Filetype
Pedagogical development programmes (PDPs) are important for developing teaching skills for university teaching staff. Due to participants’ different teaching roles, their professional development needs and interests may also be different. However, little is known regarding the immediate needs of university teaching staff when they enter PDPs and how these may differ according to their roles. This
The local average treatment effect (LATE) estimator has enabled a wide range of empirical studies that usenatural experiments to estimate causal effects from observational data. However, this empirical literature has overlooked a crucial assumption regarding the definition of the treatment—thepart of the stable unit treatment value assumption referred to asthe consistency assumption in epidemiolog
The emergence of antibiotic resistance necessitates effective strategies for evaluating antimicrobial agents. Bioluminescent bacteria, either naturally occurring or engineered with modified reporter genes like bacterial luciferase, provide real-time assessment of bacterial viability through light emission. We investigated the antibacterial effects of cefotaxime and doxycycline using bioluminescent
Hydrogen-fuelled technologies for home heating and cooking may provide a low-carbon solution for decarbonising parts of the global housing stock. For the transition to transpire, the attitudes and perceptions of consumers must be factored into policy making efforts. However, empirical studies are yet to explore potential levels of consumer heterogeneity regarding domestic hydrogen acceptance. In r
InP quantum dots have emerged as a promising ecofriendly alternative to cadmium-based QDs for next-generation display applications. However, red-emitting InP QDs synthesized via aminophosphine precursors still suffer from broad emission spectra and limited stability. In this study, we present a strain-engineered InP/ZnSe/ZnSexS1-x/ZnS QD structure featuring a gradient alloyed ZnSexS1-x shell that
OBJECTIVES: This is a protocol for a Cochrane Review (prototype). The objectives are as follows: Primary objective To determine the prognostic value of birth weight (BW) and prematurity in predicting the incidence of type 2 diabetes mellitus (T2DM) later in life (among adults, adolescents, and children) compared to normal BW and full-term birth. Secondary objectives To determine the prognostic val
Purpose: To assess the ability of corneal epithelial aberrations to discriminate forme fruste keratoconus (FFKC) and keratoconus (KC) from normal eyes. Methods: This prospective, case-control study enrolled 91 right eyes from 91 normal participants, 87 eyes with FFKC and 148 eyes with KC. Epithelial aberrations for the 6-mm pupil were measured using an anterior segment optical coherence tomography
Proteins and peptides are vital biomolecules, and deuterated amino acids are increasingly applied in areas such as drug discovery, metabolic tracing, and neutron scattering studies. In this study, we performed deuteration on all 20 proteinogenic amino acids, including their side chains, and established efficient methods for 13 amino acids. Using a Pt/C-catalyzed hydrogen–deuterium exchange reactio
The retinoblastoma gene (RB1), which is located on chromosome 13q14.2, is mutated in retinoblastoma (RB), the most common malignant intraocular tumor in children. About 8000 new cases of retinoblastoma are diagnosed globally each year, accounting for approximately 1 in 17,000 live births. RB is prototypically considered hereditary by nature as thirty to forty percent of cases have autosomal domina
The Cherenkov Telescope Array (CTA) is the future observatory for ground-based imaging atmospheric Cherenkov telescopes. Each telescope will provide a snapshot of gamma-ray induced particle showers by capturing the induced Cherenkov emission at ground level. The simulation of such events provides camera images that can be used as training data for convolutional neural networks (CNNs) to differenti
Dopaminergic neurons in the ventral midbrain are critical for regulating movement, cognition, and emotion. Ventral midbrain organoids can be used to model both development and diseases of the dopaminergic system, especially Parkinson’s disease. Here, we summarize recent advances and remaining challenges in developing such three-dimensional organoids from human pluripotent stem cells. We outline ho
This study investigates the neural encoding of speech features in hearing aid users using electroencephalography (EEG) during a simulated cocktail party scenario. The objective was to investigate neural tracking of various acoustic and linguistic features and how hearing aid noise reduction influenced this tracking. The features analyzed included the acoustic envelope, phonetic features, word onse
Neuroblastoma (NB) is a heterogeneous childhood cancer, characterized by the amplification of the MYCN oncogene in 40% of the high-risk cases. Our previous work demonstrated that MYCN drives metabolic reprogramming in NB, including upregulation of antioxidant enzymes. Here, we identify peroxiredoxin 6 (PRDX6) as a promising therapeutic target in NB. Pharmacological inhibition of PRDX6 reduces MYCN
Motivation Efforts to address health disparities are often limited by the lack of robust computational tools for inferring genetic ancestry by calculating an individual's genetic similarity to continental groups. We have already shown that a preferred alternative to self-described race is using ancestry-informative markers (AIMs) that can be classified into ancestral components and used to estimat
Purpose: Developmental language disorder (DLD) has known consequences on academic performance, and adaptations to teaching methods and material are often required to counteract negative outcomes. This study used first-hand reports from students with DLD and their caregivers to explore how individual and school-related factors influence academic achievement and provision of educational support. Met
Soma design is intimately entangled with the politics, not only of design itself, but of bodies. We combine perspectives from soma design, political theory, and Sara Ahmed’s work The Cultural Politics of Emotions, to develop five political provocations that reflect on the politics of soma design and the possibilities and frictions therein. Inspired by soma design’s roots in somaesthetic philosophy
The Polarization and Impedance Controlled Car (PICC) presents an innovative approach for demonstrating and teaching key principles of electromagnetic field theory, specifically polarization and impedance. Designed as an interactive learning tool, the PICC utilizes a radio-controlled car, NanoVNA, Raspberry Pi, and handheld antennas to visualize real-time effects of polarization and impedance. The
Epitaxially grown nanowires have shown promise for photovoltaic applications due to their nanophotonic properties. Moreover, the mechanical properties of nanowires can reduce crystallographic defect formation at interfaces to help enable new material combinations for photovoltaics. One material that stands to benefit from the nanowire morphology is zinc phosphide (Zn3P2), which, despite promising
Aims To study the prevalence of masked uncontrolled hypertension (MUCH) in patients recently hospitalized for myocardial infarction, and to develop machine learning-based prediction models identifying MUCH. Methods and results Ambulatory blood pressure measurement (ABPM) was performed in 99 patients following hospitalization for a myocardial infarction. Sixty-two clinical variables were eligible f
Memory decline is a central cognitive symptom in Parkinson’s Disease (PD). While task-fMRI studies link hippocampal activity (AHA) to poorer memory and olfactory performance, this relationship during rest remains understudied. The objectives of this study are to examine differences in resting-state hippocampal networks, explore the occurrence of reduced AHA within these networks, and investigate i
