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Thymidine kinase 1 from tomato (ToTK1) is a newly discovered deoxyribonucleoside kinase (dNK) that has been subject to study due to its in vitro and in vivo properties making it an interesting suicide gene candidate for the treatment of brain tumors. The ToTK1 phosphorylates the nucleoside analogue 3-azido-2,3-dideoxythymidine (azidothymidine, AZT) equally well as its natural substrate thymidine (

In the present study, the enzyme thymidine kinase 1 from tomato (ToTK1) was expressed in E.coli and purified to near homogeneity by means of affinity chromatography. However, purified ToTK1 of bacterial origin displayed no substantial catalytic activity. Expression was also attempted in insect cells using the baculovirus expression vector system (BEVS). Significant TK activities were detected in t

The relationship between business cycles and mortality has been a highly debated subject in the field of economics. The majority of previous studies, using the unemployment rate as the main proxy for macroeconomic conditions, have found ambiguous effects largely depending on how the effect is estimated. This thesis follows the methodology used by Ruhm (2000), but instead applies aggregate data for

This thesis covers specification and development of a distributed measurement system intended for CAN bus. It was completed at Scania CV, Södertälje in collaboration with Lund University. The goal of the thesis is to specifiy and develop a distributed measurement system that helps Scania with acquisition of functional and electrical data. Several topics are adressed such as filtering, at what spee

Designing and developing a software product is a difficult process. The product must be usable and solve the correct problem. At the same time, the underlying code must be well written. Many projects fail to deliver or exceed their budget. This thesis explores a practical approach to software design and development that tries to adhere to both user centered design and agile development. The proces

In gas turbine blade modeling a stable but yet flexible method of describing the blade shape is crucial. Polynomials and B ́ezier curves have previously been used and in this paper B-splines are employed instead. This method removes the need for many of the interior derivative conditions on the curve but special care must be taken when selecting the parameter values and appropriate derivative cond

The wide and increasing range of screen sizes between Android devices makes consumers use them very differently. Large devices (like televisions) are more suitable to view content and smaller devices (like smart watches) are to be used more as a quick controller of the main application. Distributed user interfaces is the concept of utilizing several of these de- vices in one application, so that e

The main goal of this project was to use the Modelica features on embedded systems, real-time systems and basic mechanical modeling for the control of a two-wheeled self-balancing personal vehicle. The Elektor Wheelie, a Segway-like vehicle, was selected as the process to control. Modelica is an object-oriented language aimed at modeling of complex systems. The work in the thesis used the Modelica

ARTICLE The 6 year incidence of diabetes-associated autoantibodies in genetically at-risk children: the TEDDY study Jeffrey P. Krischer & Kristian F. Lynch & Desmond A. Schatz & Jorma Ilonen & Åke Lernmark & William A. Hagopian & Marian J. Rewers & Jin-Xiong She & Olli G. Simell & Jorma Toppari & Anette-G. Ziegler & Beena Akolkar & Ezio Bonifacio & the TEDDY Study Group Received: 4 September 2014

https://www.teddy.lu.se/sites/teddy.lu.se/files/06032016_679_43_krischer_diabetologia_2015.pdf - 2026-07-23

This master’s thesis examines similarities and differences in operational work, training, and the use of technology related to Smart Firefighting in Sweden and Hong Kong. Smart Firefighting has been proposed as a response to challenges arising from modern urban development, where data from smart buildings, combined with AI and digital tools, could support fire and rescue services. However, such da

This thesis focuses on how online activists react to online censorship imposed onto them by social media platforms and how the reactions shape the activists’ responses to the censorship. It does so by deploying a qualitative interview study design onto how Swedish individuals who advocate for Palestine online experience and respond to digital censorship on Meta’s social media platforms. In the st

Climate change poses serious questions about how social work can address environmental issues. This study departs from an ecosocial approach and aims to explore how social workers in Sweden conceptualize and respond to climate change in social work practice. This study employed a thematic analysis where the collected data consisted of qualitative semi-structured interviews with four social work pr

The rapid evolution of machine learning techniques has revolutionized computer vision, particularly with the introduction of Neural Radiance Fields (NeRF) and the optimization of 3D Gaussians for rendering novel scene views. These methods, such as NeRF and Gaussian Splatting, have demonstrated success in synthetic data scenarios with consistent lighting and well-captured scenes. This research expl

Global population growth presents challenges to sustainable food and energy produc- tion. Transitioning to renewable energy sources, like solar power, requires significant land allocations, conflicting with the need for arable farmland. Agrivoltaics (AV) offers a potential solution by integrating crops and solar panels on the same land. Ensuring consistent and adequate agricultural output alongsid

This thesis explores the feasibility of integrating a fall detection system into microprocessor-controlled prosthetic knees using onboard sensors, with a focus on optimizing machine learning models for real-time operational efficiency within the limited computational capacities of such devices. Initial investigations utilized the public UMAFall dataset to gain insights into fall detection methodol

This master thesis explores the neural encoding of speech features for hearing aid users. The study utilizes electroencephalography (EEG) and audio data from an experiment that stimulates a Cocktail Party scenario. This is a complex auditory scene, especially difficult for individuals with hearing impairments. The primary objective of the study is to investigate how different acoustic and linguist

This thesis seeks to answer the question of whether obligations to primary pandemic prevention and bio-risk management can be derived from the human right to health. The definition of the right to health in Article 12 of the International Covenant on Economic, Social, and Cultural Rights (ICESCR) was selected, as it is the broadest definition of the right to health in international human rights la

Ovarian cancer remains a significant challenge in oncology, with current treatments having a high recurrence rate making further investigations into treatment targets and the heterogeneity of cancers necessary. As findings from cell lines models are hard to transfer to in vivo cancers, we wanted to explore possibilities to better integrate cell line and tissue omics data. To do so, this study leve

This thesis aims to compare the user experience of an alarm system, which in- cludes a conventional alarm list, with newly developed graphical ways to display alarms. In addition to these visual enhancements, new features requested by users, such as the ability to park alarms to minimise the overwhelming feelings during an alarm flood were integrated. Three iterations with usability tests were con