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PURPOSE: Major hurdles in oXHTx are the delayed xenograft rejection, the early perioperative cardiac xenograft dysfunction (PCXD) and the pig heart overgrowth, which were solved in this study with a costimulation blockade, a new non-ischemic cold preservation and a growth inhibition by anti-proliferative drugs. Aim was to achieve a 90-days-survival of minimal 60% (6 of 10 baboons) in this life-sup

Energy dispersive x-ray spectroscopy in a transmission electron microscope is often the first method employed to characterize the composition of nanowires. Ideally, it should be accurate and sensitive down to fractions of an atomic percent, and quantification results are often reported as such. However, one can often get substantial errors in accuracy even though the precision is high: for nanowir

Background/Purpose: The need for transitional care has gained increased focus in the treatment of patients with congenital colorectal disorders. We aimed to acquire in-depth knowledge about the experiences of adult patients with Hirschsprung's disease (HD) and their suggestions for transitional care. Methods: Binational study applying gender equal focus group interviews (FGI). Results: Seventeen (

A novel strategy is presented for reliable diagnosis and progression prediction of diseases with special attention to COVID-19 pandemic. A plan is presented for how the model can be implemented worldwide in healthcare and how novel treatments and targets can be detected. The idea is based on poikilosis, pervasive heterogeneity, and variation at all levels, systems, and mechanisms. Poikilosis in di

In this paper we present a method for simultaneously segmenting brain tumors and an extensive set of organs-at-risk for radiation therapy planning of glioblastomas. The method combines a contrast-adaptive generative model for whole-brain segmentation with a new spatial regularization model of tumor shape using convolutional restricted Boltzmann machines. We demonstrate experimentally that the meth

The validation of an evacuation model is generally performed through testing its predictive capabilities within a set of standard environments (e.g. buildings) or standard layouts. Unfortunately, non-expert users could consider model results as reliable in unique environments as well, such as road tunnels, and extend their use to applications where no ad hoc validation tests have been performed. T

A detailed study has been made of the method for labeling streptokinase with 99Tc(m) in order to get a radioactive indicator for rapid scintigraphic visualization of thrombi and emboli. The best method found for preparing 99Tc(m) streptokinase was by reducing 99Tc(m) pertechnetate with 2 μmole SnCl2 at pH 0.7 and then adding 50,000 to 75,000 IU of streptokinase at a final pH of about 2. After 1 hr

We analyse the performance of risk reduction strategies for terrorist attacks with Improvised Explosive Devices (IEDs) for large governmental building structures in terms of cost-efficiency, significance and effectiveness accounting for life safety in conjunction with societal preferences and capabilities. The approach builds upon an extended Bayesian pre-posterior decision analysis and the princi

This article introduces an approach and framework for the quantification of the value of structural health monitoring (SHM) in the context of the structural risk and integrity management for systems. The quantification of the value of SHM builds upon the Bayesian decision and utility theory, which facilitates the assessment of the value of information associated with SHM. The principal approach fo

Photonic materials for high-temperature applications need to withstand temperatures usually higher than 1000 °C, whilst keeping their function. When exposed to high temperatures, such nanostructured materials are prone to detrimental morphological changes, however the structure evolution pathway of photonic materials and its correlation with the loss of material's function is not yet fully underst

Adult neurogenesis in the mammalian brain, including in humans, occurs throughout life in distinct brain regions. Alterations in adult neurogenesis is a common phenomenon in several different neurodegenerative disorders, which is likely to contribute to the pathophysiology of these disorders. This review summarizes novel concepts related to the interplay between autophagy and microRNAs in control

We study planning problems where the transition function is described by a learned binarized neural network (BNN). Theoretically, we show that feasible planning with a learned BNN model is NP-complete, and present two new constraint programming models of this task as a mathematical optimization problem. Experimentally, we run solvers for constraint programming, weighted partial maximum satisfiabil

Policy for science, technology, and innovation is increasingly supporting bottom-up approaches to setting strategic agendas for research and innovation (R&I). These processes are designed to bring industrial needs of R&I intensive sectors to the fore, while at the same time stimulating engagement of other relevant stakeholders, such as public and private research performers. This paper add

We report on the status of efforts to improve the reinterpretation of searches and measurements at the LHC in terms of models for new physics, in the context of the LHC Reinterpretation Forum. We detail current experimental offerings in direct searches for new particles, measurements, technical implementations and Open Data, and provide a set of recommendations for further improving the presentati

As treatment evolves and the population who survive childhood cancer ages and increases in number, researchers must use novel approaches to prevent, identify and mitigate adverse effects of treatment. Future priorities include collaborative efforts to pool large cohort data to improve detection of late effects, identify late effects of novel therapies, and determine the contribution of genetic fac

We study the propagation and diffusion of electric charge fluctuations in the Bjorken hydrodynamic model with both white and Catteneo noise using purely numerical methods. We show that a lattice of noise fluctuations is required to fully calculate the two-point correlators of charge. We introduce a numerical procedure to solve the stochastic differential equations that arise from the charge conser

Prior to the COVID-19 crisis, global air transport demand was expected to triple between 2020 and 2050. The pandemic, which reduced global air travel significantly, provides an opportunity to discuss the scale, distribution and growth of aviation until 2018, also with a view to consider the climate change implications of a return to volume growth. Industry statistics, data provided by supranationa