. In bacteria, these interactions most often involve specialized virulence factors or effector proteins that specifically target central host proteins. Here, I present a mass spectrometry-based proteomics approach sta
BACKGROUND: Precision medicine has the potential to improve cardiovascular disease (CVD) risk prediction in individuals with type 2 diabetes (T2D).METHODS: We conducted a systematic review and meta-analysis of longitudinal studies to identify potentially novel prognostic factors that could improve CVD risk prediction in T2D. Out of 9380 studies identified, 416 studies met inclusion criteria. Outco
Modern microbial and ecosystem sciences require diverse interdisciplinary teams that are often challenged in “speaking” to one another due to different languages and data product types. Here we introduce the IsoGenie Database (IsoGenieDB; https://isogenie-db.asc.Ohio-state.edu/), a de novo developed data management and exploration platform, as a solution to this challenge of accurately representin
State-structured populations are ubiquitous in biology, from the age-structure of animal societies to the life cycles of parasitic species. Understanding how this structure contributes to eco-evolutionary dynamics is critical not only for fundamental understanding but also for conservation and treatment purposes. Although some methods have been developed in the literature for modelling eco-evoluti
Chronic lymphocytic leukemia (CLL) is the most common leukemia among adults worldwide. Although genome-wide association studies (GWAS) have uncovered the germline genetic component underlying CLL susceptibility, the potential use of GWAS-identified risk variants to predict disease progression and patient survival remains unexplored. Here, we evaluated whether 41 GWAS-identified risk variants for C
Mycoplasma bovis (M. bovis) infections are difficult to diagnose and treat, causing severe economic losses to farms with infected cows. Eurofins Milk Testing Sweden AB screens cow’s milk using qPCR (quantitative Polymerase Chain Reaction) to detect M. bovis infections. Five performance characteristics were chosen to evaluate if ELISA (Enzyme-Linked Immunosorbent Assay) could replace the current sc
Simulations of large detectors such as the ATLAS detector at the LHC (Large Hadron Collider) are compute-intensive projects, and are according to current internal estimates expected to be consuming 40 % of the total ATLAS CPU resources in 2020, creating a need for software optimization strategies. We investigate build configurations of the Geant4 simulation software to find if a) a performance imp
Methylation of lysine (Kme) is known to regulate several important functions, altering gene expression and cell cycle progression. However, mass spectrometry based proteomic analysis of the modification has not been possible due to the lack of efficient purification strategies to enrich modified peptides for analysis. In this study, we identified and evaluated several in-house and commercial candi
The demand for high data rates in a wireless communication system has experienced a remarkable growth over the last years. This demand is continually increasing with the growing number of wirelessly connected devices. Thus, there is a continuing hunt for increasing the data transmission rate in wireless communication systems. To increase the data rate, the modern wireless communication system cann
Though the diffusion of electric vehicle (EV) is high on the global agenda, and there are efforts to speed up the shift: some countries intend to ban the sale of internal combustion engine vehicles (ICEV), and some OEMs (original equipment manufacturers) have announced the goal of electrification, the diffusion of EV is slowly. Technological innovation theory explains that we need to harmonise tec
This thesis is a conceptual study focused on the relationship between populism and conspiracy theories to see if populism poses a totalitarian threat to democracy. Starting with a discussion on democracy and populism, this thesis examines the relations between conspiracy theories and populism as well as their respective constructions. Thereafter, departing from Hannah Arendt’s book the Origins of
