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Mutational signatures are patterns of mutations that arise during tumorigenesis. We present an enhanced, practical framework for mutational signature analyses. Applying these methods to 3,107 whole-genome-sequenced (WGS) primary cancers of 21 organs reveals known signatures and nine previously undescribed rearrangement signatures. We highlight interorgan variability of signatures and present a way
The present study explored presence of meaning in life, search for meaning in life, and their correlation with health anxiety. The Meaning in Life Questionnaire and the Short Health Anxiety Inventory were completed by 753 individuals. Results indicated higher presence of meaning in life was associated with lower health anxiety, while the opposite was observed for search for meaning in life. Result
Innovation auditing is a well-established practice used by managers to identify strengths and weaknesses in innovation. Existing audit frameworks fall short, however, because they neglect three major trends that currently transform the innovation landscape. These trends are as follows: 1) a shift from closed to more open models of innovation (“openness”), 2) a shift from providing physical product
Doses to the eyes of interventional radiologists and cardiologists could exceed the annual limit of 20 mSv proposed by the International Commission on Radiological Protection. Lead glasses of various designs are available to provide protection, but standard eye dosemeters will not take account of the protection they provide. The aim of this study has been to derive dose reduction factors (DRFs) eq
Massive MIMO is a compelling wireless access concept that relies on the use of an excess number of base-station antennas, relative to the number of active terminals. This technology is a main component of 5G New Radio and addresses all important requirements of future wireless standards: a great capacity increase, the support of many simultaneous users, and improvement in energy efficiency. Massiv
Glass is largely used in architectural and engineering applications (i.e., buildings and vehicles) as a structural material, especially in the form of laminated glass (LG) sections. To achieve adequate and controlled safety levels in these applications, the well-known temperature-dependent behavior of viscoelastic interlayers for LG sections should be properly accounted for during the design proce
A search for the exclusive decays of the Higgs and Z bosons to a ϕ or ρ meson and a photon is performed with a pp collision data sample corresponding to an integrated luminosity of up to 35.6 fb−1 collected at s=13 TeV with the ATLAS detector at the CERN Large Hadron Collider. These decays have been suggested as a probe of the Higgs boson couplings to light quarks. No significant excess of events
During the recent years improved operation techniques and administrative procedures have been developed for early rehabilitation. At the same time preoperative lifestyle intervention (prehabilitation) has revealed a large potential for additional risk reduction. The aim was to assess the quality of life and to estimate the cost-effectiveness of standard care versus an integrated programme includin
Dagens samhälle präglas av globalisering och gränsöverskridande handel. I vår del av världen verkar EU och den fria rörligheten som inte bara ger människor och företag rättigheter utan även påverkar våra skatter. I centrum för handeln återfinns företagen, stora som små, som vågar ta klivet över till andra marknader för att se om de klarar av konkurrensen och på sikt öka vinsten då nya marknader inToday’s society is globalised with international trade as a consequence. In our part of the world the EU with it’s advantages and disadvantages concerning the free movement of capital, people and business affects us all, but also our taxes. Companies, big and small are in the centre of the cross-border trade with their expansion into new markets. Business adventures of this kind can generate incre
Integrated Assessment and Modelling (IAM) provides an interdisciplinary approach to support ex-ante decision-making by combining quantitative models representing different systems and scales into a framework for integrated assessment. Scenarios in IAM are developed in the interaction between scientists and stakeholders to explore possible pathways of future development. As IAM typically combines m
With the rapid development of blood biomarkers (BBMs) related to amyloid-β (Aβ) pathology in Alzheimer's disease (AD), the question arises whether these can replace the accepted reference standard, positron emission tomography (PET), for assessing Aβ burden. BBMs can differentiate Aβ status reliably in cognitively impaired patients, but two-threshold strategies to further improve their performance
This thesis examines the market access barriers faced by small-scale producers in Bolivia, with a focus on Chiquitania, Los Valles Cruceños, and Zongo. Drawing on 15 semi-structured interviews with producers, vendors, university staff, and institutional actors, it analyses how structural, institutional, and relational barriers shape not only producers’ ability to reach markets, but also their abil
Popular Abstract in Swedish Kolhydrater är viktiga inte bara som bränsle och strukturgivande egenskaper, vilket var uppfattningen för 25 år sedan. De ingår även som en mycket viktig del i hur celler kommunicerar med varandra. Det har de senaste åren visat sig vara kolhydrater inblandade i en mängd signalering- och igenkänningsmekanismer. Några exempel: när bakterier angriper en cell är det oftast Artificial, amfiphilic, and biomimetic receptors soluble in water were synthesized via attaching polar amino acids to hydrophobic back-bones possessing a surface suitable for hydrophobic interactions. The hydrophobic back-bones chosen in this thesis were anthracene and dibenzobarrelene structures. A route to an efficient synthesis of a dibenzobarrelene backbone with two sets of orthogonal reactivi
Borderline Personality Disorder (BPD) has largely been associated with self-harm and chronic suicidality, despite the fact that these behaviours comprise only one diagnostic criterion. Treatments for self-harm are mostly indicated for individuals with BPD. Emerging literature suggests that youth with histories of depression are at risk of both self-harm and completed suicide. For individuals with
Aim: Attention-deficit/hyperactivity disorder (ADHD) is the most common diagnosis within child- and adolescent psychiatry. Waiting lists and delayed care are major issues. The aim was to evaluate if standardized care (SC) for assessment and treatment of uncomplicated ADHD would reduce resource utilization and increase satisfaction with preserved improvement within the first year of treatment. Meth
To validate and evaluate the psychometric properties of the ALPS-Neo, a new pain assessment scale created for the continuous evaluation of pain and stress in preterm and sick term infants.
