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Stem cell lines that faithfully maintain the regional identity and developmental potency of progenitors in the human brain would create new opportunities in developmental neurobiology and provide a resource for generating specialized human neurons. However, to date, neural progenitor cultures derived from the human brain have either been short-lived or exhibit restricted, predominantly glial, diff

Metal-assisted chemical etching (MACE) is a cheap and scalable method that is commonly used to obtain silicon nano- or microwires but lacks spatial control. Herein, we present a synthesis method for producing vertical and highly periodic silicon microwires, using displacement Talbot lithography before wet etching with MACE. The functionalized periodic silicon microwires show 65% higher PEC perform

Objectives: To evaluate a cancer detecting artificial intelligence (AI) algorithm on serial biopsies in patients with prostate cancer on active surveillance (AS). Patients and methods: A total of 180 patients in the Prostate Cancer Research International Active Surveillance (PRIAS) cohort were prospectively monitored using pre-defined criteria. Diagnostic and re-biopsy slides from 2011 to 2020 (n

• We aimed to capture possible insights from an AI diagnosing without human guidance.• We believe the result mainly aligns with previous knowledge. Though, vital signs and sex did not aid the AI diagnostics.

The recently developed Phase-Scaled Reassignment (PSR) can estimate phase-difference between two oscillating transient signals with high accuracy. However, in low signal-to-noise ratios (SNRs) the performance of commonly applied reassignment techniques is known to deteriorate. In order to reduce variance in low SNR, we propose a multitaper PSR (mtPSR) method for phase-difference estimation between

Coherence is a useful measure in many engineering applications. Here, we focus on the case where the input signal to a linear system can be measured free from noise, but the output signal is perturbed by noise. A novel expression for the expectation of a multitaper magnitude squared coherence estimate for this case is presented and verified through numerical evaluation. Additionally, the expressio

Introduction: Diabetic peripheral neuropathy (DPN) is a common complication of both type 1 (T1D) and type 2 diabetes (T2D). No cure for DPN is available, but several potential targets have been proposed for treatment. Heat shock proteins (HSPs) are known to respond to both hyper- and hypoglycemia. DPN can be diagnosed using electrophysiology and studied using peripheral nerve biopsies.Aim: This st

Nanoplastics have been proven to induce toxicity in diverse organisms, yet their effect on soil microbes like bacteria and fungi remains largely unexplored. In this paper, we used micro-engineered soil models to investigate the effect of polystyrene (PS) nanospheres on Pseudomonas putida and Coprinopsis cinerea. Specifically, we explored the effects of increasing concentrations of 60 nm carboxylat

The great variety of earth's microorganisms and their functions are attributed to the heterogeneity of their habitats, but our understanding of the impact of this heterogeneity on microbes is limited at the microscale. In this study, we tested how a gradient of spatial habitat complexity in the form of fractal mazes influenced the growth, substrate degradation, and interactions of the bacterial st

Background:In early breast cancer, five histopathological biomarkers are part of current clinical routines and used for determining prognosis and treatment: estrogen receptor (ER), progesterone receptor (PgR), human epidermal growth factor receptor 2 (ERBB2/HER2), Ki67, and Nottingham histological grade (NHG). We aimed to develop classifiers for these biomarkers based on tumor mRNA-sequencing (RNA

Variation of the blood content of the pulmonary vascular bed during a heartbeat can be quantified by pulmonary blood volume variation (PBVV) using magnetic resonance imaging (MRI). The aim was to evaluate if PBVV differs in patients with heart failure compared to healthy controls and investigate the mechanisms behind the PBVV. Forty-six patients and 10 controls underwent MRI. PBVV was calculated f

The following thesis examines the work of the early swedish transplant surgeons with special regards to the question of organ procurement. Through a careful reading of letters during 1971-1986, left from one prominent swedish transplant surgeons of that time – Sven-Eric Bergentz – I investigate how clinicians sought ways to solve the controversial problem of organ procurement. The institutionaliza

Lipid nanoparticles (LNPs) are clinically approved for mRNA-based vaccines and liver-targeted siRNA delivery. However, poor nucleic acid delivery efficiency limits their application in extrahepatic tissues and tumors. Here, using live-cell and super-resolution microscopy, we identify multiple distinct steps of inefficiencies in the cytosolic delivery of both siRNA and mRNA cargoes. Membrane damage

ObjectivesFrequent blood sampling in vulnerable patient groups, such as prematurely born infants, can lead to significant blood loss and increased transfusion needs. Current pre-analytical technology requires comparably large blood volumes and leads to discarding of cells. This study investigates a device prototype enabling in-line sampling where cell-reduced plasma for clinical chemistry analyses

PURPOSE: To assess whether higher plasma 25-hydroxyvitamin D [25(OH)D] is associated with improved outcomes in colon cancer and whether circulating inflammatory cytokines mediate such association.EXPERIMENTAL DESIGN: Plasma samples were collected from 1,437 patients with stage III colon cancer enrolled in a phase III randomized clinical trial (CALGB/SWOG 80702) from 2010 to 2015, who were followed

Objective: To examine the performance of ultrasound (US) for the diagnosis of gout using the presence of monosodium urate monohydrate (MSU) crystals as the gold standard. Methods: We analyzed data from the Study for Updated Gout Classification Criteria (SUGAR), a large, multicenter observational cross-sectional study of consecutive subjects with at least 1 swollen joint who conceivably may have go

Hälsovetenskapens dag arrangeras årligen av Institutionen för hälsovetenskaper vid Medicinska fakulteten. I år presenteras aktuell forskning på temat ”Implementering av nya arbetssätt i vård och samhälle”. Ta del av ett intressant och innehållsrikt program med föreläsningar, science slam och möjligheten att ställa frågor till våra forskare. För vem Yrkesverksamma inom hälso- och sjukvården, forska

https://www.medicin.lu.se/sites/medicin.lu.se/files/program_-_halsovetenskapens_dag_1.pdf - 2026-06-20

Karin Hofuendahl Från: Skickat: Tiil: Kopia: Ämne: Karin Hofuendahl den 10juni 2019 17:12 Caroline lsaksson; Erik Swietlicki; Helena Filipsson; Henrik Smith; Johannes Stripple; Kimberly Nicholas; Linda Lundmark; Maj-Lena Linderson; Maria Äkesson; Paul Miller; Sofi Elmroth; Timothy Willams (ti7B71wi-s@student.lu.se); Torbjörn Brorson; Yvonne Persson William Sidemo Holm; Karin Hofuendahl;Tom Briliot

https://www.cec.lu.se/sv/sites/cec.lu.se.sv/files/2021-09/Protokoll%202019-06-10%20(PDF,%202KB,%20ny%20flik).pdf - 2026-06-20

Workshop om mätfelsbehandling NRCF 2025 1 Mätfelsbehandling Antalet gällande siffror En mätning som anges som 12 cm eller 1,2 dm eller 0,12 m eller 0,00012 km anges med lika många, dvs. två, gällande siffror (värdesiffror, signifikanta siffror). Detta innebär att alla uttrycken har samma noggrannhet. Nollor i början är inte gällande, de beror bara på valet av enhet. Nollor i mitten är gällande och

https://www.nrcf.lu.se/sites/nrcf.lu.se/files/2025-03/Workshop%20material%20final%2020250311.pdf - 2026-06-20